Predictive Roles of Basal Metabolic Rate and Body Water Distribution in Sarcopenia and Sarcopenic Obesity: The link to Carbohydrates

Guan, Lizheng; Li, Tiantian; Wang, Xuan; Yu, Kang; Xiao, Rong; Xi, Yuandi

doi:10.3390/nu14193911

Cited by 7 publications

(3 citation statements)

References 44 publications

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“…From the above results, it can be seen that the factors leading to the increase of ECW/TBW in tumor patients are complicated, and the extracellular water ratio of tumor patients may increase with the increase of age, disease progression, decrease of behavior ability, aggravation of malnutrition, decrease of body fat content, loss of body weight, decrease of protein level and aggravation of anemia. SMI does not show a correlation with ECW/TBW, which is very different from other studies [11][12][13].…”

Section: Explanation Of Ecw/tbw Univariate Analysis Resultscontrasting

confidence: 99%

Analysis of factors influencing the increase of extracellular water ratio in tumor patients without edema signs

heling

panpan

jie

et al. 2023

Preprint

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Objective To analyze the factors influencing the increase of extracellular water/total body water (ECW/TBW) in tumor patients lacking edema signs, and to provide reference for the diagnosis and timely management of early water retention in tumor patients. Methods 274 tumor patients admitted to Anqing First People's Hospital affiliated to Anhui Medical University during 2020.12-2022.12 were selected, excluding clinically observable edema. General clinical data, main laboratory test results and body composition indexes were collected,and the valuable variables were screened for linear regression analysis with ECW/TBW based on professional knowledge and univariate analysis results. Results Age, gender, hemoglobin, serum sodium,serum potassium and phase angle (PA) were independent influencing factors for elevated ECW/TBW. ECW/TBW increased with increasing age (partial regression coefficient B=0.009, P=0.001), ECW/TBW was higher in males than in females (B=-0.349, P<0.001), and hemoglobin (Hgb) negatively affected ECW/TBW (B=-0.003, P=0.039). Blood sodium positively affected ECW/TBW (B=0.019, P=0.011), while blood potassium had a negative effect (B=-0.180, P=0.001). PA was the factor with the greatest influence on ECW/TBW of all independent variables (B=-1.006, P<0.001). However, Performance Status (PS) score, Patient-Generated Subjective Global Assessment(PG-SGA) score, tumor stage, prealbumin, albumin, and body fat percentage were not independent influences for elevated ECW/TBW. Conclusion The early influencing factors of water retention in tumor patients are mainly due to the abnormal function of cell membrane, but also affected by age, gender, anemia and electrolyte, and timely body composition testing can help in the next intervention decision making.

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Section: Explanation Of Ecw/tbw Univariate Analysis Resultscontrasting

confidence: 99%

Analysis of factors influencing the increase of extracellular water ratio in tumor patients without edema signs

heling

panpan

jie

et al. 2023

Preprint

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“…An increase in ECW/ICW and ECW/TBW can be considered an indicator of loss of muscle mass ( 38 ). ECW/ICW can be used as an independent parameter for assessing weight gain after nutritional therapy in patients with COPD ( 16 ).…”

Section: Discussionmentioning

confidence: 99%

Correlation between body composition and disease severity in patients with chronic obstructive pulmonary disease

Jin,

Yang,

Chen

et al. 2024

Front. Med.

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BackgroundBody composition changes are important extrapulmonary manifestations in chronic obstructive pulmonary disease (COPD) patients. This study aimed to investigate the characteristics of body composition in patients with COPD, and its correlation with disease severity.MethodsA total of 105 COPD patients admitted to Zhongshan Hospital affiliated to Dalian University, from May 1, 2021 to January 31, 2023, were included as the COPD group, and 105 subjects without COPD were enrolled as the control group during the same period. According to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) comprehensive assessment indicators, COPD patients were divided into groups: the degree of pulmonary function airflow limitation was grouped according to FEV1%pred; clinical symptoms were grouped according to mMRC scores and CAT scores; the risk of acute exacerbation was divided into low risk and high risk groups. Body composition was measured by bioelectrical impedance analysis (BIA).Results(1) Concerning body composition, the body mass index (BMI), fat-free mass index (FFMI), and angle of phase (PhA) of COPD patients were lower than those of the control group. Extracellular water-to-total body water ratio (ECW/TBW) and extra-to-intracellular water ratio (ECW/ICW) were higher than those of the control group, and the difference was statistically significant (p < 0.05). (2) There were differences in body composition among COPD patients with different severity of disease: FFMI and PhA in the mild/moderate airflow limitation group were higher than those in the severe/very severe airflow limitation group. According to mMRC scores classification, the FFMI and PhA of the less symptomatic group were higher than those of the more symptomatic group, and ECW/TBW and ECW/ICW were lower than those of the more symptomatic group. According to CAT scores classification, FFMI and PhA in the mild/moderate disease group were higher than those in the severe/very severe disease group. The FFMI of the low-risk group was higher than that of the high-risk group, and ECW/TBW was lower than that of the high risk group. (3) Correlation analysis between body composition and disease severity indicators showed that FFMI and PhA were negatively correlated with mMRC scores and CAT scores, and positively correlated with FEV1%pred. ECW/TBW ratio and ECW/ICW ratio were positively correlated with mMRC scores and CAT scores, and negatively correlated with FEV1%pred, and the difference was statistically significant (p < 0.05).ConclusionThere are significant differences in body composition between COPD patients and the control group, and there are significant differences in body composition between COPD patients with different severity of disease, with correlations between body composition and severity of disease.

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“…Over the past decades, research on BMR has mainly focused on obesity and metabolic-related diseases ( 23 ), and it has been well applied in the treatment of diabetes. BMR plays a key role in maintaining normal structure and function, and an imbalance in metabolic demands and BMR may be closely related to clinical diseases.…”

Section: Discussionmentioning

confidence: 99%

Effect of basal metabolic rate on osteoporosis: A Mendelian randomization study

Zhou

Wei

et al. 2023

Front. Public Health

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PurposeBasal metabolic rate may play a key role in the pathogenesis and progression of osteoporosis. We performed Mendelian random analysis to evaluate the causal relationship between basal metabolic rate and osteoporosis.MethodsInstrumental variables for the basal metabolic rate were selected. We used the inverse variance weighting approach as the main Mendelian random analysis method to estimate causal effects based on the summary-level data for osteoporosis from genome-wide association studies.ResultsA potential causal association was observed between basal metabolic rate and risks of osteoporosis (odds ratio = 0.9923, 95% confidence interval: 0.9898–0.9949; P = 4.005e − 09). The secondary MR also revealed that BMR was causally associated with osteoporosis (odds ratio = 0.9939, 95% confidence interval: 0.9911–0.9966; P = 1.038e − 05). The accuracy and robustness of the findings were confirmed using sensitivity tests.ConclusionBasal metabolic rate may play a causal role in the development of osteoporosis, although the underlying mechanisms require further investigation.

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Predictive Roles of Basal Metabolic Rate and Body Water Distribution in Sarcopenia and Sarcopenic Obesity: The link to Carbohydrates

Cited by 7 publications

References 44 publications

Analysis of factors influencing the increase of extracellular water ratio in tumor patients without edema signs

Analysis of factors influencing the increase of extracellular water ratio in tumor patients without edema signs

Correlation between body composition and disease severity in patients with chronic obstructive pulmonary disease

Effect of basal metabolic rate on osteoporosis: A Mendelian randomization study

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