Predictive Value of Circulating Vascular Endothelial Growth Factor-1 in Arterial Hypertension Patients

Berezin, Alexander E.; Oa, Lisovaya

doi:10.4172/2165-8048.s11-006

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…Overall, VEGF-1 acts as trophic factor with angiopoetic and neuroprotective properties [10,12]. Elevated level of VEGF-1 was recently found in patients after acute stroke and they were demonstrated predictive value for recurrent CV events in long-term follow up [13,14]. Although a neurologic deficit of sudden onset conforming to a vascular territory is a clear clinical indication in acute ischemic stroke, the predictive role of VEFG-1 for neurologic recovery in short-term period is still not clear.…”

Section: Introductionmentioning

confidence: 96%

Vascular Endothelial Growth Factor-1 Level and Functional Neurologic Recovery after Ischemic Hemispheric Stroke

Medvedkova¹,

Berezin²

2015

Neurochem Neuropharm

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Background: Vascular endothelial growth factor-1 (VEGF-1) acts as endogeneous angiopoetic and neuroprotective factor. The aim of the study to investigate an interrelationship between VEFG-1 elevation and neurologic recovery in short-term period among patients with ischemic hemispheric stroke.Methods: Seventy eight patients with ischemic hemispheric stroke were included in the study. Neurological impairment at presentation was assessed according National Institute of Health Stroke Scale. The Barthel Index and the modified Rankin Scale (mRS) were used to assess functional disability. Concentrations of VEGF-1 were measured at baseline using ELISA laboratory kit. Results:The total prevalence of hypertension was 100% (78 patients). 79.5% patients had dyslipidemia, 18% were diabetic, 15.4% of the total population was smokers. Among study patient population a total of 19.2% subjects had a past history of ischemic heart diseases in their families and 11.5% had experienced a previous ischemic heart episode. Within 6 month after baseline the favorable neurologic recovery defined as mRS ≤ 2 was found in 64 patients (82.1%). We calculated Modified Rankin Score ≥ 3 in 14 patients (17.9%). Depending on Modified Rankin Score at 6 month (≤ 2 and ≥ 3) we have divided all patients into two sub-groups respectively. We found a higher prevalence of subjects with dyslipidemia (P=0.044), diabetes mellitus (P=0.024), smokers (P=0.025) and as well as those with ischemic heart disease in their family histories (P=0.026) and previous ischemic heart episode (P=0.032) in subgroup with mRS ≥ 3. At baseline VEGF-1 concentration in entire patient cohort was 348.55 pg/ mL (IQR=241.70-493.80 pg/mL). We found higher VEGF-1 level in mRS ≥ 3 vs mRS ≤ 2 population sub-groups (P<0.05). Using multivariate Cox regression analysis we reported that VEGF-1 (increased per 125 pg / mL) and type two diabetes mellitus (present versus absent) were found as independent predictors for favorable neurologic recovery. Conclusion:In Conclusion, We found that VEGF-1 (increased per 125 pg / mL) measured at baseline positively predicts improved neurologic recovery at six month among subjects with acute ischemic stroke who were not enrolled for invasive or thrombolytic strategy. Type two diabetes mellitus (present versus absent) were found as independent predictor for favorable neurologic recovery in follow up period.

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Section: Introductionmentioning

confidence: 96%

Vascular Endothelial Growth Factor-1 Level and Functional Neurologic Recovery after Ischemic Hemispheric Stroke

Medvedkova¹,

Berezin²

2015

Neurochem Neuropharm

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Assessment of the diagnostic significance of modern biomarkers and hemodynamic alterations in workers of vibration-hazardous occupations

Melentev

Oshkoderov

2021

Zdravoohran. Ross. Fed.

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Introduction. One of the most significant tasks in modern labor medicine is to reduce the indicators of early disability in persons in contact with harmful and dangerous factors of the production environment. The issue of finding markers of early preclinical manifestations of vibrational disease and establishing comorbid conditions that are prognostically unfavorable for the course of the underlying occupational disease remains relevant. The purpose of the study is assessment of diagnostic significance of current neurospecific biomarkers and hemodynamic changes in workers of the profession related to vibration. Material and methods. The results of two studies were the basis for this work. The first, aimed at determining the concentration of neurospecific markers in the blood of miners, includes 154 working vibration hazardous professions. At the same time, groups were identified depending on the type of exposure to vibration: total (69 workers), local (24 workers) and combined general and local (61 miners) and control group of workers not in contact with vibration (49 people). The second study was performed to assess the change in hemodynamic parameters among 216 industrial workers, of which 114 people were in contact with vibration generating equipment, and 102 workers were included in the control group. Results. Data from the first study showed an increase in the titer of neuron-specific indicators, mainly protein S100B, depending on the type of exposure vibration and its seniority dose. The second study results indicated an increase in systolic blood pressure and total peripheral vascular resistance in miners under exposure to vibration factor. Conclusion. The results of both studies suggest that hemodynamic disorders and changes in the performance of neuro specific proteins may be interconnected. It seems advisable to continue the study in workers in vibrant occupations with comorbid pathology.

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Predictive Value of Circulating Vascular Endothelial Growth Factor-1 in Arterial Hypertension Patients

Cited by 2 publications

References 33 publications

Vascular Endothelial Growth Factor-1 Level and Functional Neurologic Recovery after Ischemic Hemispheric Stroke

Vascular Endothelial Growth Factor-1 Level and Functional Neurologic Recovery after Ischemic Hemispheric Stroke

Assessment of the diagnostic significance of modern biomarkers and hemodynamic alterations in workers of vibration-hazardous occupations

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