Predictive factors associated with increased progression to dialysis in early chronic kidney disease (stage 1–3) patients

Nohara, Nao; Io, Hiroaki; Matsumoto, Mayumi; Furukawa, Masashi; Okumura, K; Nakata, Jun; Shimizu, Yoshio; Horikoshi, Satoshi; Tomino, Yasuhiko

doi:10.1007/s10157-015-1210-3

Cited by 6 publications

(5 citation statements)

References 35 publications

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“…More complications may develop with worse CV status in these patients, which may also worsen the prognosis by creating a "vicious circle". Nohara et al described that in early CKD (stages 1-3) patients, LVMI, urinary protein, and Hb levels were independently associated with factors for progression to dialysis [48]. Similarly in our cohort, there was also an independent association between LVMI and Hb, but not with urinary protein.…”

Section: Discussionsupporting

confidence: 79%

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Left ventricular myocardial mass index associated with cardiovascular and renal prognosis in IgA nephropathy

Sági

Késői²,

Vas

et al. 2022

BMC Nephrol

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Introduction In chronic kidney disease (CKD), like in IgA nephropathy (IgAN), cardiovascular (CV) mortality and morbidity are many times higher than in the general population, and left ventricular hypertrophy (LVH) is an independent risk factor for CV disease. This follow-up study investigated the association between left ventricular mass index (LVMI) and renal or cardiovascular outcomes. Methods We examined 118 IgAN patients prospectively. LVMI and LV geometry was investigated using echocardiography. The primary combined endpoints were total mortality, major CV events, and end-stage renal disease. Secondary endpoints, i.e.—cardiovascular or renal endpoints,—were also examined separately. Results Sixty seven percent were males, mean age 53.5 ± 13.5. Mean follow-up time: 184 months. LVMI inversely correlated with eGFR (corr. coefficient: -0.365; p < 0.01). We divided the patients into two groups based on the LVMI cut-off suggested by the literature. The presence of LVH caused a worse prognosis in primary (p < 0.001), renal endpoints (p = 0.01), and also in CV endpoints (p = 0.001). The higher LVMI in men significantly worsened the prognosis in all endpoints. Concentric hypertrophy meant a worse prognosis. Independent predictors of LVMI were gender and eGFR in uni- and multivariate regression and hemoglobin levels only in logistic regression. Independent predictors of the primary endpoint were LVMI, eGFR, gender, obesity, HT, DM, and metabolic syndrome in Cox regression analysis. Conclusion Increased LVMI may predict the progression to end-stage renal disease and CV events in IgAN. Determining LVMI may be a useful parameter not only in CV risk but also in the stratification of renal risk in CKD.

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Section: Discussionsupporting

confidence: 79%

“…Nohara et al described that in early CKD (stages 1–3) patients, LVMI, urinary protein, and Hb levels were independently associated with factors for progression to dialysis [ 48 ]. Similarly in our cohort, there was also an independent association between LVMI and Hb, but not with urinary protein.…”

Section: Discussionmentioning

confidence: 99%

Left ventricular myocardial mass index associated with cardiovascular and renal prognosis in IgA nephropathy

Sági

Késői²,

Vas

et al. 2022

BMC Nephrol

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“…Several studies reported the useful marker for predicting renal outcome, such as systolic blood pressure, urinary protein, hemoglobin and left ventricular mass index [12][13][14]. Generally, it is difficult to predict the progression of kidney function at an early stage of CKD since patients with CKD shows no symptoms or only slightly changes in laboratory data, such as serum creatinine, cystatin C, or urinary protein excretion.…”

Section: Discussionmentioning

confidence: 98%

Plasma neutrophil gelatinase-associated lipocalin (NGAL) is an indicator of interstitial damage and a predictor of kidney function worsening of chronic kidney disease in the early stage: a pilot study

et al. 2017

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“…Compared with non‐anaemic counterparts, patients with anaemia of CKD have an increased risk of hospitalisations, 5 cardiovascular (CV) events, 6 heart failure, 7 progression to dialysis dependence 8 and all‐cause mortality. 9 Comorbid diabetes is linked to an increased prevalence of anaemia in CKD, 10 with greater frequency and higher severity 11 in later CKD stages.…”

Section: Introductionmentioning

confidence: 99%

Challenging patient phenotypes in the management of anaemia of chronic kidney disease

Pramod

Goldfarb

2021

Int J Clin Pract

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Anaemia affects ~15.4% of patients with chronic kidney disease (CKD) in the US, an estimated 5.7 million people. 1,2 Anaemia prevalence increases with CKD stage, ranging from 8% at stage 1 to 53% at stage 5, 1 and with age, with 28% in patients aged 18-63 years and 50% in patients aged 66-85 years. 3 Race/ethnicity and sex also impact the prevalence of anaemia of CKD with increased risk in Black, Hispanic and female patients. 4

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Predictive factors associated with increased progression to dialysis in early chronic kidney disease (stage 1–3) patients

Abstract: This study of patients in early CKD demonstrated that higher LVMI and urinary protein and that lower levels of hemoglobin in blood were associated with progression to dialysis. LVMI evaluated by echocardiography may identify a high risk of progression to dialysis in early CKD patients.

Cited by 6 publications

References 35 publications

Left ventricular myocardial mass index associated with cardiovascular and renal prognosis in IgA nephropathy

Left ventricular myocardial mass index associated with cardiovascular and renal prognosis in IgA nephropathy

Plasma neutrophil gelatinase-associated lipocalin (NGAL) is an indicator of interstitial damage and a predictor of kidney function worsening of chronic kidney disease in the early stage: a pilot study

Challenging patient phenotypes in the management of anaemia of chronic kidney disease

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