Prediction of development of hepatocellular carcinoma using a new scoring system involving virtual touch quantification in patients with chronic liver diseases

Aoki, Tomoko; Iijima, Hiroko; Tada, Toshifumi; Kumada, Takashi; Nishimura, Takashi; Nakano, Chikage; Kishino, Kyohei; Shimono, Yoshihiro; Takata, Ryo; Ishii, Akio; Takashima, Tomoyuki; Sakai, Yoshiyuki; Aizawa, Nobuhiro; Nishikawa, Hiroki; Ikeda, Naoto; Iwata, Yoshinori; Enomoto, Hirayuki; Hirota, Seiichi; Fujimoto, Jiro; Nishiguchi, Shuhei

doi:10.1007/s00535-016-1228-7

Cited by 27 publications

(25 citation statements)

References 42 publications

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“…A recent study has reported that the value of ARFI elastography is closely associated with the risk of the development of HCC in patients with chronic liver diseases 27. In the present study, we also identified that the value of ARFI elastography before treatment correlated with the development of HCC in patients who achieved an SVR following DAA treatment.…”

Section: Discussionsupporting

confidence: 77%

Liver stiffness measurement predicts hepatocellular carcinoma development in patients treated with direct‐acting antivirals

et al. 2017

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Background and AimPredictive factors for hepatocarcinogenesis following eradication of hepatitis C virus by direct‐acting antivirals (DAAs) are unknown. The aim of the study was to investigate the relationships between liver stiffness (LS) using acoustic radiation force impulse (ARFI) erastograghy and the development of hepatocellular carcinoma (HCC) in patients who achieved sustained virological response (SVR) treated with DAA.MethodsIn this prospective study, we enrolled 263 hepatitis C patients with SVR who underwent ARFI before DAA treatment. Thirty patients had previous HCC.ResultsThe median LS value according to ARFI measurements was 1.34 m/s (range: 0.67–4.35). During the follow‐up period (median: 18.1 months), development of HCC occurred in 19 patients (7.2%; HCC occurrence in 7 patients and HCC recurrence in 12 patients). By multivariate Cox regression analysis, HCC history (hazard ratio [HR]: 10.634; 95% confidence interval [CI]: 4.13–27.37; P = 0.001), older age (HR: 4.638; 95% CI: 1.63–13.61; P = 0.004) and higher total bilirubin levels (HR: 4.189; 95% CI: 1.66–10.60; P = 0.002) were independent predictors for the development of HCC, and higher LS value (≥1.73 m/s) at baseline was an independent predictor for HCC occurrence (HR: 8.350; 95% CI: 1.62–43.09; P = 0.011). The cumulative recurrence of HCC was statistically similar according to the degree of LS in patients who were previously treated for HCC.ConclusionThe LS value at baseline is useful for predicting HCC occurrence. Thus, even if SVR is achieved, patients with higher LS at baseline must be followed carefully for HCC occurrence.

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Section: Discussionsupporting

confidence: 77%

Liver stiffness measurement predicts hepatocellular carcinoma development in patients treated with direct‐acting antivirals

et al. 2017

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“…The method for VTQ measurement by ARFI was conducted as reported elsewhere [10]. Briefly, using intercostal approach by one experienced sonologist, the examination for VTQ measurement was performed on the right lobe of the liver with a measurement depth of 2–3 cm below the liver surface.…”

Section: Methodsmentioning

confidence: 99%

“…Acoustic radiation force impulse (ARFI), which is a technology designed to measure shear wave-front at multiple sites to estimate tissue stiffness, is a novel ultrasound-based radiological technique for non-invasively assessing the degree of tissue stiffness [7,8,9,10]. This modality can evaluate the degree of liver fibrosis easily and accurately in the clinical settings [10,11].…”

Section: Introductionmentioning

confidence: 99%

“…This modality can evaluate the degree of liver fibrosis easily and accurately in the clinical settings [10,11]. ARFI elastography has two modes which involve qualitative response and quantitative response for virtual touch quantification (VTQ), and it measures transverse shear wave velocity values in meters/second (m/s).…”

Section: Introductionmentioning

confidence: 99%

“…ARFI elastography has two modes which involve qualitative response and quantitative response for virtual touch quantification (VTQ), and it measures transverse shear wave velocity values in meters/second (m/s). The shear wave velocity reflects tissue stiffness through a simple method: the stiffer the tissue, the higher shear wave velocity [7,8,9,10,11]. A recent meta-analysis demonstrated that ARFI elastography was a good method for evaluating the degree of liver fibrosis and had similar predictive value to transient elastography for significant fibrosis and liver cirrhosis (LC) [12].…”

Section: Introductionmentioning

confidence: 99%

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Impact of Virtual Touch Quantification in Acoustic Radiation Force Impulse for Skeletal Muscle Mass Loss in Chronic Liver Diseases

et al. 2017

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Background and aims: We sought to clarify the relationship between virtual touch quantification (VTQ) in acoustic radiation force impulse and skeletal muscle mass as assessed by bio-electronic impedance analysis in patients with chronic liver diseases (CLDs, n = 468, 222 males and 246 females, median age = 62 years). Patients and methods: Decreased skeletal muscle index (D-SMI) was defined as skeletal muscle index (SMI) <7.0 kg/m2 for males and as SMI <5.7 kg/m2 for females, according to the recommendations in current Japanese guidelines. We examined the correlation between SMI and VTQ levels and investigated factors linked to D-SMI in the univariate and multivariate analyses. The area under the receiver operating curve (AUROC) for the presence of D-SMI was also calculated. Results: In patients with D-SMI, the median VTQ level was 1.64 meters/second (m/s) (range, 0.93–4.32 m/s), while in patients without D-SMI, the median VTQ level was 1.11 m/s (range, 0.67–4.09 m/s) (p < 0.0001). In the multivariate analysis, higher VTQ was found to be an independent predictor linked to the presence of D-SMI (p < 0.0001). In receiver operating characteristic analysis, body mass index had the highest AUROC (0.805), followed by age (0.721) and VTQ (0.706). Conclusion: VTQ levels can be useful for predicting D-SMI in patients with CLDs.

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Risk Factors of Hepatocellular Carcinoma for Precision Personalized Care

Fujiwara

Liu

Athuluri-Divakar

et al. 2019

Molecular and Translational Medicine

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Prediction of development of hepatocellular carcinoma using a new scoring system involving virtual touch quantification in patients with chronic liver diseases

Abstract: The VFMAP score accurately predicted HCC in patients with chronic liver disease.

Cited by 27 publications

References 42 publications

Liver stiffness measurement predicts hepatocellular carcinoma development in patients treated with direct‐acting antivirals

Liver stiffness measurement predicts hepatocellular carcinoma development in patients treated with direct‐acting antivirals

Impact of Virtual Touch Quantification in Acoustic Radiation Force Impulse for Skeletal Muscle Mass Loss in Chronic Liver Diseases

Risk Factors of Hepatocellular Carcinoma for Precision Personalized Care

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