Prediction of acute coronary syndromes by percutaneous coronary angioscopy in patients with stable angina

Uchida, Yasumi; Nakamura, Fúmitaka; Tomaru, Takanobu; Morita, Toshihiro; Oshima, Tadayuki; Sasaki, Tatsuumi; Morizuki, Satoru; Hirose, Junichi

doi:10.1016/0002-8703(95)90429-8

Cited by 168 publications

(106 citation statements)

References 23 publications

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“…21 In the present FA study, the plaques exhibiting Go on FA had a thin FC (≤100 µm), suggesting that plaques exhibiting Go on FA are vulnerable to disruption.…”

Section: Characteristic Fluorescence Of Ceramide In the Presence Of βmentioning

confidence: 47%

Detection of Ceramide, a Risk Factor for Coronary Artery Disease, in Human Coronary Plaques by Fluorescent Angioscopy

Uchida¹,

Uchida

Kobayashi

et al. 2017

Circ J

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“…21 In the present FA study, the plaques exhibiting Go on FA had a thin FC (≤100 µm), suggesting that plaques exhibiting Go on FA are vulnerable to disruption.…”

Section: Characteristic Fluorescence Of Ceramide In the Presence Of βmentioning

confidence: 47%

Detection of Ceramide, a Risk Factor for Coronary Artery Disease, in Human Coronary Plaques by Fluorescent Angioscopy

Uchida¹,

Uchida

Kobayashi

et al. 2017

Circ J

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“…23 The same problems occur with angioscopy, where flushing is needed to identify yellow plaques, which are associated with acute coronary syndromes. 24 Thermography can detect plaques with high temperature, which is related to inflammation. 25 Results of preliminary investigation in humans have been reported.…”

Section: Description Of the Linear Regression Model Regarding Thementioning

confidence: 99%

Characterizing Vulnerable Plaque Features With Intravascular Elastography

et al. 2003

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Background-In vivo detection of vulnerable plaques is presently limited by a lack of diagnostic tools. Intravascular ultrasound elastography is a new technique based on intravascular ultrasound and has the potential to differentiate between different plaques phenotypes. However, the predictive value of intravascular elastography to detect vulnerable plaques had not been studied. Methods and Results-Postmortem coronary arteries were investigated with intravascular elastography and subsequently processed for histology. In histology, a vulnerable plaque was defined as a plaque consisting of a thin cap (Ͻ250 m) with moderate to heavy macrophage infiltration and at least 40% of atheroma. In elastography, a vulnerable plaque was defined as a plaque with a high strain region at the surface with adjacent low strain regions. In 24 diseased coronary arteries, we studied 54 cross sections. In histology, 26 vulnerable plaques and 28 nonvulnerable plaques were found. Receiver operator characteristic analysis revealed a maximum predictive power for a strain value threshold of 1.26%. The area under the receiver operator characteristic curve was 0.85. The sensitivity was 88%, and the specificity was 89% to detect vulnerable plaques. Linear regression showed high correlation between the strain in caps and the amount of macrophages (PϽ0.006) and an inverse relation between the amount of smooth muscle cells and strain (PϽ0.0001). Plaques, which are declared vulnerable in elastography, have a thinner cap than nonvulnerable plaques (PϽ0.0001). Conclusions-Intravascular elastography has a high sensitivity and specificity to detect vulnerable plaques in vitro.

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“…Moreover, arteries accommodate plaque growth through outward displacement of the vessel wall, thereby preserving lumen cross-sectional area. 4 Other imaging techniques, such as intravascular ultrasound, 5 fast CT, 6 and angioscopy, 7 have all advanced our understanding of atherosclerosis, but these techniques are invasive and yield limited information about plaque composition.…”

mentioning

confidence: 99%

Noninvasive In Vivo Human Coronary Artery Lumen and Wall Imaging Using Black-Blood Magnetic Resonance Imaging

et al. 2000

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Background-High-resolution MRI has the potential to noninvasively image the human coronary artery wall and define the degree and nature of coronary artery disease. Coronary artery imaging by MR has been limited by artifacts related to blood flow and motion and by low spatial resolution. Methods and Results-We used a noninvasive black-blood (BB) MRI (BB-MR) method, free of motion and blood-flow artifacts, for high-resolution (down to 0.46 mm in-plane resolution and 3-mm slice thickness) imaging of the coronary artery lumen and wall. In vivo BB-MR of both normal and atherosclerotic human coronary arteries was performed in 13 subjects: 8 normal subjects and 5 patients with coronary artery disease. The average coronary wall thickness for each cross-sectional image was 0.75Ϯ0.17 mm (range, 0.55 to 1.0 mm) in the normal subjects. MR images of coronary arteries in patients with Ն40% stenosis as assessed by x-ray angiography showed localized wall thickness of 4.38Ϯ0.71 mm (range, 3.30 to 5.73 mm). The difference in maximum wall thickness between the normal subjects and patients was statistically significant (PϽ0.0001). Conclusions-In

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Prediction of acute coronary syndromes by percutaneous coronary angioscopy in patients with stable angina

Cited by 168 publications

References 23 publications

Detection of Ceramide, a Risk Factor for Coronary Artery Disease, in Human Coronary Plaques by Fluorescent Angioscopy

Detection of Ceramide, a Risk Factor for Coronary Artery Disease, in Human Coronary Plaques by Fluorescent Angioscopy

Characterizing Vulnerable Plaque Features With Intravascular Elastography

Noninvasive In Vivo Human Coronary Artery Lumen and Wall Imaging Using Black-Blood Magnetic Resonance Imaging

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