2010
DOI: 10.1002/jps.21926
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Prediction of Human Drug Clearance from Two Species: A Comparison of Several Allometric Methods

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Cited by 13 publications
(13 citation statements)
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“…Three animal species, however, may not be always available and one may want to conduct pharmacokinetic scaling based on 1 or 2 species. In general, 1 or 2 species scaling has not been found successful (Boxenbaum, 1982;Caldwell et al, 2004;Goteti et al, 2010).…”
Section: Discussionmentioning
confidence: 97%
“…Three animal species, however, may not be always available and one may want to conduct pharmacokinetic scaling based on 1 or 2 species. In general, 1 or 2 species scaling has not been found successful (Boxenbaum, 1982;Caldwell et al, 2004;Goteti et al, 2010).…”
Section: Discussionmentioning
confidence: 97%
“…32 Interspecies prediction study with one or two species conducted by Tang et al implied that the use of three or more species in allometric scaling was not necessary for the prediction of human CL. 33 On the contrary, the usefulness of multiple species scaling for prediction was demonstrated by some literatures, 34,35 and in particular, Goteti et al pointed out that the prediction from more than three species was far more accurate than two-species scaling. 34 In the present study, the ROE method, multiple species allometry, exhibited better predictivity than single species allometry.…”
Section: Discussionmentioning
confidence: 98%
“…Gillooly et al reported an allometric relationship between metabolic rate and the developmental growth rate during embryogenesis, which has phylogenically and ontogenically invariant values [54]. Allometry was recently used in pharmacokinetics [55], predicting the pharmacokinetics of drugs [56,57]. In addition to allometry and Kleiber's law, other investigators have reported power law relationships in biomedicine; for example, Grandison and Morris reported that kinetic rate parameters showed a scale free relationship with the gene network and protein-protein interactions, which follows Benford's law [58].…”
Section: Methodsmentioning
confidence: 99%