Prediction of physical properties of yeast cell suspensions using dielectric spectroscopy

Currie, David J.; Lee, M.H.; Todd, Richard W.

doi:10.1109/ceidp.2006.312021

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Physical Modeling Of Dielectric Properties Of Cell Suspensions1

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2008

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“…The physical modeling algorithm predicts cell size and concentration using a three-stage approach [33]. In the first step, the Cole-Cole equation is fitted to experimental permittivity data [34].…”

Section: Physical Modeling Of Dielectric Properties Of Cell Suspensionsmentioning

confidence: 99%

Cole–Cole, linear and multivariate modeling of capacitance data for on-line monitoring of biomass

Dabros

Dennewald

Currie

et al. 2008

Bioprocess Biosyst Eng

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This work evaluates three techniques of calibrating capacitance (dielectric) spectrometers used for on-line monitoring of biomass: modeling of cell properties using the theoretical Cole-Cole equation, linear regression of dual-frequency capacitance measurements on biomass concentration, and multivariate (PLS) modeling of scanning dielectric spectra. The performance and robustness of each technique is assessed during a sequence of validation batches in two experimental settings of differing signal noise. In more noisy conditions, the Cole-Cole model had significantly higher biomass concentration prediction errors than the linear and multivariate models. The PLS model was the most robust in handling signal noise. In less noisy conditions, the three models performed similarly. Estimates of the mean cell size were done additionally using the Cole-Cole and PLS models, the latter technique giving more satisfactory results.

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Section: Physical Modeling Of Dielectric Properties Of Cell Suspensionsmentioning

confidence: 99%

Cole–Cole, linear and multivariate modeling of capacitance data for on-line monitoring of biomass

Dabros

Dennewald

Currie

et al. 2008

Bioprocess Biosyst Eng

View full text Add to dashboard Cite

show abstract

Prediction of physical properties of yeast cell suspensions using dielectric spectroscopy

Cited by 1 publication

References 5 publications

Cole–Cole, linear and multivariate modeling of capacitance data for on-line monitoring of biomass

Cole–Cole, linear and multivariate modeling of capacitance data for on-line monitoring of biomass

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