Prediction of bone strength by μCT and MDCT-based finite-element-models: How much spatial resolution is needed?

Bauer, Jan; Sidorenko, Irina; Müeller, Dirk; Baum, Thomas; Issever, Ahi Sema; Eckstein, F.; Rummeny, Ernst J.; Link, Thomas M.; Raeth, C.

doi:10.1016/j.ejrad.2013.10.024

Cited by 37 publications

(28 citation statements)

References 35 publications

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“…A previous study demonstrated that it is the resolution of raw data that primarily determines the accuracy of models as the bone volume fraction of bone volume/total volume was predominantly affected by the scanning resolution (22). The scanning resolution of the µ-CT system used in our study was 33.355 µm, which was enough to depict the microarchitecture of human trabecular bone (23,24). In another study, the recommended resolution in finite element models of trabecular bone was one quarter of trabecular thickness (25).…”

Section: Discussionmentioning

confidence: 92%

“…Although there were no significant differences between cubic and cylindrical µFE models, the positions of the trabecular bone core should be identical. In experimental compression tests, trabecular bone cores extracted from vertebral bodies are often used (23,32). In our study, cubic and cylindrical µFE models were constructed to investigate if there were differences between the two models.…”

Section: Discussionmentioning

confidence: 99%

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Influence of the shape of the micro-finite element model on the mechanical properties calculated from micro-finite element analysis

Wen

Yan

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. Assessing the biomechanical properties of trabecular bone is of major biological and clinical significance for the research of bone diseases, fractures and their treatments. Micro-finite element (µFE) models are becoming increasingly popular for investigating the biomechanical properties of trabecular bone. The shapes of µFE models typically include cube and cylinder. Whether there are differences between cubic and cylindrical µFE models has not yet been studied. In the present study, cubic and cylindrical µFE models of human vertebral trabecular bone were constructed. A 1% strain was prescribed to the model along the superior-inferior direction. E values were calculated from these models, and paired t-tests were performed to determine whether these were any differences between E values obtained from cubic and cylindrical models. The results demonstrated that there were no statistically significant differences in the E values between cubic and cylindrical models, and there were no significant differences in Von Mises stress distributions between the two models. These findings indicated that, to construct µFE models of vertebral trabecular bone, cubic or cylindrical models were both feasible. Choosing between the cubic or cylindrical µFE model is dependent upon the specific study design.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Influence of the shape of the micro-finite element model on the mechanical properties calculated from micro-finite element analysis

Wen

Yan

et al. 2017

Experimental and Therapeutic Medicine

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“…For example, 3D bone models have been constructed from DICOM data obtained from quantitative CT images. FEM has then been used to perform stress analyses to quantify strengths under external force from different directions and of different sizes [8]- [10]. Recent attempts that take individual patients' bone strengths into consideration have used CT data to understand the pathology of and assess therapeutic effects in osteoporosis [11] [12].…”

Section: Discussionmentioning

confidence: 99%

Biomechanical Study of the Effects of Balloon Kyphoplasty on the Adjacent Vertebrae

Takano¹,

Yonezawa²,

Todo³

et al. 2016

JBiSE

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We used the finite element method (FEM) to investigate the stress profiles of vertebrae in patients who underwent balloon kyphoplasty (BKP) for vertebral fracture. BKP is often performed for persistent pain after vertebral fractures. However, fractures are frequently reported in the adjacent vertebrae after BKP. The purpose was to clarify the mechanism of fractures that occur in the adjacent vertebrae after BKP. The subjects were two patients (first case: 74-year-old woman; second case: 88-yearold woman) who had BKP for osteoporotic vertebral fractures (L1). A bone analysis software program, Mechanical Finder, was used to construct three-dimensional finite element models (T11-L3) from computed tomographic (CT) digital imaging and communications in medicine (DICOM) data. Moment loadings were examined to evaluate stress concentrations on the vertebrae. Young's moduli were lower in the second case than in the first case at all vertebral levels. Maximum Drucker-Prager stresses after BKP were larger in the second case than in the first case for compression, flexion, extension, and axial rotation. Strain energy density decreased in L1 and increased in the adjacent vertebrae. Our results suggest that post-BKP fractures of the adjacent vertebrae not only are due to bone fragility, but also can be caused by increased rigidity in the vertebrae filled with bone cement, which increases stress concentration on the adjacent vertebrae and raises the likelihood of fracture.

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“…Studies indicated that the MDCT is of potential ability to be used for the FEA in the vitro and vivo tests [139,145]. MDCT based FEA provides the most reliable role tool to predict the bone strength [138,140,146], risk of fracture [139,147,148] and it's also more sensitive to monitor anti-osteoporosis [142,149] when compared to any of the conventionally used densitometric and microstructure standards.…”

Section: Assessment Of Bone Mechanical Propertymentioning

confidence: 99%

Application of quantitative computed tomography for assessment of trabecular bone mineral density, microarchitecture and mechanical property

et al. 2016

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a b s t r a c t a r t i c l e i n f oOsteoporosis is a common metabolic bone disease, causing increased skeletal fragility characterized by a low bone mass and trabecular microarchitectural deterioration. Assessment of the bone mineral density (BMD) is the primary determinant of skeletal fragility. Computed tomography (CT)-based trabecular microarchitectural and mechanical assessments are important methods to evaluate the skeletal strength. In this review, we focus the feasibility of QCT BMD measurement using a calibration phantom or phantomless. The application of QCT could extend the bone mineral density assessment to all patients who underwent a heart, lung, whole-body, and as well as all routine clinical implications of CT scan.

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Prediction of bone strength by μCT and MDCT-based finite-element-models: How much spatial resolution is needed?

Cited by 37 publications

References 35 publications

Influence of the shape of the micro-finite element model on the mechanical properties calculated from micro-finite element analysis

Influence of the shape of the micro-finite element model on the mechanical properties calculated from micro-finite element analysis

Biomechanical Study of the Effects of Balloon Kyphoplasty on the Adjacent Vertebrae

Application of quantitative computed tomography for assessment of trabecular bone mineral density, microarchitecture and mechanical property

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