Predictive value of ADC mapping in discriminating probably benign and suspicious breast lesions

Abowarda, Mohamed Hamed; Hasan, Doaa Ibrahim; Elteeh, Osama Abdelaziz

doi:10.1016/j.ejrnm.2015.02.004

Cited by 6 publications

(2 citation statements)

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“…4 ) with consistently lower mean ADC values (1.0 × 10 −3 mm 2 /s) than what is observed for normal breast parenchyma (2.3 × 10 −3 mm 2 /s). Our mean ADC values for IGM are close to those identified for suspicious breast lesions [ 32 ] and similar to what is reported for granulomatous inflammation of the prostate [ 33 ]. Presumably, the chronic inflammatory response in IGM results in reduced water diffusion capacity and decreased relative ADC values.…”

Section: Discussionsupporting

confidence: 89%

Idiopathic granulomatous mastitis: imaging update and review

et al. 2016

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ObjectivesThe purpose of this study was to review the imaging features of idiopathic granulomatous mastitis (IGM) with clinical and pathology correlation.MethodsWith institutional review board (IRB) approval, a retrospective search of the surgical pathology database from January 2000 to July 2015 was performed. Clinical, imaging and histology findings were reviewed. Cases of granulomatous mastitis without a known source, diagnosed with percutaneous or surgical biopsy, were included in our analysis.ResultsSeventeen cases of IGM were identified with imaging available for review. The majority of patients presented with a palpable abnormality, whereas a minority were asymptomatic with an abnormal screening mammogram. At imaging, IGM most often demonstrated a focal asymmetry at mammography, a hypoechoic mass with irregular or angular margins at ultrasound, and robust enhancement with mixed progressive and plateau kinetics at magnetic resonance imaging (MRI). Axillary lymph nodes were reactive in appearance at ultrasound. Molecular breast imaging performed in one case showed mild focal asymmetric radiotracer uptake.ConclusionIGM is a rapidly progressive rare inflammatory condition of the breast resulting in non-necrotizing granuloma formation. Imaging features mimic breast carcinoma and diagnosis can be difficult. Radiologists’ awareness of this condition is essential to prevent delayed or unnecessary treatment.Teaching points• Idiopathic granulomatous mastitis is rapidly progressive inflammatory condition.• Imaging features may mimic breast carcinoma or infection.• Ultrasound shows irregular hypoechoic masses with increased vascularity and sinus tracts.• MRI shows irregular, enhancing masses or non-mass enhancement with microabscesses.• MRI is useful for assessment of breast involvement and response to treatment.

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Section: Discussionsupporting

confidence: 89%

Idiopathic granulomatous mastitis: imaging update and review

et al. 2016

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“…Similarly, we noted in the previous studies [8,[13][14][15][16][17][18][19]] they have reported detection and evaluation of breast lesions in DWI with multiple b value ranging from 250 -1500 s/ mm 2 and with variable ADC cut off value. Studies that used low b value ranging from 250-800 s/mm 2 have reported slightly higher ADC values for both benign and malignant lesion as compared to studies that used b values of 1000-1500 s/mm 2 .…”

Section: Discussionsupporting

confidence: 80%

Quantitative Evaluation for Differential Diagnosis of Breast Lesions in Diffusion-Weighted MR Imaging

2021

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Diffusion-weighted MR Imaging is a rapidly emerging technique, that allows in-vivo mapping processes of the water diffusion in tissues. It has the potential capabilities for clinical application in breast imaging. The aim of this study was to find out the optimal b-value for calculation of ADC value for differential diagnosis of breast lesions. A total of 124 subjects (mean age 46 years) with 141 lesions were included. The protocol consists of axial T2 sequence for lesion localization and measurement and DW sequence with three sets of b-values of 0, 300, 600, and 1000 s/mm2. The mean ADC values of the breast lesions for b-values (0, 300, 600, and 1000) were 1.75 ± 0.18 × 10−3mm2/sec, 1.66 ± 0.12 × 10−3mm2/sec and 1.57 ± 0.15 × 10−3mm2/sec for the benign lesions and 1.26 ± 0.048 × 10−3mm2/sec, 1.14 ± 0.11 × 10−3mm2/sec and 0.93 ± 0.14 × 10−3mm2/sec for malignant lesions respectively. Statistical significant differences were noted on the ADC value of benign and malignant lesions among the three sets of b values (p = 0.001). ADC values of malignant lesion was significantly lower compared to benign lesions. The AUC (0.998) was substantially large for b-value of 0,600 s/mm2 with a threshold ADC cut off value of 1.28 × 10−3mm2/sec with 98.4% sensitivity, 93.2% specificity and 98.5% positive predictive value(PPV). In conclusion, diffusion weighted imaging has the ability for differential diagnosis of breast lesions with the optimal b value of 0,600 s/ mm2. DWI is a reliable tool for characterising breast lesions and may increase the overall specificity of breast MRI.

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Breast Lesions: Diagnosis Using Diffusion Weighted Imaging at 1.5T and 3.0T—Systematic Review and Meta-analysis

Shi

Yao

et al. 2018

Clinical Breast Cancer

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Predictive value of ADC mapping in discriminating probably benign and suspicious breast lesions

Cited by 6 publications

References 30 publications

Idiopathic granulomatous mastitis: imaging update and review

Idiopathic granulomatous mastitis: imaging update and review

Quantitative Evaluation for Differential Diagnosis of Breast Lesions in Diffusion-Weighted MR Imaging

Breast Lesions: Diagnosis Using Diffusion Weighted Imaging at 1.5T and 3.0T—Systematic Review and Meta-analysis

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