“…improvement by 1 grade or more at 4 weeks, our study shows, in agreement with most uncontrolled [14,19] and controlled [9,11,15,16,21,26] series, that PE is more likely to be helpful if begun early and pursued vigorously (see Table 4). improvement by 1 grade or more at 4 weeks, our study shows, in agreement with most uncontrolled [14,19] and controlled [9,11,15,16,21,26] series, that PE is more likely to be helpful if begun early and pursued vigorously (see Table 4).…”