Prediction of Cardiovascular Outcomes With Left Atrial Size

Tsang, Teresa S.M.; Abhayaratna, Walter P.; Barnes, Marion E.; Miyasaka, Yoko; Gersh, Bernard J.; Bailey, Kent R.; Stephen, S.; Seward, James B.

doi:10.1016/j.jacc.2005.08.077

Cited by 692 publications

(455 citation statements)

References 26 publications

(26 reference statements)

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“…It is possible that LA volume measured by the more complicated biplane Simpson technique would be an even stronger predictor of CV events in hypertensive patients as suggested by Tsang et al 33 in a recent publication comparing prediction of CV outcomes by LA diameter to that of LA volume and LA area in 423 unselected patients referred for medical consultation, including echocardiography, at the Mayo Clinic. Of note, in their study, baseline measurements of LA diameter, LA area, and LA biplane volume all independently predicted subsequent risk of CV events over 3.5 years, including new-onset atrial fibrillation, congestive heart fail- ure, stroke, transient ischemic attack, myocardial infarction, coronary revascularization, and CV death, in Cox regression analyses (HRs: 9.0, 3.9, and 6.6, respectively).…”

Section: Discussionmentioning

confidence: 99%

Left Atrial Size and Risk of Major Cardiovascular Events During Antihypertensive Treatment

et al. 2007

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Abstract-The influence of left atrial size on cardiovascular events during antihypertensive treatment has not been reported previously from a long-term, prospective, randomized hypertension treatment trial. We recorded left atrial diameter by annual echocardiography and cardiovascular events in 881 hypertensive patients (41% women) with electrocardiographic left ventricular hypertrophy aged 55 to 80 (mean: 66) years during a mean of 4. S tudies in samples of the general population and in hypertensive patients have identified left atrial (LA) enlargement as a cardiovascular (CV) risk marker, in particular for atrial fibrillation and stroke. [1][2][3] We have shown previously that larger LA diameter in hypertensive patients is associated with other clinical and echocardiographic covariates of higher CV risk in hypertension, including higher body mass index, systolic blood pressure and age, left ventricular (LV) hypertrophy, eccentric LV geometry and mitral regurgitation by echocardiography, and atrial fibrillation. 4 However, less is known about the effect of antihypertensive treatment on LA diameter or on the relation between LA diameter and CV events during antihypertensive treatment. 5 Therefore, we evaluated the effect of losartan-or atenolol-based antihypertensive therapy on LA diameter and the relation between in-treatment LA diameter and CV events in the echocardiographic substudy of the Losartan Intervention For Endpoint reduction in hypertension (LIFE) study. Methods Patient PopulationThe LIFE echocardiography study was a prospectively planned substudy of the main LIFE study, which enrolled 960 of the 9193 participants in the parent trial for annual echocardiographic follow-up. 6,7 Patient characteristics and outcome results in the main LIFE study that randomly assigned patients aged 55 to 80 years with essential hypertension (baseline blood pressure: 160 to 200/95 to 115 mm Hg) and ECG LV hypertrophy (according to Cornell voltage duration or Sokolow-Lyon voltage criteria) to a mean of 4.8 years double-blind treatment with losartan compared with atenolol have been published, including the effects of treatment on CV events and regression of ECG LV hypertrophy. 6,8 Of the 960 patients enrolled in the LIFE echocardiographic substudy, 881 patients had LA diameter measured at enrollment and on Ն1 follow-up echocardiogram and, thus, were eligible for the present study (Table 1). Patients were classified as having isolated systolic hypertension if systolic blood pressure was Ն140 mm Hg and diastolic blood pressure Ͻ90 mm Hg, respectively, at baseline clinic visits. 9 Pulse pressure was calculated as the

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Section: Discussionmentioning

confidence: 99%

Left Atrial Size and Risk of Major Cardiovascular Events During Antihypertensive Treatment

et al. 2007

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“…The study population consisted of 78 consecutive and stable patients with HF, regardless of the etiology, with atrial atrial volume was obtained through the available software, using atrial measurements in the cephalocaudal, latero-lateral and oblique axes. The cutoff value used for left atrial volume index (LAVi) -left atrial volume/body surface area, was 28 mL/m² and 32 mL/m 2 , according to literature references 14,20 .…”

Section: Methodsmentioning

confidence: 99%

Dispersão da onda P e índice de volume do átrio esquerdo como preditores na insuficiência cardíaca

Silva¹,

N²,

Torres³

et al. 2013

Arq. Bras. Cardiol.

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“…Left atrial volume index is strongly associated with cardiovascular disease33 and a predictor of new HF irrespective of systolic left ventricular (LV) function 18, 34, 35. LAE is also an independent predictor for the development of early [American Heart Association (AHA) stage B] non‐ischaemic HF 36.…”

Section: Clinical Impact Of Atrial Remodelling and Relevance In Heartmentioning

confidence: 99%

Atrial remodelling in heart failure: recent developments and relevance for heart failure with preserved ejection fraction

et al. 2018

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Prediction of Cardiovascular Outcomes With Left Atrial Size

Abstract: Left atrial volume is a more robust marker of cardiovascular events than LA area or diameter in subjects with sinus rhythm. The predictive utility of LA size for cardiovascular events in AF was poor, irrespective of the method of LA size quantitation.

Cited by 692 publications

References 26 publications

Left Atrial Size and Risk of Major Cardiovascular Events During Antihypertensive Treatment

Left Atrial Size and Risk of Major Cardiovascular Events During Antihypertensive Treatment

Dispersão da onda P e índice de volume do átrio esquerdo como preditores na insuficiência cardíaca

Atrial remodelling in heart failure: recent developments and relevance for heart failure with preserved ejection fraction

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