Predictive role of IL-17A/IL-10 ratio in persistent asthmatic patients on vitamin D supplement

Shabana, Marwa A.; Esawy, Marwa M.; Ismail, Nagwan A.; Said, Ahmed A.

doi:10.1016/j.imbio.2019.09.005

Cited by 20 publications

(27 citation statements)

References 38 publications

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“…Asthma biomarkers can also be used to predict response to pharmacological treatments ( 69 , 70 ). Sputum and blood eosinophils have demonstrated sensitivities of 50–79% and specificities of 69–92% for the prediction of responsiveness to oral steroid treatment ( 70 ).…”

Section: Resultsmentioning

confidence: 99%

Diagnostic Accuracy of Liquid Biomarkers in Airway Diseases: Toward Point-of-Care Applications

et al. 2022

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BackgroundLiquid biomarkers have shown increasing utility in the clinical management of airway diseases. Salivary and blood samples are particularly amenable to point-of-care (POC) testing due to simple specimen collection and processing. However, very few POC tests have successfully progressed to clinical application due to the uncertainty and unpredictability surrounding their diagnostic accuracy.ObjectiveTo review liquid biomarkers of airway diseases with well-established diagnostic accuracies and discuss their prospects for future POC applications.MethodologyA literature review of publications indexed in Medline or Embase was performed to evaluate the diagnostic accuracy of liquid biomarkers for chronic obstructive pulmonary disease (COPD), asthma, laryngopharyngeal reflux (LPR), and COVID-19.ResultsOf 3,628 studies, 71 fulfilled the inclusion criteria. Sputum and blood eosinophils were the most frequently investigated biomarkers for the management of asthma and COPD. Salivary pepsin was the only biomarker with a well-documented accuracy for the diagnosis of LPR. Inflammatory blood biomarkers (e.g., CRP, D-dimers, ferritin) were found to be useful to predict the severity, complications, and mortality related to COVID-19 infection.ConclusionMultiple liquid biomarkers have well-established diagnostic accuracies and are thus amenable to POC testing in clinical settings.

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Section: Resultsmentioning

confidence: 99%

Diagnostic Accuracy of Liquid Biomarkers in Airway Diseases: Toward Point-of-Care Applications

et al. 2022

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“…The characteristics and baseline data of included RCTs were presented in Tables 1 , 2 In this review, all the included studies were RCTs, including the detailed information of 1,349 subjects, with the sample size ranging from 15 to 207, and the locations of the subjects involved in the United States ( 76 ), Holland ( 77 ), United Kingdom ( 78 ), Egypt ( 79 ), Poland ( 80 ), Pakistan ( 81 ), and India ( 73 , 74 , 82 , 83 ).…”

Section: Resultsmentioning

confidence: 99%

“…Among the 10 included studies, one RCT ( 74 ) included patients with allergic bronchopulmonary aspergillosis (ABPA) complicating asthma, whereas the other nine RCTs included patients with asthma ( 73 , 76 – 81 ) or moderate persistent asthma ( 82 , 83 ). In addition, six studies in which participants were adults ( 74 , 76 – 79 , 81 ), while the other four RCTs were children ( 73 , 80 , 82 , 83 ).…”

Section: Resultsmentioning

confidence: 99%

“…Asthma exacerbations were used as an outcome in Castro’s ( 76 ), Dodamani’s (74) , Yadav’s ( 83 ), and Musharraf’s ( 81 ) studies. The rest of one RCT ( 79 ) used FEV1 to evaluate the outcome of the two groups.…”

Section: Resultsmentioning

confidence: 99%

“…Baseline FEV1 values were reported in seven studies in the two groups, six of which were greater than 70% ( 73 , 76 – 78 , 80 , 82 ), whereas one of which was less than 70% ( 79 ). Three RCTs reported FENO baseline values, two of which were higher than those in the intervention group ( 77 , 82 ), and the other was the opposite ( 78 ).…”

Section: Resultsmentioning

confidence: 99%

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A Meta-Analysis on Vitamin D Supplementation and Asthma Treatment

2022

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BackgroundVitamin D, as an immunomodulator, may be related to the therapeutic effect of asthma patients, but the research in this area is still controversial. The aim of this meta-analysis was to analyze the role of vitamin D supplementation in the treatment of asthma patients.Materials and MethodsRandomized Controlled Trials (RCTs) of vitamin D supplementation in asthma were searched in PubMed, EMBASE, and the Cochrane library. Primary outcomes were forced expiratory volume in one second (FEV1), asthma exacerbations, Asthma Control Test scores (ACT scores), and fractional exhaled nitric oxide (FENO).ResultsA total of 10 RCTs were included, including 1,349 patients. Vitamin D supplementation didn’t affect the ACT scores (SMD = 0.04, 95% CI = −0.13 to 0.21, P = 0.87), FEV1 (SMD = 0.04, 95% CI = −0.35 to 0.43, P < 0.01) and FENO (SMD = −0.01, 95% CI = −0.22 to 0.20, P = 0.27), but reduced the rate of asthma exacerbations (RR = 0.69, 95% CI = 0.41 to 0.88, P < 0.01), especially in subgroups of children (RR = 0.46, 95% CI = 0.30 to 0.70, P = 0.83) and follow up time less than 6 months (RR = 0.45, 95% CI = 0.32 to 0.63, P = 0.95). Additionally, though there was only one study included in the subgroup, it significantly enhanced FEV1 at the last visit for patients whose FEV1 baseline value was less than 70% (SMD = 0.94, 95% CI = 0.47 to 1.41).ConclusionVitamin D supplementation can reduce asthma exacerbations, especially in children, and within 6 months of follow up time. In addition, vitamin D has a positive effect on improving FEV1 of patients whose FEV1 baseline value is less than 70%, but more RCTs are still needed to support this conclusion.Systematic Review Registration[https://inplasy.com], identifier [10.37766/inplasy20 22.6.0049].

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Nutrition and asthma

Stephensen

Kenyon²

2023

Encyclopedia of Human Nutrition

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Predictive role of IL-17A/IL-10 ratio in persistent asthmatic patients on vitamin D supplement

Cited by 20 publications

References 38 publications

Diagnostic Accuracy of Liquid Biomarkers in Airway Diseases: Toward Point-of-Care Applications

Diagnostic Accuracy of Liquid Biomarkers in Airway Diseases: Toward Point-of-Care Applications

A Meta-Analysis on Vitamin D Supplementation and Asthma Treatment

Nutrition and asthma

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