Alarin: A new predictive marker in infertile women with polycystic ovary syndrome: A case–control study

Görkem, Ümit; Yıldırım, Engin

doi:10.1111/jog.15176

Cited by 3 publications

(10 citation statements)

References 28 publications

(56 reference statements)

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“…It has also been reported that patients with MetS have significantly higher blood alarin levels than healthy subjects (45). This is further supported by another human study, which indicates that blood alarin levels are higher in women with MetS than controls (61). Alarin was shown to have a positive correlation with fasting blood glucose (FBG), body mass index (BMI), waist circumference, blood pressure, triglyceride, total cholesterol, glycosylated hemoglobin (HbA1c), homeostasis model assessment of b-cell function (HOMA-b), and HOMA of IR (HOMA-IR) in patients with MetS (45).…”

Section: Obesity and Metabolic Syndromesupporting

confidence: 72%

“…Alarin was shown to have a positive correlation with fasting blood glucose (FBG), body mass index (BMI), waist circumference, blood pressure, triglyceride, total cholesterol, glycosylated hemoglobin (HbA1c), homeostasis model assessment of β-cell function (HOMA-β), and HOMA of IR (HOMA-IR) in patients with MetS ( 45 ). Other studies have also found positive correlations between serum levels of alarin and BMI, waist circumference, blood pressure, triglyceride, FBG, HbA1c, fasting insulin, and HOMA-IR ( 58 , 61 ). Furthermore, alarin was identified as an independent predictor of the risk factors of MetS, including central obesity, IR, dyslipidemia, hyperglycemia, and hypertension ( 45 ).…”

Section: Role Of Alarin In Various Disease Conditionsmentioning

confidence: 91%

“…The Turkish study was the first to confirm the association between serum alarin levels and different ovarian reserve patterns, including PCOS. There was a higher serum alarin concentration in the infertile women with PCOS and a positive correlation between serum alarin and LH level only in the PCOS women rather than other unexplained infertility (48,61). Elevated levels of alarin is positively correlated with increased serum LH levels in women with PCOS.…”

Section: Polycystic Ovarian Syndromementioning

confidence: 92%

“…In addition, alarin has recently been discovered to be implicated in the pathogenesis of hypertension (11,61). Numerous studies have reported the positive relationship between circulating alarin levels and blood pressure (45, 52,57,58,61). Alarin has been found to increase levels of superoxide anions and NADPH oxidase activity in the hypothalamic PVN that modulates sympathetic activity and blood pressure and results in abnormal blood pressure or hypertension (68)(69)(70)(71)(72)(73).…”

Section: Hypertensionmentioning

confidence: 99%

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The evolving roles of alarin in physiological and disease conditions, and its future potential clinical implications

Abebe

Mengstie²,

Seid³

et al. 2022

Front. Endocrinol.

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Alarin is a member of the galanin family of neuropeptides that is widely expressed in the central nervous system and peripheral tissues in humans and rodents. It was initially isolated fifteen years ago in ganglionic cells of human neuroblastoma. Subsequently, it was demonstrated to be broadly distributed in the blood vessels, skin, eyes, peripheral and central nervous systems, thymus, gastrointestinal tract, and endocrine organs of different species. Alarin is a 25 amino acid neuropeptide derived from the alternative splicing of the GALP gene, missing exon 3. It is found to be involved in several physiological functions that include feeding behavior, energy homeostasis, glucose homeostasis, body temperature, and reproduction. It has also vasoactive, anti-inflammatory, anti-edema, and antimicrobial activities. However, the physiological effects of alarin have not been fully elucidated and the receptors that mediate these effects are not currently known. Unearthing the novel biological effects of alarin and its unidentified receptors will therefore be a task in future biomedical research.In addition, alarin is involved in various disease conditions, such as metabolic syndrome, obesity, insulin resistance, type 2 diabetes, diabetic retinopathy, hypertension, cardiac fibrosis, polycystic ovarian syndrome, and depression. Thus, alarin may serve as a promising tool for future pharmacological treatment and diagnosis. But further research is awaited to confirm whether alarin has a protective or pathological role in these diseases. This article provides a comprehensive review on the evolving implications of alarin in a variety of physiological and disease conditions, and its future perspectives.

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Section: Obesity and Metabolic Syndromesupporting

confidence: 72%

Section: Role Of Alarin In Various Disease Conditionsmentioning

confidence: 91%

Section: Polycystic Ovarian Syndromementioning

confidence: 92%

Section: Hypertensionmentioning

confidence: 99%

See 2 more Smart Citations

The evolving roles of alarin in physiological and disease conditions, and its future potential clinical implications

Abebe

Mengstie²,

Seid³

et al. 2022

Front. Endocrinol.

