Accurate quality prediction can find and eliminate quality hazards. It is difficult to construct an accurate quality mathematical model for the production of small samples with high dimensionality due to the influence of quality characteristics and the complex mechanism of action. In addition, overfitting scenarios are prone to occur in high-dimensional, small-sample industrial product quality prediction. This paper proposes an ensemble learning and measurement model based on stacking and selects eight algorithms as the base learning model. The maximal information coefficient (MIC) is used to obtain the correlation between the base learning models. Models with low correlation and strong predictive power were chosen to build stacking ensemble models, which effectively avoids overfitting and obtains better predictive performance. To improve the prediction performance as the optimization goal, in the data preprocessing stage, boxplots, ordinary least squares (OLS), and multivariate imputation by chained equations (MICE) are used to detect and replace outliers. The CatBoost algorithm is used to construct combined features. Strong combination features were selected to construct a new feature set. Concrete slump data from the University of California Irvine (UCI) machine learning library were used to conduct comprehensive verification experiments. The experimental results show that, compared with the optimal single model, the minimum correlation stacking ensemble learning model has higher precision and stronger robustness, and a new method is provided to guarantee the accuracy of final product quality prediction.