Predictive criteria of severe cases in COVID‐19 patients of early stage: A retrospective observational study

Gao, Jinrui; Huang, Xiaofeng; Gu, Haibo; Lou, Lingyun; Xu, Zhihao

doi:10.1002/jcla.23562

Cited by 14 publications

(12 citation statements)

References 36 publications

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“…28 Emerging data indicated that lymphocytopenia was one of the important predictor factors influencing exacerbation and mortality of patients with COVID-19. [29][30][31] Likewise, our data identified that decreased CD4+…”

Section: Control Clarified That Cq Inhibited Viral Replication By Interferingsupporting

confidence: 69%

“…T lymphocyte plays a vital role in SARS‐CoV‐2 elimination by stimulating antigen‐(Ag) specific T lymphocytes 28 . Emerging data indicated that lymphocytopenia was one of the important predictor factors influencing exacerbation and mortality of patients with COVID‐19 29–31 . Likewise, our data identified that decreased CD4+ T cell was a significant risk factor for prolonged viral shedding of the respiratory tract.…”

Section: Discussionmentioning

confidence: 60%

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Risk factors for prolonged virus shedding of respiratory tract and fecal in adults with severe acute respiratory syndrome coronavirus‐2 infection

Zhang

Zhu

et al. 2021

Clinical Laboratory Analysis

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Background The dynamic alteration and comparative study of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) RNA shedding pattern during treatment are limited. This study explores the potential risk factors influencing prolonged viral shedding in COVID‐19. Methods A total of 126 COVID‐19 patients were enrolled in this retrospective longitudinal study. A multivariate logistic regression analysis was carried out to estimate the potential risk factors. Results 38.1% (48/126) cases presented prolonged respiratory tract viral shedding, and 30 (23.8%) cases presented prolonged rectal swab viral shedding. Obesity (OR, 3.31; 95% CI, 1.08–10.09), positive rectal swab (OR, 3.43; 95% CI, 1.53–7.7), treatment by lopinavir/ritonavir with chloroquine phosphate (OR, 2.5; 95% CI, 1.04–6.03), the interval from onset to antiviral treatment more than 7 days (OR, 2.26; 95% CI, 1.04–4.93), lower CD4+ T cell (OR, 0.92; 95% CI, 0.86–0.99) and higher NK cells (OR, 1.11; 95% CI, 1.02–1.20) were significantly associated with prolonged respiratory tract viral shedding. CD3−CD56+ NK cells (OR, 0.87; 95% CI, 0.76–0.99) were related with prolonged fecal shedding. Conclusions Obesity, delayed antiviral treatment, and positive SARS‐CoV‐2 for stool were independent risk factors for prolonged SARS‐CoV‐2 RNA shedding of the respiratory tract. A combination of LPV/r and abidol as the initial antiviral regimen was effective in shortening the duration of viral shedding compared with LPV/r combined with chloroquine phosphate. CD4+ T cell and NK cells were significantly associated with prolonged viral shedding, and further studies are to be warranted to determine the mechanism of immunomodulatory response in virus clearance.

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Section: Control Clarified That Cq Inhibited Viral Replication By Interferingsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 60%

Risk factors for prolonged virus shedding of respiratory tract and fecal in adults with severe acute respiratory syndrome coronavirus‐2 infection

Zhang

Zhu

et al. 2021

Clinical Laboratory Analysis

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“…6 Laboratory findings and chronic comorbidities are important to determine the diagnosis and prognosis of COVID-19. 7,8 The initial tests for COVID-19 patients are complete blood count (CBC), inflammatory and coagulation cascade parameters and other biochemical factors to determine the functionality of vital organs. 9 Vital signs at presentation represent an important indication of severity, used to decide on the therapeutic plan and to monitor patients who are at the risk of developing severe respiratory symptoms.…”

mentioning

confidence: 99%

Prognostic factors for predicting severity and mortality in hospitalized COVID‐19 patients

Aljohani¹,

Khattab²,

Elbadawy

et al. 2022

Clinical Laboratory Analysis

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Background: Coronavirus disease 2019, COVID-19, has reached all the corners of the world and was declared by the WHO as a global pandemic and public health emergency of international concern on the January 31, 2020. Allocating quick and specific biomarkers to predict the disease severity upon admission to hospital became a crucial need. This study, therefore, aimed at exploring the relationship between laboratory results in COVID-19 patients admitted to hospital and the final outcome in these patients. Methods: Retrospective analysis was performed on the medical records of 310 COVID-19-positive patients admitted to Uhod Hospital, the referral hospital in the area of Madinah, Kingdom of Saudi Arabia, between the April 13 and the July 29, 2020. The association of laboratory results with the survival/mortality outcomes was studied. Results: It was demonstrated that lymphopenia, prolonged aPTT, high INR, high D. dimer and high CK are valuable prognostic predictors of the severity of the disease at early stages that can determine the outcome. Based on the results of the multiple logistic regression, the variables that are associated with death outcome are aPTT, HR, RR, ALT and CK level Conclusion: It is proposed to perform these tests on admission to hospital for moderate to severe COVID-19 patients to improve the management of those cases and reduce mortality.

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“…Jinrui et al reported that the higher level of CRP and ALT levels and chronic comorbidities were the risk factors for the progression into severe pneumonia in COVID‐19 patients. 18 Ullah et al defined elevated CRP and D‐dimer levels as independent predictors of in‐hospital mortality. 19 Supporting our results, in a meta‐analysis, age, and CRP levels were also defined as the main risk factors in predicting severe COVID‐19 outcomes.…”

Section: Discussionmentioning

confidence: 99%

Gamma‐glutamyl‐transferase may predict COVID‐19 outcomes in hospitalised patients

Kasapoğlu

Yozgat

Tanoğlu

et al. 2021

Int J Clinical Practice

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Aim In this study, we aimed to define the predictive role of liver function tests at admission to the hospital in outcomes of hospitalised patients with COVID‐19. Material and Method In this multicentric retrospective study, a total of 269 adult patients (≥18 years of age) with confirmed COVID‐19 who were hospitalised for the treatment were enrolled. Demographic features, complete medical history and laboratory findings of the study participants at admission were obtained from the medical records. Patients were grouped regarding their intensive care unit (ICU) requirements during their hospitalisation periods. Results Among all 269 participants, 106 were hospitalised in the ICU and 66 died. The patients hospitalised in ICU were older than patients hospitalised in wards ( P = .001) and expired patients were older than alive patients ( P = .001). Age, elevated serum D‐dimer, creatinine and gamma‐glutamyl transferase (GGT) levels at admission were independent factors predicting ICU hospitalisation and mortality in COVID‐19 patients. Conclusion In conclusion, in hospitalised patients with COVID‐19, laboratory data on admission, including serum, creatinine, GGT and d‐dimer levels have an important predictive role for the ICU requirement and mortality. Since these tests are readily available in all hospitals and inexpensive, some predictive formulas may be calculated with these parameters at admission, to define the patients requiring intensive care.

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Predictive criteria of severe cases in COVID‐19 patients of early stage: A retrospective observational study

Cited by 14 publications

References 36 publications

Risk factors for prolonged virus shedding of respiratory tract and fecal in adults with severe acute respiratory syndrome coronavirus‐2 infection

Risk factors for prolonged virus shedding of respiratory tract and fecal in adults with severe acute respiratory syndrome coronavirus‐2 infection

Prognostic factors for predicting severity and mortality in hospitalized COVID‐19 patients

Gamma‐glutamyl‐transferase may predict COVID‐19 outcomes in hospitalised patients

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