Prediction of tolerance on the basis of quantification of egg white-specific IgE antibodies in children with egg allergy

Boyano-Martínez, Teresa; García-Ara, Carmen; Díaz-Pena, José María; Martín-Esteban, Manuel

doi:10.1067/mai.2002.126081

Cited by 290 publications

(226 citation statements)

References 9 publications

Supporting

Mentioning

200

Contrasting

Unclassified

Order By: Relevance

“…114 Further studies with crude allergen extracts mostly verified a general trend of a correlation between high sIgE titers and slow outgrowth of cow's milk or hen's egg allergy. [115], [116], [117], [118] and [119] Yet again a significant overlap in serum sIgE reactivity of patients with early and late outgrowth was apparent. However, systematic studies with recombinant food allergens as sensitivity-improved test agents in quantitative sIgE determinations are still lacking.…”

Section: Quantification Of Ige Antibodiesmentioning

confidence: 99%

Potential, pitfalls, and prospects of food allergy diagnostics with recombinant allergens or synthetic sequential epitopes

Steckelbroeck¹,

Ballmer‐Weber²,

Vieths³

2008

Journal of Allergy and Clinical Immunology

View full text Add to dashboard Cite

This article aims to critically review developments in food allergy diagnostics with regard to the verification of specific IgE antibodies and the identification of the responsible allergens. Results of IgE-binding tests with food extracts are hampered by cross-reactive proteins, low-quality test agents, or both. Specificity can be increased by defining adequate cutoff values, whereas sensitivity can be improved by using high-quality test agents. IgE-binding tests with purified allergens enabled reliable quantification of allergen-specific IgE titers, with higher levels found in individuals with food allergy compared with individuals without food allergy. However, the overlap in individual test reactivity between allergic and nonallergic subjects complicates interpretation. Recombinant allergens and synthetic sequential epitopes enabled detection of sensitization profiles, with IgE specific to several allergens and substructures now being suggested as markers of severity, persistence, or both. However, high-power quantitative studies with larger numbers of patients are required to confirm these markers. This article aims to critically review developments in food allergy diagnostics with regard to the verification of specific IgE antibodies and the identification of the responsible allergens. Results of IgE-binding tests with food extracts are hampered by cross-reactive proteins, low-quality test agents, or both. Specificity can be increased by defining adequate cutoff values, whereas sensitivity can be improved by using high-quality test agents. IgE-binding tests with purified allergens enabled reliable quantification of allergen-specific IgE titers, with higher levels found in individuals with food allergy compared with individuals without food allergy. However, the overlap in individual test reactivity between allergic and nonallergic subjects complicates interpretation. Recombinant allergens and synthetic sequential epitopes enabled detection of sensitization profiles, with IgE specific to several allergens and substructures now being suggested as markers of severity, persistence, or both.However, high-power quantitative studies with larger numbers of patients are required to confirm these markers. IgE-mediated and non-IgE-mediated syndromes, where IgE-mediated manifestations are responsible for the majority of food-induced, immediate-type, immune-mediated hypersensitivity reactions. 3 The development of an IgE-mediated response to food requires a series of molecular and cellular interactions, which involve antigenpresenting cells, T lymphocytes, and B lymphocytes. [4] and [5] Depending on the route of sensitization, food allergy is the result of either genuine reactivity to comestibles through the gastrointestinal tract (class I food allergens) or secondary sensitization to cross-reactive food allergens as a consequence of the initial reactivity to homologous pollen-related allergens (class II food allergens). [6] and [7] The majority of class I food allergens are heat stable and resistan...

show abstract

Section: Quantification Of Ige Antibodiesmentioning

confidence: 99%

Potential, pitfalls, and prospects of food allergy diagnostics with recombinant allergens or synthetic sequential epitopes

Steckelbroeck¹,

Ballmer‐Weber²,

Vieths³

2008

Journal of Allergy and Clinical Immunology

View full text Add to dashboard Cite

show abstract

“…With regard to the dietary environment on AD, numerous publications have exclusively focused on the elimination of food antigens such as cow's milk or eggs (Boyano-Martinez et al, 2002;Mattila et al, 2003;Oranje et al, 2002;Sicherer and Sampson, 1999). Alternatively, we conducted a treatment consisting of an energy-restricted diet for patients with AD, and reported that body weight loss by energy restriction was positively associated with improvement of AD (Kouda et al, 2000;Tanaka et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

