Prediction of heart rate variability on cardiac sudden death in heart failure patients: A systematic review

Wu, Lang; Jiang, Zhendong; Li, Changwei; Maoqin, Shu

doi:10.1016/j.ijcard.2014.04.176

Cited by 54 publications

(41 citation statements)

References 27 publications

(50 reference statements)

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“…In humans, a reduction of HR variability is an independent risk factor in several cardiovascular and systemic diseases (27,78). In the present study, despite the fact that basal HR did not differ among groups, the overall HR variability was significantly reduced in VAChT KD HOM mice.…”

Section: Discussioncontrasting

confidence: 53%

“…HR and AP variability have been extensively used as tools to access autonomic modulation of the cardiovascular system at either clinical (27,78) or experimental (38,65,74,75) levels. In humans, a reduction of HR variability is an independent risk factor in several cardiovascular and systemic diseases (27,78).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, a decrease in heart rate (HR) variability (27) and baroreflex sensitivity (BRS) (51) as well as an exaggerated cardiovascular response to stress have been described under these pathological conditions (10,11,49) and associated with higher cardiovascular risk (13,78).…”

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confidence: 99%

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Autonomic cardiocirculatory control in mice with reduced expression of the vesicular acetylcholine transporter

Durand

Becari

Tezini

et al. 2015

American Journal of Physiology-Heart and Circulatory Physiology

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In cardiovascular diseases, sympathetic tone has been comprehensively studied, whereas parasympathetic tone has received minor attention. The vesicular ACh transporter (VAChT) knockdown homozygous (VAChT KD HOM ) mouse is a useful model for examining the cardiocirculatory sympathovagal balance. Therefore, we investigated whether cholinergic dysfunction caused by reduced VAChT expression could adversely impact hemodynamic parameter [arterial pressure (AP) and heart rate (HR)] daily oscillation, baroreflex sensitivity, hemodynamic variability, sympathovagal balance, and cardiovascular reactivity to restraint stress. Wild-type and VAChT KD HOM mice were anesthetized for telemetry transmitter implantation, and APs and HRs were recorded 10 days after surgical recovery. Changes in HR elicited by methylatropine and propranolol provided the indexes of sympathovagal tone. Cardiovascular reactivity in response to a restraint test was examined 24 h after continuous recordings of AP and HR. VAChT KD HOM mice exhibited reduced parasympathetic and elevated sympathetic tone. Daily oscillations of AP and HR as well as AP variability were similar between groups. Nevertheless, HR variability, patterns with two dissimilar variations from symbolic analysis, and baroreflex sensitivity were reduced in VAChT KD HOM mice. The change in mean AP due to restraint stress was greater in VAChT KD HOM mice, whereas the tachycardic response was not. These findings demonstrate that the cholinergic dysfunction present in the VAChT KD HOM mouse did not adversely impact basal hemodynamic parameters but promoted autonomic imbalance, an attenuation of baroreflex sensitivity, and a greater pressure response to restraint stress. These results provide a framework for understanding how autonomic imbalance impacts cardiovascular function. daily hemodynamic oscillations; heart rate variability; mice; parasympathetic nervous system; vesicular acetylcholine transporter IN A NUMBER of cardiovascular diseases, e.g., heart failure, one of the most important changes to maintain cardiac output is sympathetic overactivity (79). This outcome is accompanied by a reduction in parasympathetic tone (47). Derangement of the autonomic nervous system seems to contribute to cardiac dysfunction and remodeling (17). However, although control of sympathetic tone in cardiovascular diseases has been extensively studied, less attention has been given to the role played by parasympathetic function (47).Regulation of cholinergic activity in the heart has recently emerged as an important step in the preservation of long-term cardiac function (64). Indeed, recent epidemiological evidence suggests improved outcomes for cardiovascular diseases in patients with Alzheimer's disease receiving anticholinesterase treatment (40,46). In addition, studies using acetylcholinesterase inhibitors in animals and patients with heart failure have demonstrated that it may be potentially useful for cardiovascular protection, resulting in beneficial effects for markers of cardiovascular risk and dysfu...

