Predictive factors and incidence of anxiety and depression in a cohort of HIV-positive patients in French Guiana

Nacher, Mathieu; Adriouch, Leïla; Godard‐Sebillotte, Claire; Hanf, Matthieu; Vantilcke, Vincent; Guedj, Myriam El; Vaz, Tânia; Leconte, Constance; Simart, Genevieve; Djossou, Marie-Laure; Couppié, Pierre

doi:10.1080/09540121003599232

Cited by 32 publications

(35 citation statements)

References 21 publications

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“…In French Guiana, the incidence rate of first observed depression in HIV-infected patients was 1.89 per 100 person-years. 10 Our results are similar to those published in French Guiana. However, in the present study, there was no statistically significant association of depression with anxiety, or nationality (these variables were thus dropped from our final model), as opposed to the findings in French Guiana.…”

Section: Discussionsupporting

confidence: 94%

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Incidence and predictive factors of depression among patients with HIV infection in Guadeloupe: 1988–2009

et al. 2013

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A retrospective cohort study was conducted to determine the incidence and the predictive factors of depression in a cohort of 2737 HIV/AIDS-infected patients in Guadeloupe followed for a total of 8402 patient-years. The incidence rate of first observed depression was 2.2 per 100 person-years (95% confidence interval [CI], 1.9-2.6). A single failure Cox proportional hazards model showed that the 1997-2000 inclusion period (hazard ratio [HR] ¼ 1.60; 95% CI ¼ 1.10-2.40; p ¼ 0.01), the 2001-2009 inclusion period (HR ¼ 1.50; 95% CI ¼ 1.02-2.40; p ¼ 0.04), the more advanced CDC stage (HR ¼ 2.30; 95% CI ¼ 1.30-3.10; p ¼ 0.000) and the annual frequency of visits > 10 (HR ¼ 2.30; 95% CI ¼ 1.70-3.30; p ¼ 0.000) were associated with an increased risk of depression. Incidence of depression in this HIV cohort was high and the hazard function showed three peaks of depression (2, 7 and 12 years). Physicians should be vigilant to psychological distress throughout life with HIV.

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Section: Discussionsupporting

confidence: 94%

“…10 A total of 2737 subjects were included for a total of 54,706 data records. A single failure Cox proportional hazards model was used to evaluate the adjusted association between failure and explanatory variables.…”

Section: Methodsmentioning

confidence: 99%

Incidence and predictive factors of depression among patients with HIV infection in Guadeloupe: 1988–2009

et al. 2013

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“…Anxiety can be considered a normal emotional response to the reality of living with HIV and this may explain the higher rate of anxiety in the first several months after diagnosis (20). This finding is in line with that of another study that found high rates of depression in relation to duration of infection (6), suggesting that the provision of mental health services at the time of diagnosis could be critical to manage the risk of depression and anxiety among recently-diagnosed individuals.…”

Section: Discussionmentioning

confidence: 99%

“…Prior studies have also noted that most patients in China with anxiety or depression remain untreated and often have a poor understanding of available treatment options (20, 35). This is perhaps not surprising given the chronic and severe undersupply of mental health services in China (36, 37).…”

Section: Discussionmentioning

confidence: 99%

“…Major anxiety and depression frequently go unrecognized and untreated and may foster severe consequences, such as rapid disease progression, suicide, high-risk behaviors and immune system impairment (18–20). In this study, we characterized the prevalence of symptoms of anxiety and depression in Chinese HIV-infected patients, identified risk factors, and sought to assess clinical impacts of anxiety and/or depression on treatment outcomes.…”

Section: Introductionmentioning

confidence: 99%

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The Double Burdens of Mental Health Among AIDS Patients With Fully Successful Immune Restoration: A Cross-Sectional Study of Anxiety and Depression in China

et al. 2018

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Background: Anxiety and depression continue to be significant comorbidities for people with HIV infection. We investigated the prevalence of and factors associated with anxiety and depression among adult HIV-infected patients across China.Methods: In this cross-sectional study, we described clinical and psychosocial variables related to depression and anxiety in 4103 HIV-infected persons. Doctors assessed anxiety and depression by asking patients whether they had experienced anxiety or depression in the prior month. Patients also self-administered the Hospital Anxiety and Depression (HAD) scale; those with score ≥8 on HAD-A/D were considered to be at high risk of anxiety or depression.Results: Associations between socio-demographic, psychosocial, and ART-related clinical factors and risk of depression or anxiety were investigated using multivariable logistic regression. Among patients assessed between 9/2014 and 11/2015, 27.4% had symptoms of anxiety, 32.9% had symptoms of depression, and 19.0% had both. Recentness of HIV diagnoses (P = 0.046) was associated with elevated odds of anxiety. Older age (P = 0.004), higher educational attainment (P < 0.001), employment (P = 0.001), support from family / friends (P < 0.001), and sleep disturbance (P < 0.001), and number of ART regimen switches (P = 0.046) were associated with risk of depression, while neither sex nor transmission route showed any associations. There were no significant associations with HIV-specific clinical factors including current CD4+ T cell count and current viral load.Conclusions: Prevalence of symptoms of anxiety and depression is high in this cohort of treatment-experienced HIV patients. Psychological and social-demographic factors, rather than HIV disease status, were associated with risk of depression and anxiety. This finding highlights the need to deliver interventions to address the mental health issues affecting HIV-infected persons with fully successful immune restoration across China.

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Depression during the COVID‐19 pandemic among people living with HIV: Are low HIV/AIDS stigma and high perceived emotional support protective resources?

Rzeszutek

Gruszczyńska

2023

Stress and Health

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This study has two objectives: first, to examine changes in depressive symptoms among people living with HIV (PLWH) during the COVID‐19 pandemic and, second, to verify the role of HIV/AIDS stigma and perceived emotional support (PES) in the heterogeneity of these changes. The participants were 392 people with a medical diagnosis of HIV who have undergone antiretroviral therapy. Depression was measured at three time points with 6‐month intervals using the Centre for Epidemiological Studies Depression Scale (CES‐D). PES was evaluated with the Berlin Social Support Scales, and HIV/AIDS‐related stigma was assessed with the Berger HIV Stigma Scale. Latent growth class modelling identified four trajectories of depression over the study period: three stable (very high, high, and very low) and one increasing. Both the very high and high stable trajectories had baseline values above the CES‐D cut‐off point for depression, suggesting that 57.6% of the sample was likely to be diagnosed with depression. After controlling for sociodemographic and clinical variables, stigma and PES were found to be significant covariates of the obtained trajectories; however, they did not protect against an increase in depression symptoms. There was no overall increase in depression symptoms among the PLWH participants during the pandemic, but this change in depression symptoms was heterogeneous. We observed the potential development of depression in initially well‐functioning individuals despite their personal resources differing only slightly from those who remained resilient.

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Predictive factors and incidence of anxiety and depression in a cohort of HIV-positive patients in French Guiana

Cited by 32 publications

References 21 publications

Incidence and predictive factors of depression among patients with HIV infection in Guadeloupe: 1988–2009

Incidence and predictive factors of depression among patients with HIV infection in Guadeloupe: 1988–2009

The Double Burdens of Mental Health Among AIDS Patients With Fully Successful Immune Restoration: A Cross-Sectional Study of Anxiety and Depression in China

Depression during the COVID‐19 pandemic among people living with HIV: Are low HIV/AIDS stigma and high perceived emotional support protective resources?

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