Prediction of Human Drug Clearance from Two Species: A Comparison of Several Allometric Methods

Goteti, Kosalaram; Garner, C. Edwin; Mahmood, Iftekhar

doi:10.1002/jps.21926

Cited by 13 publications

(13 citation statements)

References 63 publications

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“…Three animal species, however, may not be always available and one may want to conduct pharmacokinetic scaling based on 1 or 2 species. In general, 1 or 2 species scaling has not been found successful (Boxenbaum, 1982;Caldwell et al, 2004;Goteti et al, 2010).…”

Section: Discussionmentioning

confidence: 97%

Pharmacokinetic Allometric Scaling of Oligonucleotides

Mahmood

2011

Nucleic Acid Therapeutics

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The objective of this study was to evaluate the predictive performance of interspecies scaling of oligonucleotides to predict clearance and volume of distribution at steady state in humans from animal data. The human pharmacokinetic parameters were predicted using 1, 2, or at least 3 animal species. The results of the study indicated that the pharmacokinetic parameters of oligonucleotides can be predicted with reasonable accuracy in humans when at least 3 animal species are employed. On the other hand, allometric scaling based on 1 or 2 species or fixed coefficient or fixed exponent can be erratic and unreliable. Further work should be conducted in this direction.

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Section: Discussionmentioning

confidence: 97%

Pharmacokinetic Allometric Scaling of Oligonucleotides

Mahmood

2011

Nucleic Acid Therapeutics

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“…32 Interspecies prediction study with one or two species conducted by Tang et al implied that the use of three or more species in allometric scaling was not necessary for the prediction of human CL. 33 On the contrary, the usefulness of multiple species scaling for prediction was demonstrated by some literatures, 34,35 and in particular, Goteti et al pointed out that the prediction from more than three species was far more accurate than two-species scaling. 34 In the present study, the ROE method, multiple species allometry, exhibited better predictivity than single species allometry.…”

Section: Discussionmentioning

confidence: 98%

Comparative Assessment of Empirical and Physiological Approaches on Predicting Human Clearances

Tamaki

Kono²,

Kogayu³

et al. 2011

Journal of Pharmaceutical Sciences

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“…Gillooly et al reported an allometric relationship between metabolic rate and the developmental growth rate during embryogenesis, which has phylogenically and ontogenically invariant values [54]. Allometry was recently used in pharmacokinetics [55], predicting the pharmacokinetics of drugs [56,57]. In addition to allometry and Kleiber's law, other investigators have reported power law relationships in biomedicine; for example, Grandison and Morris reported that kinetic rate parameters showed a scale free relationship with the gene network and protein-protein interactions, which follows Benford's law [58].…”

Section: Methodsmentioning

confidence: 99%

Self-organization of developing embryo using scale-invariant approach

Tiraihi

2011

Theor Biol Med Model

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BackgroundSelf-organization is a fundamental feature of living organisms at all hierarchical levels from molecule to organ. It has also been documented in developing embryos.MethodsIn this study, a scale-invariant power law (SIPL) method has been used to study self-organization in developing embryos. The SIPL coefficient was calculated using a centro-axial skew symmetrical matrix (CSSM) generated by entering the components of the Cartesian coordinates; for each component, one CSSM was generated. A basic square matrix (BSM) was constructed and the determinant was calculated in order to estimate the SIPL coefficient. This was applied to developing C. elegans during early stages of embryogenesis. The power law property of the method was evaluated using the straight line and Koch curve and the results were consistent with fractal dimensions (fd). Diffusion-limited aggregation (DLA) was used to validate the SIPL method.Results and conclusionThe fractal dimensions of both the straight line and Koch curve showed consistency with the SIPL coefficients, which indicated the power law behavior of the SIPL method. The results showed that the ABp sublineage had a higher SIPL coefficient than EMS, indicating that ABp is more organized than EMS. The fd determined using DLA was higher in ABp than in EMS and its value was consistent with type 1 cluster formation, while that in EMS was consistent with type 2.

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Prediction of Human Drug Clearance from Two Species: A Comparison of Several Allometric Methods

Cited by 13 publications

References 63 publications

Pharmacokinetic Allometric Scaling of Oligonucleotides

Pharmacokinetic Allometric Scaling of Oligonucleotides

Comparative Assessment of Empirical and Physiological Approaches on Predicting Human Clearances

Self-organization of developing embryo using scale-invariant approach

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