Effect of human immunodeficiency virus infection on serum beta2-microglobulin levels in pregnant women

Bardeguez, Arlene

doi:10.1016/s0029-7844(99)00343-9

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…In certain conditions that activate lymphocytes, such as viral infections, ␤2-M levels may also rise. Increases in ␤2-M levels have also been described in infections caused by the human immunodeficiency virus (HIV) [43], and by cytomegalovirus [44,45]. Studies have reported that the concentration of ␤2-M can change in parallel with the treatment of hepatitis B virus infections [46,47].…”

Section: ␤2-microglobulin (␤2-m)mentioning

confidence: 99%

Factors influencing blood tumor marker concentrations in the absence of neoplasia

Trapé,

Fernández-Galán,

Auge

et al. 2024

TUB

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BACKGROUND: Tumor markers (TMs) are a heterogeneous group of molecules used in the diagnosis, prognosis and follow-up of cancer patients. During neoplastic differentiation, cells can either directly synthesize or induce the synthesis of TMs, and the release of these molecules into the bloodstream allows their quantification in biological fluids. Although very small concentrations of TMs are usually present in the serum or plasma of healthy subjects, increased concentrations may also be found in the presence of benign diseases or due to technical interference, producing false positive results. MATERIAL AND METHODS AND RESULTS: Our review analyses the causes of false positives described between January 1970 to February 2023 for the TMs most frequently used in clinical practice: α-fetoprotein (AFP), β2-microglobulin (β2-M), cancer antigen 15-3 (CA 15-3), cancer antigen CA 19-9 (CA 19-9), cancer antigen CA 72-4 (CA 72-4), cancer antigen 125 (CA 125), carcinoembryonic antigen (CEA), chromogranin A (CgA), choriogonadotropin (hCG), cytokeratin 19 fragment (CYFRA 21-1), neuron-specific enolase (NSE), human epididymis protein 4 (HE4), serum HER2 (sHER2), squamous cell carcinoma antigen (SCCA), protein induced by vitamin K absence-II (PIVKA-II), Pro-gastrin-releasing peptide (Pro-GRP), prostate-specific antigen (PSA), Protein S-100 (S-100) and thyroglobulin (Tg). A total of 247 references were included. CONCLUSIONS: A better understanding of pathophysiological processes and other conditions that affect the concentration of TMs might improve the interpretation of results and their clinical application.

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Section: ␤2-microglobulin (␤2-m)mentioning

confidence: 99%

Factors influencing blood tumor marker concentrations in the absence of neoplasia

Trapé,

Fernández-Galán,

Auge

et al. 2024

TUB

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Increased Expression of MDR1 mRNAs and P-glycoprotein in Placentas from HIV-1 Infected Women

et al. 2006

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Increased plasma concentrations of tumour markers in the absence of neoplasia

Trapé

Filella

Alsina-Donadeu

et al. 2011

Clinical Chemistry and Laboratory Medicine

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Tumour markers are a very heterogeneous group of molecules that are generally found in very small concentrations in the plasma and serum of healthy individuals. In the process of neoplastic differentiation the cell can synthesize, release, or induce synthesis of other cells, thus increasing their concentration in plasma and serum. These substances may also increase their plasma concentration in patients without cancer due to processes that increase the release or reduce catabolism, and so give rise to false positives. An understanding of the main physiopathological processes that increase the concentrations of these substances could improve our interpretation of tumour markers and their clinical application. In this study we review the physiopathological processes that may increase the plasma concentrations of tumour markers. We performed a bibliography review in PubMed, searching for causes of false positives for the following tumour markers: α-Fetoprotein, CA 125, CA 15-3, CA 19-9, CA 72-4, carcinoembryonic antigen, CYFRA 21-1, squamous cell carcinoma, prostatic specific antigen, β(2)-microglobulin, choriogonadotropin (β chain), chromogranin A, neuron specific enolase, HER2-neu, progastrin releasing peptide, S-100, and thyroglobulin. The results favour the use of tests which can identify pathological processes that may increase tumour marker concentrations.

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Effect of human immunodeficiency virus infection on serum beta2-microglobulin levels in pregnant women

Cited by 3 publications

References 17 publications

Factors influencing blood tumor marker concentrations in the absence of neoplasia

Factors influencing blood tumor marker concentrations in the absence of neoplasia

Increased Expression of MDR1 mRNAs and P-glycoprotein in Placentas from HIV-1 Infected Women

Increased plasma concentrations of tumour markers in the absence of neoplasia

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