Predictive Markers for Mother-to-Child Transmission of HIV-1 in Dar es Salaam, Tanzania

Bredberg-R??d??n, U.; Urassa, Willy; Urassa, Ernest J.N.; Lyamuya, Eligius; Msemo, Georgina; Kawo, G.; Kazimoto, Theodora; Massawe, Augustine; Grankvist, Olov; Mbena, E.; Karlsson, Katarina; Mhalu, Fred; Biberfeld, Gunnel

doi:10.1097/00042560-199502000-00009

Cited by 5 publications

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“…Data obtained from a subset of 224 delivering mothers from our study showed an overall p24 antigen detection rate of 5% [Jackson et al, 1993], that is comparable to other reported low rates in delivering women in Tanzania (5%) [Bredberg-Raden et al, 1995], France (9%) [Burgard et al, 1992], Switzerland (22%) [Schupbach et al, 1994], and the United States (32%) [Rich et al, 1997].…”

Section: Discussionsupporting

confidence: 84%

HIV-1 ICD p24 antigen detection in Ugandan infants: Use in early diagnosis of infection and as a marker of disease progression

et al. 2000

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The objective of this study was to determine the use of immune-complex dissociated (ICD) p24 antigen detection for the diagnosis and prognosis of HIV-1 infection in Ugandan children. Plasma collected prospectively from children born to HIV-1 infected Ugandan women was stored and later analyzed for the presence of neutralizable HIV-1 p24 antigen using the Coulter ICD p24 antigen and neutralization kits. HIV-1 infection status, disease progression, and survival of the children were determined. Specimens from 311 children born to HIV-1 infected women, including 138 HIV-1 infected children, and 113 children born to negative women were tested. Sixty-nine (50%) infected children were p24 antigen positive at least once. For early HIV-1 diagnosis, the specificity and positive predictive value of the assay were consistently high (>95% and >83% respectively), but the sensitivity was low (6-53%), especially in the first months of life. The presence of p24 antigenemia in the first two years of life was associated with poor survival (20%) by 80 months of age compared with infected children without antigenemia (43%, P < 0.001). Early detection of p24 antigen (6 months, P < 0.001). The data suggest that ICD p24 antigen detection is not a sensitive method for the determination of infant HIV-1 status in our cohort of HIV-1 infected Ugandan children tested in the first two years of life. There was a strong correlation, however, between the presence and time of onset of p24 antigenemia and mortality among HIV-1 infected children.

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Section: Discussionsupporting

confidence: 84%

HIV-1 ICD p24 antigen detection in Ugandan infants: Use in early diagnosis of infection and as a marker of disease progression

et al. 2000

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“…The utility of T-lymphocyte counts for predicting mortality has been reported in studies conducted among HIV-1 infected children and adults in Africa (19,20). Low T-lymphocyte levels are also predictive of mother-to-infant transmission of HIV-1 (21,22).…”

Section: T-lymphocyte Levelsmentioning

confidence: 97%

“…These markers have been shown useful in estimating an HIV-infected individual's risk of developing AIDS (13), and have therefore been recommended as additional or alternative markers for monitoring prognosis in HIV-infected persons. Additionally, microglobulin has been shown to be a predictive marker for mother-to-infant transmission of HIV-1 (22). Assays for some of these factors, especially microglobulin and neopterin, may be affordable in resourcescarce settings, thus making their use attractive for monitoring the disease in infected individuals in Africa.…”

Section: Soluble Markersmentioning

confidence: 99%

Monitoring Immune Function

Biberfeld

Lyamuya

AIDS in Africa

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Effect of human immunodeficiency virus infection on serum beta2-microglobulin levels in pregnant women

Bardeguez¹

1999

Obstetrics & Gynecology

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Predictive Markers for Mother-to-Child Transmission of HIV-1 in Dar es Salaam, Tanzania

Cited by 5 publications

References 0 publications

HIV-1 ICD p24 antigen detection in Ugandan infants: Use in early diagnosis of infection and as a marker of disease progression

HIV-1 ICD p24 antigen detection in Ugandan infants: Use in early diagnosis of infection and as a marker of disease progression

Monitoring Immune Function

Effect of human immunodeficiency virus infection on serum beta2-microglobulin levels in pregnant women

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