Prediction of prognosis in breast cancer patients based on neutrophil to lymphocyte ratio in a tertiary centre

Abstract

In recent decade there has been a substantial increase in breast cancer both in developed and developing countries. It's also has been the major cause of mortality in women, despite much progress in treatment for breast cancer. There is always a debate in assessment of prognosis in breast cancer. Inflammation play a major role in pathogenesis of breast cancer based of the cell type. Neutrophil-to-lymphocyte ratio is a simple parameter which helps in predicting the prognosis of the patient. In this study, we would like to analyse peripheral blood neutrophil-lymphocyte ratio (NLR) in breast cancer patients and its correlation with disease staging. This cross-sectional study was conducted in R.L Jalappa hospital. A total of 30 female patients with breast cancer met the inclusion criteria. Exclusion criteria included clinical evidence of active infection, presence of haematological disorders, acute as well as chronic inflammatory or autoimmune diseases, or prior steroid therapy. There was no association between the tumour size and age of patients with NLR. There was a significant relationship between NLR and staging of the disease.