An Adult with Atopic Dermatitis and Repeated Short-term Fasting

Nakamura¹,

Shimoji

Kouda³

et al. 2003

J. Physiol. Anthropol.

View full text Add to dashboard Cite

It has been reported that nutritional stress, such as short-term fasting and long-term energy restriction, has a suppressive effect on allergic dermatitis in experimental animals. Furthermore, clinical study has demonstrated a positive association between weight loss by low-energy diet and improvement in patients with atopic dermatitis. In this report, a 23-year-old female with atopic dermatitis received a treatment of repeated short-term fasting. 24-hour fasting was conducted once a week for a period of 20 weeks. On the fasting day, the amount of energy intake was 200 kcal. No medication was administered during the trial period. Clinical symptoms were evaluated using the Scoring Atopic Dermatitis index, and IgE, lactase dehydrogenase-5, and number of eosinophils were measured. At the end of the trial, body weight was reduced and clinical symptoms improved, whereas no improvements in laboratory findings were shown. For sufficient evidence of the effects of fasting, additional controlled study is needed.

show abstract

“…Se estima que entre 30 y 50 % de los menores de 5 años adquieren tolerancia al huevo entre los 5 y los 10 años, especialmente si la afectación es solo cutánea (14,59). Por ello se recomienda evaluar la sensibilidad mediante la determinación de IgE específica y la prueba intraepidérmica cada año y, si parece que se ha adquirido tolerancia, esta debe probarse mediante una prueba de provocación vigilada.…”

Section: Manejounclassified

Alergia a la leche y al huevo: diagnóstico, manejo e implicaciones en América Latina

Sánchez¹,

Restrepo

Mopan

et al. 2013

biomedica

View full text Add to dashboard Cite

La sensibilización a alimentos y el desarrollo de alergias alimentarias viene aumentando en todo el mundo, siendo la leche de vaca y el huevo de gallina los principales alimentos implicados. En la mayoría de los países latinoamericanos no existen guías de manejo y cuando se elaboren deberán adaptarse a las condiciones de la población de cada región. En el presente artículo presentamos una revisión del manejo de la alergia alimentaria a la leche y al huevo útil para el personal de salud de todos los niveles, así como algunas consideraciones de los factores presentes en los países latinoamericanos.Palabras clave: alergia e inmunología, hipersensibilidad al huevo, hipersensibilidad a la leche, alimentos, anafilaxia, dieta, desensibilización inmunológica, inmunoterapia, tolerancia. doi: http://dx.doi.org/10.7705/biomedica.v34i1.1677 Milk and egg allergy: Diagnosis, management and implications for Latin AmericaSensitization to food allergens, as well as the development of food allergies, is increasing worldwide, and cow's milk and hen's eggs are the main implicated foods. In most Latin American countries there are no management guidelines on the aforementioned topics; at their creation, such guidelines should be adapted to the conditions of the population in each region. This paper presents a review of the management of food allergy to milk and eggs useful for health personnel at all levels and some considerations of the factors found in Latin American developing countries.Keywords: Allergy and immunology, egg hypersensitivity, milk hypersensitivity, food, anaphylaxis, diet; desensitization, immunologic; immunotherapy, permissiveness. doi: http://dx.doi.org/10. 7705/biomedica.v34i1.1677 Las reacciones adversas a los alimentos se producen por una gran variedad de mecanismos que incluyen el sistema inmunitario, los procesos enzimáticos, las reacciones fisiológicas y los componentes psicológicos (1). Cuando se demuestra un mecanismo inmune, se le denomina alergia a alimentos, y si se encuentran niveles elevados de inmunoglobulina E (IgE) específica para alérgenos de alimentos con relevancia clínica, se habla de alergia alimentaria mediada por IgE (2). Igualmente, se pueden presentar reacciones alérgicas a alimentos mediadas por mecanismos celulares y alergias alimentarias mixtas, en las cuales participan los dos mecanismos anteriores.Los alimentos implicados y la frecuencia de las reacciones dependen de los hábitos y costumbres alimentarias en los distintos países, al igual que de los parámetros metodológicos utilizados en los diferentes estudios. Se estima que la prevalencia de reacciones adversas a alimentos es de entre 13 y 43 %, según informes de los padres de niños preescolares (3,4); sin embargo, solo una parte de las reacciones reportadas en dichos informes se deben realmente a un alimento; en un estudio en el que 28 % de los pacientes había

show abstract

Prediction of tolerance on the basis of quantification of egg white-specific IgE antibodies in children with egg allergy

Cited by 290 publications

References 9 publications

Potential, pitfalls, and prospects of food allergy diagnostics with recombinant allergens or synthetic sequential epitopes

Potential, pitfalls, and prospects of food allergy diagnostics with recombinant allergens or synthetic sequential epitopes

An Adult with Atopic Dermatitis and Repeated Short-term Fasting

Alergia a la leche y al huevo: diagnóstico, manejo e implicaciones en América Latina

Contact Info

Product

Resources

About