Prediction of all-cause and cardiovascular mortality in elderly people from one low serum thyrotropin result: a 10-year cohort study

Parle, James; Maisonneuve, Patrick; Sheppard, M. C.; Boyle, Peter; Franklyn, Jayne A.

doi:10.1016/s0140-6736(01)06067-6

Cited by 623 publications

(487 citation statements)

References 10 publications

Supporting

Mentioning

416

Contrasting

Unclassified

Order By: Relevance

“…The clinical features of thyroid disorders tend to be nonspecific and fewer in elderly compared to younger patients and the symptoms are often confused with normal ageing process and coexisting diseases which may result in greater number of elderly patients being undiagnosed. 12 Results showed higher prevalence of thyroid dysfunction in females which is in accordance with the earlier studies. 2,13,14 It may be due to a sex difference in the prevalence of autoimmune diseases.…”

Section: Discussionsupporting

confidence: 91%

Lipid Profile of Patients with Thyroid Dysfunction in Ayurveda Hospital

Dixit

Dey²,

Suresh³

et al. 2014

Int Jour of Biomed Res

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 91%

Lipid Profile of Patients with Thyroid Dysfunction in Ayurveda Hospital

Dixit

Dey²,

Suresh³

et al. 2014

Int Jour of Biomed Res

View full text Add to dashboard Cite

“…In very old patients (>85 years), the biological response to hormone replacement may differ from that of younger populations, therefore hormone therapy in this group of individuals is called into question. With longevity as a concern, Gussekloo and coworkers (2004) found that in a cohort of 85 year olds, decreased levels of free thyroxine were strongly associated with longer life span, in agreement with an earlier report (Parle et al, 2001). These data contrast a study in middle-aged males with subclinical hypothyroidism showing higher rates of mortality from all causes (Imaizumi et al, 2004).…”

Section: Thyroid Hormonessupporting

confidence: 60%

Hormonal regulation of longevity in mammals

Brown‐Borg

2007

Ageing Research Reviews

View full text Add to dashboard Cite

Multiple biological and environmental factors impact the life span of an organism. The endocrine system is a highly integrated physiological system in mammals that regulates metabolism, growth, reproduction, and response to stress, among other functions. As such, this pervasive entity has a major influence on aging and longevity. The growth hormone, insulin-like growth factor-1 and insulin pathways have been at the forefront of hormonal control of aging research in the last few years. Other hormones, including those from the thyroid and reproductive system have also been studied in terms of life span regulation. The relevance of these hormones to human longevity remains to be established, however the evidence from other species including yeast, nematodes, and flies suggest that evolutionarily well-conserved mechanisms are at play and the endocrine system is a key determinant.

show abstract

“…Thus, decreased serum TSH levels have been reported to be associated with surrogate markers of cardiovascular mortality including carotid wall thickness (1), atrial fibrillation (2, 3), high plasma fibrinogen levels (4), and left ventricular hypertrophy (5,6). However, results of studies on the association between decreased serum TSH levels or subclinical hyperthyroidism (3,(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) and mortality are conflicting. With respect to cardiovascular mortality, most studies (3,11,12,18) and all meta-analyses (10,14,17) detected no association between decreased serum TSH levels or hyperthyroidism and mortality, while two studies did detect an association (7,9).…”

Section: Introductionmentioning

confidence: 99%

Decreased serum TSH levels are not associated with mortality in the adult northeast German population

Ittermann¹,

Häring²,

Sauer³

et al. 2010

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: Results of cohort studies on the association between decreased serum TSH levels and mortality are conflicting. Some studies demonstrated an increased mortality risk in subjects with decreased serum TSH levels, others did not. Even meta-analyses revealed contradictory results. We undertook the present study to investigate the association between decreased serum TSH levels and mortality in the large population-based Study of Health in Pomerania (SHIP). Design and methods: Data from 3651 individuals from SHIP without known thyroid disorders or thyroid treatment were analyzed. Serum TSH, free triiodothyronine, and free thyroxine levels were determined by immunochemiluminescent procedures. Decreased TSH was defined as serum TSH levels below 0.25 mIU/l. Cox regression was used to associate decreased TSH levels with mortality. Results: The median duration of follow-up was 8.5 years (30 126 person years). During follow-up, 299 individuals (6.9%) died corresponding to a death rate of 9.92 deaths per 1000 person years. Survival time was shorter in subjects with decreased serum TSH levels compared to euthyroid individuals. After adjustment for age and sex, however, there was no association between decreased serum TSH levels and all-cause mortality (hazard ratio: 0.95; 95% confidence interval: 0.67; 1.36). Likewise, decreased serum TSH levels were neither associated with cardiovascular nor with cancer mortality. Conclusions: There is no independent association of decreased serum TSH levels with all-cause, cardiovascular, and cancer mortality in the adult northeast German population. Although our study has some strengths, we cannot finally conclude on therapeutical implications in individuals with subclinical thyroid diseases.

show abstract

Prediction of all-cause and cardiovascular mortality in elderly people from one low serum thyrotropin result: a 10-year cohort study

Cited by 623 publications

References 10 publications

Lipid Profile of Patients with Thyroid Dysfunction in Ayurveda Hospital

Lipid Profile of Patients with Thyroid Dysfunction in Ayurveda Hospital

Hormonal regulation of longevity in mammals

Decreased serum TSH levels are not associated with mortality in the adult northeast German population

Contact Info

Product

Resources

About