Predictive Perinatal Score in the Diagnosis of Neonatal Sepsis

Abstract

A scoring system for prediction of neonatal sepsis was evolved after determining the interdependence of perinatal risk factors for infection. Records of 100 babies with a history of one or more perinatal risk factors were analysed for incidence of infection within 4 hours of birth and followed for 1 week thereafter for appearance of any clinical or laboratory signs of infection. The incidence of sepsis was compared amongst various risk factors. Since majority of perinatal risk factors occur in combinations interdependence of factors was determined using actuarial analysis and score assignment was done whether the factor was dependent or independent. No definite infection was seen in the control group of 100 babies having no history of high risk factors. The scoring system thus elucidated is recommended as a screening procedure for selecting of neonates for laboratory evaluation.

A study on validity of C-reactive protein in deciding the duration of antibiotic therapy in suspected neonatal bacterial infection

“…16,17 Although incidence ranging from 20% to 85% has been reported by Sharma A et al and Somu N et al respectively. 12,18 The incidence of gram negative organism is (77.2%) and gram positive organism is (22.7%).…”

Neonatal Sepsis: A Profile of a Changing Spectrum

“…Though, some studies highligh ng hospital acquired infec ons in ins tu onal deliveries have shown this diff erence to be of less importance 20 . Since there is no single test that can be confi dently relied upon for diagnosis and as the clinical manifesta ons of sepsis are protean, its diagnosis relies mainly on assessing the risk factor predisposi on 15 , clinical syndrome 14 and ba ery of tests 13 . We used a combina on of all these to include babies in our study, keeping blood culture posi vity as gold standard.…”

“…13,15 In view of these varied factors, sepsis in neonates is o en encountered with varied presenta ons such as clinical sepsis with either sep c screen posi vity or nega vity, culture posi ve sepsis with or without meningi s. In addi on, babies could receive an bio cs for presence of maternal risk factors for EONS 13,15 . Hence this study was conducted to study the profi le of neonates presen ng with two or more of the pre defi ned criteria of clinical features of sepsis with or without maternal risk factors, to assess the outcomes in terms of micro organisms cultured, sep c screen posi vity and clinical outcomes.…”

A study of Acute Kidney Injury (AKI) in Neonatal Sepsis

“…11 Dehydration was defined as a weight loss of more than 10% of the birth weight at the end of the 1st week of life or clinical findings of dehydration with hypernatremia. 12 Respiratory distress syndrome was defined on the basis of clinical (downe score in term, Silverman Anderson score in preterm), laboratory (ABG showing respiratory acidosis), radiological findings ( x-ray opacities) and respiratory support for >6 hours within the first 24 hours after birth. Sepsis was defined as a positive blood culture or urine culture along with clinical signs of infection.…”

“…Hypernatremia and hyponatremia were defined as serum sodium concentration >150 mmol/ L and <130 mmol/L, respectively. 12 Hyperkalemia was defined as serum potassium level >7.5 mmol/L in the first day of life and >6.5 mmol/L in the remaining days. 15 Hypertension was diagnosed with systolic and diastolic blood pressures curves described by Zubrow et al 16 Liver failure was defined by the elevated levels of aspartate aminotransferase and alanine aminotransferase that were three times higher than upper limit normal values.…”