Predictive and prognostic role of mean platelet volume in patients with first-ever acute ischemic stroke

Abstract

Objective:To investigate any possible effects of mean platelet volume (MPV) on short-term stroke prognosis and functional outcome in patients with first-ever acute ischemic stroke (FEAIS).Methods:This retrospective cross-sectional study included 798 FEAIS patients admitted to the emergency department of a tertiary care hospital in Adiyaman, Turkey between January 2013 and June 2015. The data were evaluated according to whether alive or dead, MPV levels, modified Rankin scale (MRS) scores, National Institutes of Health Stroke Scale (NIHSS) scores. The patients were divided into 3 groups based on MPV level as 4.4-7.4 fL, 7.5-10.4 fL, higher than 10.4 fL.Results:A total of 250 patients with FEAIS were included in the study. In both those who survived and those who died, the area under the curve related to hospitalization days, time interval of venipuncture (TIV), and MPV measurements was not statistically significant (p>0.05). The 3 MPV groups showed no significant differences in terms of MRS score, median NIHSS score, hospitalization, and TIV. In subgroups based on MRS scores, there were no statistically significant differences according to median latency (p=0.087), median hospitalization (p=0.394), TIV (p=0.201), and MPV levels (p=0.847). Furthermore, there were no differences in MPV levels between the MRS based groups (p=0.527).Conclusion:The results showed that MPV was not a significantly associated and reliable marker for the prediction of prognosis or functional outcome of FEAIS attack.

Importance of complete blood count parameters and neutrophil-to-lymphocyte ratio in central and peripheral vertigo

“…In a retrospective study by Lok et al (27), who investigated AIS patients, MPV was found to have no predictive or prognostic value. This study also showed similar findings in CV patients, and it was concluded that MPV had no value regarding the differential diagnosis between CV and PV.…”

Mean Platelet Volume Values and Its Effects on Prognosis in Patients with Acute Ischemic Stroke

“…Another study by Nataios et al (16) measured MPV values within the first 24 hours after the onset of stroke and found that MPV levels were not associated with stroke severity and limitation of neurological functions. Further, a retrospective study by Lok et al (17) in 2017 which 798 first time acute ischemic stroke patients participated, showed that MPV values were not associated with short-term stroke prognosis and neurological functions. Also, a study compared MPV values of 281 first-episode acute ischemic stroke and 164 first-episode hemorrhagic stroke patients and found that MPV values were high in both groups but it is not associated with the prognosis (5).…”

A Prospective Study of Role of Mean Platelet Volume, Platelet Distribution Width as Prognostic Markers in Acute Ischemic Stroke Patients

“…Hypertension was the most prevalent risk factor in this study with a percentage of 82. Study conducted by Lok U et al 13 and A. Muscari et al showed hypertension to be the most prevalent risk factor with a percentage of 74 and 84.7 respectively. The other common risk factors were smoking, alcohol, diabetes mellitus and dyslipidaemia.…”