“…The hepatic intrinsic clearance (CL’h,int) of KBP-7018 in various species was estimated from liver microsomal data using the following equation: 5 where 45 mg of microsomal protein per gram of liver tissue was applied to all species, and 87 g, 40 g, 30 g, 32 g, and 26 g of liver tissue per kilogram of body weight (BW) were used for mice, rats, dogs, monkeys, and humans, respectively. Then in vivo hepatic clearance of KBP-7018 was calculated by the well-stirred model 6 by where Q is hepatic blood flow (90 mL/min/kg, 55 mL/min/kg, 31 mL/min/kg, 44 mL/min/kg, and 21 mL/min/kg in mice, rats, dogs, monkeys, and humans, respectively), fu b and fu inc were the unbound fraction of protein binding in blood and microsomes, respectively, and CL int is the scaled intrinsic clearance determined from Equation 1 . fu inc was calculated by substitution of clog P (3.81) to the following equation for liver microsomes: …”