Predictive and Prognostic Factors in Breast Cancer and their Association with ER PR HER2/neu Expression

Sunita, S.; Nath, Jaydeep

doi:10.4172/2157-2518.1000263

Cited by 4 publications

(3 citation statements)

References 17 publications

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“…4 Early diagnosis and appropriate treatment can prolong the survival of patient diagnosed with breast cancer. 5 The number of cancer-related parameters available to predict the prognosis in breast cancer patients has grown considerably in recent years. Prognostic factors of breast cancer include histological features (histological type, histological grade, lymphovascular invasion), tumor size, lymph node status, steroid hormone receptors status and age.…”

Section: Introductionmentioning

confidence: 99%

Role of p53 as a prognostic marker in breast carcinoma and its correlation with tumor size, tumor grade and lymph node metastasis

Jindal¹,

Thakral²,

Mohan³

et al. 2020

IJPO

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Breast cancer is the most frequently diagnosed cancer among females worldwide. p53 tumor suppressor gene regulates the cell cycle and DNA repair and its over-expression in breast cancer is associated with a worse prognosis. This study was done to correlate p53 over-expression with histopathological parameters such as tumor size, tumor grade and lymph node metastasis in breast carcinoma. This retroprospective study was conducted in a tertiary care centre, western U.P. retroprospectively from July 2014 to June 2019. Immuno-histochemical evaluation of 50 histologically confirmed cases of breast carcinoma was done. A total of 50 patients of breast carcinoma were analysed. Most common was Invasive carcinoma of no special type (NST). Most common age group involved was 40-49 years and majority were of age more than 45 years of age. Majority of breast carcinoma cases were of left breast and involving upper outer quadrant. In majority of cases, the tumor size was of more than 2 to 5cms. Majority of cases of breast carcinoma were of grade II according to Nottingham Modified Bloom Richardson System. More than half of patients with lymph nodes showed metastatic deposits. Majority of cases were in moderate prognostic index group. Out of 50 cases, 24(48%) cases showed p53 expression (≥5%). High p53 expression (>50%) was seen in 8(16%) cases of breast carcinoma. A statistically significant association was found between p53 expression, tumor size and lymph node metastasis. No statistically significant association was found between p53 overexpression and tumor grade. Overall, p53 overexpression was found to be poor prognostic factor and its detection may help in risk catergorization and designing future target therapies.

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Section: Introductionmentioning

confidence: 99%

Role of p53 as a prognostic marker in breast carcinoma and its correlation with tumor size, tumor grade and lymph node metastasis

Jindal¹,

Thakral²,

Mohan³

et al. 2020

IJPO

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“…Since various scoring systems were used at different centers of the world for this purpose, the Allred scoring system was introduced for assimilation of these systems (10). Moreover, considering the need for a non-invasive method for evaluating the lymphatic status of patients with breast cancer, and that the Allred scoring system can be measured for all patients with breast cancer (11)(12)(13), and since there is not enough prospective studies on this issue.…”

Section: Introductionmentioning

confidence: 99%

Correlation of Allred Score with Tumor Behavior in Breast Cancer Patients Referred to Shahid-Mohammadi Hospital From 2010 to 2017

Parvar

Abad

Abbasi

et al. 2018

Hormozgan medical journal

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Background: Breast cancer is one of the most common malignancies in women around the world, which makes it essential to identify the behavior of tumors regarding cost-effectiveness and highly diagnostic methods. Objectives: The aim of this study was to determine the relationship between Allred score and tumor behavior in breast cancer patients. Methods: This study was performed on 100 patients with breast cancer. The following data were obtained for each participant: Patient satisfaction and demographic data, tumor size, tumor grade, lymph node involvement and histology of tumor, and Allred score. Chi-square, T student and analysis of variance (ANOVA) tests were used to compare the data. Results: The results of this study showed that Allred score based on PR and ER had a reverse and significant correlation with tumor size (P < 0.05). On the other hand, Allred negative findings were found to be higher in patients with lymph nodes involvement (P < 0.05). Conclusions: Considering the benefits and potentials of Allred score based on PR and ER in detecting tumor behavior and according to the high prevalence of breast cancer, it is suggested for the results of this study to be provided to specialists from different health centers to improve the correct prediction of tumor behavior.

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“…The highest incidence rates of breast cancer are seen in the developed countries (4). Prognostic factors for breast cancer have increased dramatically in recent years, including clinicopathological characteristics, such as tumor size, histologic grade, and axillary lymph node involvement status, which are effective in breast cancer prognosis (5,6). One of the most important factors of determining prognosis in breast cancer recurrence is the lymph node involvement status, the axillary lymph nodes, which receive 75% of breast lymph (7,8).…”

Section: Introductionmentioning

confidence: 99%

Comparing the Detection of Lymph Nodes Micrometastasis in Breast Cancer by the Hematoxylin and Eosin Staining Method (H&E) and the Immunohistochemical Method (IHC)

et al. 2017

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Background: Breast cancer is the most common cancer in women. The most important factor in determining the prognosis and treatment of invasive breast cancer is axillary lymph nodes involvement. It is possible not to detect micrometastasis with applying staining tissues by the Hematoxylin and Eosin (H & E) staining method. Therefore, this study was conducted to determine and compare the detection of axillary lymph node micrometastasis in breast cancer by H & E and immunohistochemical (IHC) method. Methods: A cross sectional analytical study was carried out. By using census method, 80 female patients diagnosed with breast cancer and lymph node non-involvement were selected in Shahid Sadoughi General Hospital pathology ward, Yazd, up to 2016. IHC was performed to re-detect lymph node micrometastasis. The checklist was used to collect data of demographic, clinical, and pathological characteristics of the study population. The data collection was analyzed, using statistical software version SPSS-18, descriptive statistics, and Chi-Square analysis test. P value less than 0.05 was considered statistically significant. Results: Of the 80 samples using H & E staining method, no case was diagnosed with lymph node micrometastasis, but using IHC, 50 cases (62.5%) were found negative and 30 cases (37.5%) were found positive. The majority of tumors in the positive group had poorly differentiated grade and the difference between the tumor grade in both positive and negative group was statistically significant (P = 0.001). Also, the majority of tumors in the positive group were located in the upper-outer and lower-outer quadrant of breast and the difference between tumor locations in both positive and negative group was statistically significant (P = 0.001). Conclusions: According to the results, IHC is more beneficial than the H&E method to detect micrometastatic cells and to examine tissues that have high-grade tumors and also tumors located in upper-outer or lower-outer more possibility of metastasis.

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Predictive and Prognostic Factors in Breast Cancer and their Association with ER PR HER2/neu Expression

Cited by 4 publications

References 17 publications

Role of p53 as a prognostic marker in breast carcinoma and its correlation with tumor size, tumor grade and lymph node metastasis

Role of p53 as a prognostic marker in breast carcinoma and its correlation with tumor size, tumor grade and lymph node metastasis

Correlation of Allred Score with Tumor Behavior in Breast Cancer Patients Referred to Shahid-Mohammadi Hospital From 2010 to 2017

Comparing the Detection of Lymph Nodes Micrometastasis in Breast Cancer by the Hematoxylin and Eosin Staining Method (H&E) and the Immunohistochemical Method (IHC)

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