Predictive Factors of Barrett Esophagus

Campos, Guilherme M.; DeMeester, Steven R.; Peters, Jeffrey H.; Öberg, Stefan; Crookes, Peter F.; Hagen, Jeffrey A.; Bremner, Cedric G.; Sillin, Lelan F.; Mason, Rodney J.; DeMeester, Tom R.

doi:10.1001/archsurg.136.11.1267

Cited by 98 publications

(29 citation statements)

References 45 publications

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“…Several studies have documented lower mean basal LES pressures in patients with Barrett’s esophagus compared to patients with uncomplicated GERD (fig. 1a) [8,9,10,11,12,13,14,15,16]. However, when patients with Barrett’s esophagus are compared to patients with severe reflux esophagitis only, no significant differences in LES pressures were noted [17,18,19,20].…”

Section: Lower Esophageal Sphinctermentioning

confidence: 99%

“…A strong association has been described between the presence of a hiatus hernia and Barrett’s esophagus [13,28,29,30,31,32], with a 2-cm or longer hernia found in 96% of 46 patients with Barrett’s esophagus [31]. Hiatal hernia impairs LES function [33], and the resultant lower LES pressure increases susceptibility to reflux events [34, 35].…”

Section: Hiatal Herniamentioning

confidence: 99%

“…Studies have shown that mean pressure wave amplitudes in patients with Barrett’s esophagus are lower than in normal subjects and in patients with mild reflux esophagitis [6,11,12,13,14,15,16,17,18, 20, 52, 53] (fig. 1b).…”

Section: Esophageal Dysmotilitymentioning

confidence: 99%

“…Although similar abnormalities have been implicated in symptom generation in patients with erosive and non-erosive reflux disease, patients with Barrett’s esophagus seem to have a similar or even decreased symptom burden compared to non-Barrett’s GERD patients [13, 14, 78]. Studies using esophageal acid perfusion and balloon distention reported decreased sensitivity to these stimuli in patients with Barrett’s esophagus, and this could contribute to the lower symptom perception in these patients [79].…”

Section: Esophageal Sensitivitymentioning

confidence: 99%

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The Spectrum of Motor Function Abnormalities in Gastroesophageal Reflux Disease and Barrett’s Esophagus

et al. 2009

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Barrett’s esophagus has traditionally been regarded as the most severe end of the spectrum of gastroesophageal reflux disease and is of great clinical importance in view of the association with esophageal adenocarcinoma. Studies have documented high levels of esophageal acid exposure in Barrett’s esophagus. Various pathogenetic mechanisms underlie this phenomenon. These include abnormalities in esophageal peristalsis, defective lower esophageal sphincter pressures, gastric dysmotility and bile reflux. Whilst these factors provide evidence for an acquired cause of Barrett’s esophagus, an underlying genetic predisposition cannot be ruled out. Although the past decade has brought about many new discoveries in the pathogenesis of Barrett’s esophagus, it has also added further controversy to this complex disorder. A detailed analysis of the gastrointestinal motor abnormalities occurring in Barrett’s esophagus follows, with a review of the currently available literature and an update on this condition that continues to be of interest to the gastroenterologist.

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Section: Lower Esophageal Sphinctermentioning

confidence: 99%

Section: Hiatal Herniamentioning

confidence: 99%

Section: Esophageal Dysmotilitymentioning

confidence: 99%

Section: Esophageal Sensitivitymentioning

confidence: 99%

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The Spectrum of Motor Function Abnormalities in Gastroesophageal Reflux Disease and Barrett’s Esophagus

et al. 2009

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“…19 Campos et al found strong correlation between the prescence of bile reflux with the occurence of intestinal metaplasia. 20 This study found that 5,9% BE cases was accompanied with bile reflux.…”

Section: B D Cmentioning

confidence: 78%

Histopathological Diagnostic Criteria of Barrett Esophagus and Its Association With Endoscopy Findings

Rustiasari

Handjari

2017

JKKI

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45Background: In the last decades, the incidence of esophageal adenocarcinoma has significantly increased. Barrett Esophagus (BE) is widely known as a precursor lession of esophageal adenocarcinoma, and it could increase the risk of adenocarcinoma to 30-120 times higher than non-BE patient. The controversy about BE definition is still a problem amongst pathologist. BE is defined as the transition of normal esophageal squamous epithellium into metaplastic columnar epithellium that can be seen through endoscopy at the upper region of gastroesophagus transitional area, and confirmed with hystological examination. Objective: To re-evaluate hystopathological presentation of BE and the classification of dysplasia as well as its association with clinical finding in the form of endoscopy results. Methods: Clinical and hystopathological datas of 71 cases of BE was collected and re-evaluated based on British Society of Gastroenterology Guidelines 2005 criteria, as well as re-evaluating the grade of dysplasia based on WHO Classification of tumours of the digestive system 2010. Results: 51 cases of BE were obtained with male:female ratio 33:18 patients. BE cases were predominated by 51-60 years old age group, in which the mean of patients age was 55 years old. The results of dysplasia grade re-evaluation showed 72,55% non-dysplasia BE case, 3,9% was BE indefinite; 23,53% was BE with low grade dysplasia; and 1,97% was BE with hard grade dysplasia. There were 15 cases (21,12%) that were changed in diagnosis, from BE to non-BE cases. Conclusion:The diagnosis of BE could be made if there are compatibility between endoscopy examination and hystopathological examination, in which BE presentations was found, either in category 1, 2 or 3based on British Society of Gastroenterology Guidelines 2005 and endoscopy indicated supicion of BE. Changes in diagnosis of BE cases into non-BE cases could happen not because there are incompatibilities of the results of these examinations. This might happen due to nescience regarding the importance of the results of endoscopy examination and its compatibility with the results of hystopathological examination.

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Gastroesophageal Reflux Disease, Barrett Esophagus, and Esophageal Adenocarcinoma

Chang

Katzka²

2004

Arch Intern Med

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The incidence of esophageal adenocarcinoma has been rising rapidly over the past few decades. The major risk factors predisposing to the development of adenocarcinoma are long-standing gastroesophageal reflux disease and Barrett esophagus, but other factors may be involved as cancer can occur in their absence. In patients with Barrett esophagus, the extent and degree of dysplasia influence the risk of esophageal adenocarcinoma. As neither medical nor surgical therapies have been proven to prevent adenocarcinoma, endoscopic screening of patients with chronic reflux and endoscopic surveillance of patients diagnosed with Barrett esophagus are usually performed in an effort to detect adenocarcinomas at earlier stages. The evidence supporting strategies in the management of patients with gastroesophageal reflux and Barrett esophagus is presented.

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Predictive Factors of Barrett Esophagus

Cited by 98 publications

References 45 publications

The Spectrum of Motor Function Abnormalities in Gastroesophageal Reflux Disease and Barrett’s Esophagus

The Spectrum of Motor Function Abnormalities in Gastroesophageal Reflux Disease and Barrett’s Esophagus

Histopathological Diagnostic Criteria of Barrett Esophagus and Its Association With Endoscopy Findings

Gastroesophageal Reflux Disease, Barrett Esophagus, and Esophageal Adenocarcinoma

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