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Section: Discussioncontrasting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

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Autonomic cardiocirculatory control in mice with reduced expression of the vesicular acetylcholine transporter

Durand

Becari

Tezini

et al. 2015

American Journal of Physiology-Heart and Circulatory Physiology

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“…Heart rate and arterial pressure variability are extensively used to assess autonomic modulation of the cardiovascular system under clinical (Huikuri and Stein, 2013; Stein, 2013; Wu et al, 2014) and experimental conditions (Mansier et al, 1996; Wickman et al, 1998; Sabino et al, 2013). In the current study, the SAP variability in the time and frequency domains was similar between ELA-2KO and WT mice.…”

Section: Discussionmentioning

confidence: 99%

Elastase-2, a Tissue Alternative Pathway for Angiotensin II Generation, Plays a Role in Circulatory Sympathovagal Balance in Mice

et al. 2017

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In vitro and ex vivo experiments indicate that elastase-2 (ELA-2), a chymotrypsin-serine protease elastase family member 2A, is an alternative pathway for angiotensin II (Ang II) generation. However, the role played by ELA-2 in vivo is unclear. We examined ELA-2 knockout (ELA-2KO) mice compared to wild-type (WT) mice and determined whether ELA-2 played a role in hemodynamics [arterial pressure (AP) and heart rate (HR)], cardiocirculatory sympathovagal balance and baroreflex sensitivity. The variability of systolic arterial pressure (SAP) and pulse interval (PI) for evaluating autonomic modulation was examined for time and frequency domains (spectral analysis), whereas a symbolic analysis was also used to evaluate PI variability. In addition, baroreflex sensitivity was examined using the sequence method. Cardiac function was evaluated echocardiographically under anesthesia. The AP was normal whereas the HR was reduced in ELA-2KO mice (425 ± 17 vs. 512 ± 13 bpm from WT). SAP variability and baroreflex sensitivity were similar in both strains. The LF power from the PI spectrum (33.6 ± 5 vs. 51.8 ± 4.8 nu from WT) and the LF/HF ratio (0.60 ± 0.1 vs. 1.45 ± 0.3 from WT) were reduced, whereas the HF power was increased (66.4 ± 5 vs. 48.2 ± 4.8 nu from WT) in ELA-2KO mice, indicating a shift toward parasympathetic modulation of HR. Echocardiographic examination showed normal fractional shortening and an ejection fraction in ELA-2KO mice; however, the cardiac output, stroke volume, and ventricular size were reduced. These findings provide the first evidence that ELA-2 acts on the sympathovagal balance of the heart, as expressed by the reduced sympathetic modulation of HR in ELA-2KO mice.

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“…With regard to quality assessment, we used the Newcastle-Ottawa Quality Assessment Scale [14,15]. This scale evaluates the aspects of the population and sample methods, exposure and outcome descriptions, and statistical matching/adjustments of the data.…”

Section: Data Extraction and Quality Assessmentmentioning

confidence: 99%

Fish consumption and risk of myeloma: a meta-analysis of epidemiological studies

Wang

Zhu

et al. 2015

Cancer Causes Control

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This meta-analysis suggests that the highest versus lowest category of fish consumption is inversely associated with MM risk. Furthermore, a nonlinear dose-response relationship was suggested for the association. Because this evidence is based on a small number of retrospective studies with mixed quality and because high heterogeneity was detected, further prospective studies are warranted to validate our findings and better characterize the relationship.

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Prediction of heart rate variability on cardiac sudden death in heart failure patients: A systematic review

Cited by 54 publications

References 27 publications

Autonomic cardiocirculatory control in mice with reduced expression of the vesicular acetylcholine transporter

Autonomic cardiocirculatory control in mice with reduced expression of the vesicular acetylcholine transporter

Elastase-2, a Tissue Alternative Pathway for Angiotensin II Generation, Plays a Role in Circulatory Sympathovagal Balance in Mice

Fish consumption and risk of myeloma: a meta-analysis of epidemiological studies

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