An Adult with Atopic Dermatitis and Repeated Short-term Fasting

Nakamura, Harunobu; Shimoji, K; Kouda, Katsuyasu; Tokunaga, Rikio; Takeuchi, Hisanao

doi:10.2114/jpa.22.237

Cited by 13 publications

(11 citation statements)

References 22 publications

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“…In fact, decrease in cholesterol by fasting improved skin symptoms in AD patients (Kimata, 2002). Moreover, decrease in cholesterol by vegetarian diet or short-term fasting improved skin symptoms of AD (Nakamura et al, 2003;Tanaka et al, 2001).…”

Section: Discussionmentioning

confidence: 95%

Cholesterol selectively enhances in vitro latex-specific IgE production in atopic dermatitis patients with latex allergy

Kimata

2005

Life Sciences

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Section: Discussionmentioning

confidence: 95%

Cholesterol selectively enhances in vitro latex-specific IgE production in atopic dermatitis patients with latex allergy

Kimata

2005

Life Sciences

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“…In a clinical study, a low-energy diet reduced inflammatory symptoms and oxidative damage in patients with atopic dermatitis (Kouda et al, 2000). A case of a patient with atopic dermatitis and repeated one day fasting has also been reported (Nakamura et al, 2003). Furthermore, rapid and sustained beneficial effects of alternate-day calorie restriction in overweight adults with asthma have been recently reported (Johnson et al, 2007).…”

mentioning

confidence: 99%

Beneficial Effects of Mild Stress (Hormetic Effects): Dietary Restriction and Health

Kouda

Iki

2010

J Physiol Anthropol

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Hormesis is defined as a dose-response phenomenon characterized by low-dose stimulation and highdose inhibition, and has been recognized as representing an overcompensation for mild environmental stress. The beneficial effects of mild stress on aging and longevity have been studied for many years. In experimental animals, mild dietary stress (dietary restriction, DR) without malnutrition delays most age-related physiological changes, and extends maximum and average lifespan. Animal studies have also demonstrated that DR can prevent or lessen the severity of cancer, stroke, coronary heart disease, autoimmune disease, allergy, Parkinson's disease and Alzheimer's disease. The effects of DR are considered to result from hormetic mechanisms. These effects were reported by means of various DR regimens, such as caloric restriction, total-nutrient restriction, alternate-day fasting, and short-term fasting. Mild dietary stress, including restriction of amount or frequency of intake, is the essence of DR. For more than 99% of their history, humans lived as hunter-gatherers and adapted to restrictions in their food supply. On the other hand, an oversufficiency of food for many today has resulted in the current global epidemic of obesity and obesity-related diseases. DR may be used, therefore, as a novel approach for therapeutic intervention in several diseases, when detailed information about effects of mild dietary stress on human health is obtained from clinical trials. J Physiol Anthropol 29(4): [127][128][129][130][131][132] 2010 Dietary Restriction (DR) and HormesisThe hormetic dose-response model is the most common and fundamental in the biological and biomedical sciences (Calabrese, 2008b). Hormesis is defined as a dose-response phenomenon characterized by low-dose stimulation and highdose inhibition. This dose-response curve typically appears as an inverted U-shape or J-shape (Calabrese, 2008ab). Hormesis represents an overcompensation for mild environmental stress (Calabrese, 2001) and is the mechanism for adaptive responses to low doses of harmful environmental stimuli (Calabrese, 2008a). These harmful conditions include not only toxic substances, but also any environmental stimulus with potentially deleterious consequences for the organism, such as an increase or decrease in temperature. A stimulus that induces a beneficial hormetic response is called a mild stress (Le Bourg, 2009). Mild stress appears to slightly increase lifespan and to increase resistance to some stresses (Le Bourg, 2009).Mild dietary stress (dietary restriction, DR) without malnutrition delays most age-related physiological changes and extends maximum and average lifespan in experimental animals (Weindruch and Sohal, 1997; Frame et al., 1998). The first evidence in rodents was reported by McCay et al. in 1935(McCay et al., 1935. Since then, similar observations have been made in various species, including fish (Comfort, 1963), flies (Partridge et al., 1987), worms (Klass, 1977, and yeast (Lin et al., 2000). More recently, DR wa...

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“…Some authors reported the effects of low calory diets in adult AD. According to the results of Nakamura et al [21] and Tanaka et al [22] low calory diet resulted the improvement of skin symptoms: itching, and the sleep disturbance becoming milder. A significant decrease of the SCORAD index, LDH5 activity, eosinophil number, peripherial NK activity and neutrofil number and PGE2 synthesis of monocytes was shown.…”

Section: Discussionmentioning

confidence: 96%

Is the alternative medicine a real alternative in adult atopic dermatitis? Experiences of 125 patients

Pónyai¹,

Temesvári²,

Kárpáti³

2016

Glob Dermatol

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An Adult with Atopic Dermatitis and Repeated Short-term Fasting

Cited by 13 publications

References 22 publications

Cholesterol selectively enhances in vitro latex-specific IgE production in atopic dermatitis patients with latex allergy

Cholesterol selectively enhances in vitro latex-specific IgE production in atopic dermatitis patients with latex allergy

Beneficial Effects of Mild Stress (Hormetic Effects): Dietary Restriction and Health

Is the alternative medicine a real alternative in adult atopic dermatitis? Experiences of 125 patients

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