Prediction of lymph node status in patients with superficial esophageal carcinoma: analysis of 160 surgically resected cancers

Shimada, Hideaki; Nabeya, Yoshihiro; Matsubara, Hisahiro; Okazumi, Shinichi; Shiratori, Tooru; Shimizu, Takanori; Aoki, Taito; Shuto, Kiyohiko; Akutsu, Yasunori; Ochiai, Takenori

doi:10.1016/j.amjsurg.2005.07.035

Cited by 130 publications

(115 citation statements)

References 17 publications

Supporting

Mentioning

100

Contrasting

Unclassified

Order By: Relevance

“…A number of retrospective studies involving histopathological analyses of surgically resected specimens of esophageal squamous cell carcinomas (SCCs) have shown that cases of non-invasive epithelial carcinoma (EP, carcinoma in situ) and intra-mucosal invasive carcinoma limited to the lamina propria mucosae (LPM) had an extremely low risk of lymph node and dis-tant metastasis [1][2][3][4][5][6][7] . Based on these findings, the Japanese guidelines state that the indication for ER of esophageal SCC is a lesion limited to EP or LPM.…”

Section: Introductionmentioning

confidence: 99%

Endoscopic submucosal dissection for superficial esophageal squamous cell neoplasms

Honda

Akiho

2012

WJGP

View full text Add to dashboard Cite

Endoscopic resection is an effective treatment for noninvasive esophageal squamous cell neoplasms (ESCNs). Endoscopic mucosal resection (EMR) has been developed for small localized ESCNs as an alternative to surgical therapy because it shows similar effectiveness and is less invasive than esophagectomy. However, EMR is limited in resection size and therefore piecemeal resection is performed for large lesions, resulting in an imprecise histological evaluation and a high frequency of local recurrence. Endoscopic submucosal dissection (ESD) has been developed in Japan as one of the standard endoscopic resection techniques for ESCNs. ESD enables esophageal lesions, regardless of their size, to be removed en bloc and thus has a lower local recurrence rate than EMR. The development of new devices and the establishment of optimal strategies for esophageal ESD have resulted in fewer complications such as perforation than expected. However, esophageal stricture after ESD may occur when the resected area is larger than three-quarters of the esophageal lumen or particularly when it encompasses the entire circumference; such a stricture requires multiple sessions of endoscopic balloon dilatation.Recently, oral prednisolone has been reported to be useful in preventing post-ESD stricture. In addition, a combination of chemoradiotherapy (CRT) and ESD might be an alternative therapy for submucosal esophageal cancer that has a risk of lymph node metastasis because esophagectomy is extremely invasive; CRT has a higher local recurrence rate than esophagectomy but is less invasive. ESD is likely to play a central role in the treatment of superficial esophageal squamous cell neoplasms in the future.

show abstract

Section: Introductionmentioning

confidence: 99%

Endoscopic submucosal dissection for superficial esophageal squamous cell neoplasms

Honda

Akiho

2012

WJGP

View full text Add to dashboard Cite

show abstract

“…the muscularis mucosa; sm1, tumors invading the most superficial 1/3 of the submucosa; sm2/3, tumors invading deeper than sm1 level) (16,(18)(19)(20)(21)(22). Eguchi et al (21) demonstrated that lymph node metastasis was found in 0, 6, 18, 53 and 54% of m1, m2, m3, sm1 and sm2/3 lesions, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…Eguchi et al (21) demonstrated that lymph node metastasis was found in 0, 6, 18, 53 and 54% of m1, m2, m3, sm1 and sm2/3 lesions, respectively. Shimada et al (22) demonstrated that it was found in 0, 0, 6, 32 and 39% of each type of lesion, respectively. Furthermore, several biological markers predicting lymph node metastasis of ESCC have been identified.…”

Section: Discussionmentioning

confidence: 99%

p12CDK2-AP1 is associated with tumor progression and a poor prognosis in esophageal squamous cell carcinoma

Hiyoshi

Watanabe²,

Hirashima³

et al. 2009

Oncol Rep

View full text Add to dashboard Cite

Abstract. p12 CDK2-associating protein 1 (p12 CDK2-AP1 ) is a growth suppressor that negatively regulates cyclin-dependent kinase 2 (CDK2) activities. In addition, p12CDK2-AP1 has also been shown to interfere in DNA replication. A reduction of p12 CDK2-AP1 expression is known to be a negative prognostic indicator in patients with oral squamous cell carcinoma. To elucidate the role of p12 CDK2-AP1 expression in esophageal squamous cell carcinoma (ESCC), we immunohistochemically examined the expression of p12 CDK2-AP1 protein in 120 resected ESCC specimens and determined its association with the clinicopathological characteristics and prognosis. Of the 120 ESCCs, 79 (65.8%) showed positive staining (≥25% of cancer cells showing p12 CDK2-AP1 expression), while 41 (34.2%) lacked the staining (<25% of cancer cells showing p12 CDK2-AP1 expression). Negative staining for p12 CDK2-AP1 was found to be significantly associated with advanced lesions [depth of tumor (P=0.001), lymph node metastasis (P<0.001), pathological stage (P<0.0001) and venous invasion (P<0.0001)], and a poor prognosis (disease-free survival and overall survival: log-rank P<0.05). The rate of lymph node metastasis in patients with p12 CDK2-AP1 negative-T1 ESCC was significantly higher than that in patients with p12 CDK2-AP1 positive one (P<0.05). These results suggest the downregulation of p12 CDK2-AP1 to be related to tumor aggressiveness and a poor prognosis in patients with ESCC.

show abstract

“…However, endoscopic resection is a safe and effective option for the treatment of superficial esophageal cancers without any lymph node metastasis [19]. Moreover, endoscopy is also beneficial in staging of malignancies and in decision of treatment protocols [20].…”

Section: Discussionmentioning

confidence: 99%

A Retrospective Analysis of Esophagogastroduodenoscopies: A Single Center Experience

Çelebi¹,

Akdemir²,

Gürler³

et al. 2017

J Gastrointest Dig Syst

View full text Add to dashboard Cite

Goals: To present retrospective data on esophagogastroduodenoscopy (EGD) findings of patients who were admitted to a training and research hospital due to upper gastrointestinal system problems.Background: EGD is an interventional method used for diagnosing diseases of the esophagus, stomach, and duodenum. EGD is essential in the diagnosis of various benign and malign upper gastrointestinal diseases, as well as for therapy or disease follow-up.

show abstract

Prediction of lymph node status in patients with superficial esophageal carcinoma: analysis of 160 surgically resected cancers

Cited by 130 publications

References 17 publications

Endoscopic submucosal dissection for superficial esophageal squamous cell neoplasms

Endoscopic submucosal dissection for superficial esophageal squamous cell neoplasms

p12CDK2-AP1 is associated with tumor progression and a poor prognosis in esophageal squamous cell carcinoma

A Retrospective Analysis of Esophagogastroduodenoscopies: A Single Center Experience

Contact Info

Product

Resources

About