Predictive Factors for Early-Onset Seizures in Patients With Cerebral Venous Sinus Thrombosis

Mu, Shuwen; Li, Jun; Lin, Kunzhe; Fang, Y.; Li, Feng; Li, Ziqi; Xu, Yue; Wang, Shousen

doi:10.3389/fneur.2022.842807

Cited by 7 publications

(2 citation statements)

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“…The incidence of cerebral venous sinus thrombosis (CVST) is reported to be 3-4/1,000,000 and accounts for 1% of all strokes 1 . CVST, which occurs in younger age groups compared to other stroke types, may present with headache alone or with focal neurologic findings, seizures, and coma.…”

Section: Introductionmentioning

confidence: 99%

Sinus vein thrombosis and epileptic seizures: outcomes of long term follow-up

PEKÖZ,

DEMİR

2023

Cukurova Medical Journal

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Purpose: In the acute phase of Cerebral Venous Sinus Thrombosis (CVST), approximately 35-50 % of patients diagnosed epileptic seizures. This study aimed to investigate the demographic and clinical characteristics, frequency of seizures, prognosis of patients during a one-year follow-up period. Materials and Methods: The files of patients who were followed up with the diagnosis of acute ischemic stroke between January 1, 2018 and January 1, 2022 were evaluated in this retrospective study. Demographic features, presence of seizure history and seizure frequency, neuroimaging findings, affected cerebral venous sinuses, and anti-seizure medication use were recorded. Results: A total of 701 patients with acute stroke had their medical records reviewed. Thirty-two of 701 patients (4.56 %) were diagnosed with CVST; 37.5 % of patients experienced early-onset seizures. Seizure control was achieved with monotherapy in 88.8 % (n:8) of patients with seizures. Involved sinuses in patients with seizures; 50 % (n=6) superior sagittal sinus was the most commonly involved sinus and inferior sagittal sinus and sinus rectus were not involved. In terms of sinus involvement, there was no statistically significant difference between patients with and without seizures. On cerebral magnetic resonance imaging, venous infarcts were detected in 66.7 % (n=8) of patients with seizures, compared to 35 % of patients without seizures. Conclusion: This retrospective study revealed that seizures typically occur early in the disease, have a favorable prognosis over the long term, and can be managed with monotherapy.

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Section: Introductionmentioning

confidence: 99%

Sinus vein thrombosis and epileptic seizures: outcomes of long term follow-up

PEKÖZ,

DEMİR

2023

Cukurova Medical Journal

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“…COVID-19 спровоцировал развитие коагулопатий со вторичным антифосфолипидным синдромом (АФС) у пациентов с генетическими мутациями и признаками дисплазии. Увеличилась доля выявляемости приобретенной или врожденной тромбофилии [6]. Тромбофилия любой этиологии, АФС, гипергомоцистеинемия -наиболее распространенные факторы риска развития венозных осложнений [7].…”

Section: Introductionunclassified

A young patient at a neurologist’s appointment: features of diagnostics and therapy

Путилина

2023

Medicinskij sovet

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Outpatient neurological appointments in most cases consist of patients older than 45 years. The novel coronavirus pandemic has changed this statistic. Young patients began to turn to polyclinics more often with complaints of headache, feeling of weakness, decreased physical activity, forgetfulness, and changes in concentration. COVID-1 9 provoked the development of coagulopathy in patients with genetic mutations and signs of dysplasia. The percentage of patients with acquired or congenital thrombophilia has increased. Most of them had certain manifestations of undifferentiated dysplasia, with signs of impaired venous outflow with a characteristic cephalgic syndrome. The peculiarity of which is polymorphism, inconstancy, the absence, in most cases, of connection with specific vascular and hemodynamic factors (excluding headache in venous thrombosis), a decrease in the frequency of occurrence as the disease progresses. The presence of certain complaints (headache, asthenia, cognitive impairment) requires the appointment of specific therapy. Monotherapy with one drug, even if it has a pleiotropic effect, does not always achieve therapeutic goals, since one or another mechanism of pharmacological action prevails, and the rest are secondary, requiring enhancement or other drugs, or non-drug methods. Given the poor adherence of young patients to treatment, the way out of this situation is the use of combined drugs. Combination drugs can be used as multifunctional drugs, potentiating or summarizing their effects, while reducing the risk of polypharmacy and unwanted side reactions. One of the most promising combinations is Picamilon Ginkgo (Ginkgo biloba leaf extract + Nicotinoyl gamma-a minobutyric acid), which has established itself as an effective corrector of asthenia and cognitive impairment in patients of any age.

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