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show abstract

“…Elevated circulating alarin level, associating with increased LH concentration, was found in infertile women with poor ovarian reserve patterns [ 36 ]. Further research by this team confirmed a higher serum alarin concentration in the infertile women diagnosed with polycystic ovary syndrome (PCOS) and a positive correlation between serum alarin and LH level only in the PCOS women rather than other unexplained infertile [ 37 ]. To our knowledge, this is the first study to evaluate the relationship between serum alarin levels and the risk of CVD.…”

Section: Discussionmentioning

confidence: 99%

Serum Tenascin-C and Alarin Levels Are Associated with Cardiovascular Diseases in Type 2 Diabetes Mellitus

Zhu

et al. 2022

International Journal of Endocrinology

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Background. Tenascin-C (TNC), an extracellular matrix glycoprotein, is elevated in inflammatory and cardiovascular pathologies, whereas alarin, a novel orexigenic peptide, participates in insulin resistance and glycometabolism. The roles of these molecules in individuals with cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM), clinical conditions associating with metabolic disorders, and chronic inflammation, remain controversial. Our study aimed at determining the potential role of TNC and alarin in CVD adult patients with T2DM. Methods. This was a cross-sectional study. Basic and clinical information for 250 patients with T2DM were analyzed. Based on their cardiovascular disease status, participants were assigned into the CVD and non-CVD groups. Serum TNC and alarin levels were assessed by enzyme-linked immunosorbent assay (ELISA). Results. Serum TNC and alarin concentrations in the CVD group were significantly higher than those of the non-CVD group. Moreover, serum TNC levels were positively correlated with age, waist circumference, and waist-hip ratio; however, they were negatively correlated with TC, LDL-C, and eGFR levels. Alarin levels were positively correlated with BMI, waist circumference, and hip circumference. In logistic regression models, TNC and alarin were also established to be independent determinants for CVD in T2DM patients and their increases were associated with CVD severity. Receiver operating characteristic (ROC) curve analysis showed that the area under curve (AUC) values for TNC and alarin were 0.68 and 0.67, respectively. TNC and alarin were good predictors of CVD occurrence. When the cutoff value for TNC was 134.05 pg/mL, its sensitivity was 69.47% while its specificity was 61.29%. When the cutoff value for alarin was 142.69 pg/mL, sensitivity and specificity were 38.95% and 90.97%, respectively. Conclusion. Elevated TNC and alarin levels are independently associated with the occurrence and severity of CVD in T2DM individuals. Therefore, these two biomarkers are potential diagnostic and prognostic indicators for CVD in diabetics.

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Neuroendocrine features of the pathogenesis of polycystic ovary syndrome (literature review)

Absatarova,

Evseeva,

Andreeva

2023

Probl Endokrinol (Mosk)

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Polycystic ovary syndrome (PCOS) is one of the most pressing problems in endocrine gynecology. The main signs of the disease are hyperandrogenism, menstrual and/or ovulatory dysfunction, and polycystic ovarian structure according to ultrasound. Women with PCOS are at risk for developing metabolic syndrome, type 2 diabetes, cardiovascular disease, and endometrial cancer. In this connection, the pathogenetic mechanisms of the occurrence of this syndrome are continuously studied and new methods of treatment are being sought. PCOS is characterized by a wide range of various disorders of the neuroendocrine regulation of the reproductive system. The main focus of the review is aimed at summarizing information about the etiological role of neuropeptides and neurotransmitters, such as phoenixin, galanins, orexins, GABA, in the pathophysiology of PCOS and about the possibility of their use for diagnostic and therapeutic purposes. In recent decades, the interest of scientists has been focused on the study of KNDy neurons, because it is the kisspeptin synthesized by them that is one of the main regulators of the hypothalamic-pituitary-ovarian axis. This article discusses data on the significance of KNDy neurons in the pathogenesis of the syndrome. Information is provided on the effect of elevated levels of androgens and anti-Müllerian hormone on GnRH neurons. Also analyzed are studies on functional and structural disorders in the hypothalamus in PCOS. Literature search was carried out in national (eLibrary, CyberLeninka.ru) and international (PubMed, Cochrane Library) databases in Russian and English. The priority was free access to the full text of articles. The choice of sources was prioritized for the period from 2018 to 2023.However, taking into account the insufficient knowledge of the chosen topic, the choice of sources dates back to 1998.

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Alarin: A new predictive marker in infertile women with polycystic ovary syndrome: A case–control study

Cited by 3 publications

References 28 publications

The evolving roles of alarin in physiological and disease conditions, and its future potential clinical implications

The evolving roles of alarin in physiological and disease conditions, and its future potential clinical implications

Serum Tenascin-C and Alarin Levels Are Associated with Cardiovascular Diseases in Type 2 Diabetes Mellitus

Neuroendocrine features of the pathogenesis of polycystic ovary syndrome (literature review)

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