Prediction of metabolic syndrome in women with polycystic ovary syndrome

Abstract

Objective: To identify biochemical factors that serve as predictors for the metabolic syndrome (MetS) in patients with polycystic ovary syndrome (PCOS) and to investigate the value of adipocytokines in the prediction of metabolic syndrome. Material and Methods:A total of 91 pre-menopausal women with PCOS diagnosed according to the Rotterdam consensus criteria were recruited as study subjects. Waist circumference, blood pressure, body mass index (BMI), fasting glucose, serum lipids, insulin, FSH, LH, E 2 , total testosteron, homeostatic model assessment-insulin resistance (HOMA-IR), serum leptin and adiponectin levels were evaluated for all patients. Results:Of the 91 women with PCOS, 15 patients met the criteria for MetS. Body weight, BMI, waist circumference, systolic blood pressure, diastolic blood pressure, fasting glucose, total cholesterol, triglyceride, and VLDL concentrations were significantly higher and HDL was significantly lower in women with PCOS+MetS compared with those with PCOS only. However, the level of LDL, FSH, LH, E 2 and total testesterone was not significantly different between these two groups. Women with PCOS+MetS had significantly higher levels of leptin and HOMA-IR, and significantly lower levels of adiponectin compared to the women with PCOS only. In the multiple logistic regression model, the association between HOMA-IR and leptin, and MetS remained statistically significant (p=0.001 and 0.018), while the association between adiponectin and MetS was no longer statistically significant. Conclusion: Abstract ÖzetOriginal Investigation 178

Alarin: A new predictive marker in infertile women with polycystic ovary syndrome: A case–control study

“…In numerous published studies, authors identified various markers for predicting PCOS risk, including coagulation parameters, sex-hormone binding globulin, irisin, betatrophin, zinc-alpha-glycoprotein, and leptin. 27,28 To the best of our knowledge, our study is the first to evaluate the relationship between alarin and PCOS status in women with infertility. Our study differs from other studies by evaluating infertile controls and PCOS group with infertility.…”

What do we know about metabolic syndrome in adolescents with PCOS?

“…They found ghrelin levels to be lower in women with PCOS and also lower still in patients with hyperandrogenaemia. Ersan et al (29) investigated the relationship between adipocytokines and metabolic syndrome in pre-menopausal women with PCOS; adiponectin was found to be significantly lower and leptin was significantly higher in patients with PCOS and metabolic syndrome. However, in a recent study, the levels of metabolic risk markers like adiponectin, leptin and ghrelin were measured in obese adolescents with and without PCOS; all were found to be similar in both groups (30).…”

Visceral adiposity index: Simple Tool for assessing cardiometabolic risk in women with polycystic ovary syndrome

“…[2] In various studies, this increased cardiometabolic risk has been mainly attributed to increased visceral fat as visceral fat is the main source of free fatty acids and inflammatory cytokines. [23456] About 50–60% of women with PCOS have central body fat distribution. [3] Thus, in women with PCOS assessing visceral adipose dysfunction at a younger age should help in preventing the future cardiometabolic complications by either lifestyle modification or medical treatment.…”