Prediction of Cardiac Resynchronization Therapy Response in Dilated Cardiomyopathy Using Vortex Flow Mapping on Cine Magnetic Resonance Imaging

Abstract

ated with the development of Fontan-associated liver disease, 2 and with supraventricular arrhythmia in adolescent patients with congenital single ventricle. 3 We hypothesized that mechanical dyssynchrony causes VF to disrupt efficient output; therefore, CRT response may be associated with the occurrence of LV VF. The aims of the present study were to investigate the relationship between efficient LV ejection and VF, and whether CRT response could be predicted on VFM analysis in patients with dilated cardiomyopathy (DCM). Methods Patients This retrospective cohort study was approved by the institutional research ethics board and involved 20 HF patients with LVEF ≥40% and 25 DCM patients with LVEF <40% who were scheduled for CRT between January 2010 and December 2016. All patients underwent CMR, cardiac catheterization, transthoracic echocardiography, 12-lead electrocardiogram (ECG), and clinical examination at the same

The role of cardiac magnetic resonance in identifying appropriate candidates for cardiac resynchronization therapy — a systematic review of the literature

“…In patients with non-ischemic cardiomyopathy, a wide pattern of systolic left ventricular volume/time curves measured using CMR was significantly associated with CRT response compared to patients with a narrow pattern [54]. Summed maximum vortex flow can predict CRT response in DCM, while circumferential temporal delay and longitudinal temporal delay were not associated with CRT response [55]. Furthermore, a standard deviation of 16 segment time-to-peak radial thickness was significantly larger in responders compared with nonresponders [38].…”

“…However, six studies [17,18,16,14,23,19] included ischemic cardiomyopathy patients and one study [55] included only dilated cardiomyopathy patients. In ischemic cardiomyopathy patients, a posterolateral scar imaged using LGE-CMR, was an independent predictor of cardiovascular death or hospitalisations for HF [18].…”

“…Additionally, LV reverse remodelling following CRT implantation was affected by the total left ventricular scar burden [16]. In the setting of dilated cardiomyopathy, summed maximum vortex flow has been found to predict CRT response [55].…”