Prediction Factors of 6-Month Poor Prognosis in Acute Myocardial Infarction Patients

Yao, Jianhua; Xie, Yuan; Liu, Yang; Tang, Yu; Xu, Jiahong

doi:10.3389/fcvm.2020.00130

Cited by 11 publications

(10 citation statements)

References 45 publications

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“…The level of MYO is elevated by myocardial and skeletal muscle injury. In addition, MYO levels are elevated in diseases such as severe infection, severe trauma, and renal insufficiency ( 21 , 22 ).…”

Section: Discussionmentioning

confidence: 99%

Myoglobin and left ventricular ejection fraction as predictive markers for death in children with fulminant myocarditis

et al. 2022

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BackgroundFulminant myocarditis (FM) is an inflammatory process of the myocardium and an important cause of cardiac dysfunction in children; it is characterized by rapid onset, acute progression, and high mortality. The study sought to describe the clinical characteristics and prognostic factors in children with FM.MethodsThe study population consists of 37 consecutive patients admitted from May 2014 to December 2021 with a diagnosis of FM. According to the prognosis of children with FM during hospitalization, they were divided into “survival” group (25 cases) and “death” group (12 cases). A multivariate logistic regression analysis was performed to identify the independent predictors of in-hospital mortality in the patients, and receiver operating characteristic (ROC) curve was used to explore the predictive value of related factors.ResultsThe 37 children with FM had an average age of 8.35 ± 4.36 years old. Twenty-five of the patients survived and 12 died. Twenty-five of the children were discharged from the hospital after a series of active rescue treatments such as nutritional myocardial drugs, high-dose intravenous immunoglobulin (IVIG), glucocorticoids (GCs), temporary pacemaker (TP), extracorporeal membrane oxygenation (ECMO), and continuous renal replacement therapy (CRRT).Twelve of the children were classified into the death group because the resuscitation failed. The levels of procalcitonin (PCT), creatine kinase (CK), and myoglobin (MYO) in the death group were all higher than in the survival group (all P < 0.05), and the left ventricular ejection fraction (LVEF) in the death group was significantly lower than in the survival group (P = 0.002). The binary logistic regression analysis revealed that MYO [OR:1.006; 95%CI:(1–1.012); P = 0.045] and LVEF [OR: 0.876; 95% CI: (0.785–0.978); P = 0.019] were independent predictors of FM. ROC curve analysis showed that the area under ROC curve (AUC) of MYO and LVEF was [AUC:0.957; 95%CI:0.897~1] and [AUC:0.836; 95%CI:0.668~1], and the area under the combined ROC curve for MYO + LVEF was significantly higher than that for MYO or LVEF alone (P < 0.05), indicating that the MYO + LVEF combined diagnosis had a higher predictive value for FM.ConclusionThe levels of MYO and LVEF can be markers for prognosis of FM and can effectively evaluate the disease severity. Their combination can improve forecast accuracy; thus, the detection of the above-mentioned indexes possesses a higher value for clinical applications.

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Section: Discussionmentioning

confidence: 99%

Myoglobin and left ventricular ejection fraction as predictive markers for death in children with fulminant myocarditis

et al. 2022

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“…[ 12 , 13 ] As an independent risk factor of cardiovascular diseases, the increase of resting heart rate is positively associated with the mortality of cardiovascular events from AMI, which leads to the increase of myocardial oxygen consumption amount and the decrease in coronary artery perfusion. [ 14 , 15 ] Therefore, active clinical control of the resting heart rate has become one of the most important methods for treating AMI. β-blocker is widely used to slow down the heart rate, however, it is associated with several additional effects such as negative conduction, negative muscle strength, lower blood pressure, which limits its clinical application.…”

Section: Discussionmentioning

confidence: 99%

“…With the development of society, environmental and human lifestyle changes, the incidence of AMI has increased over recent years, even affecting younger generations and becoming one of the critical causes of death and disability [12,13] . As an independent risk factor of cardiovascular diseases, the increase of resting heart rate is positively associated with the mortality of cardiovascular events from AMI, which leads to the increase of myocardial oxygen consumption amount and the decrease in coronary artery perfusion [14,15] . Therefore, active clinical control of the resting heart rate has become one of the most important methods for treating AMI.…”

Section: Discussionmentioning

confidence: 99%

The efficacy of ivabradine in the treatment of acute myocardial infarction

Zhang

Sun²,

Yi³

2021

Medicine

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Background: Cardiovascular diseases have become a prominent threat to public health and quality of life. In recent years, some studies have reported that ivabradine can improve the cardiac function and prognosis of patients with acute myocardial infarction (AMI). Therefore, we perform a protocol for systematic review and meta-analysis to evaluate the efficacy of ivabradine for treating AMI. Methods: This protocol of systematic review and meta-analysis has been drafted under the guidance of the preferred reporting items for systematic reviews and meta-analyses protocols. We will search PubMed, Cochrane Library, Embase, Web of Science, and Medline databases for relevant studies. In addition, we will also collect 4 databases of China: China National Knowledge Infrastructure, China Biomedical Literature Database, China Science Journal Database, and Wan-fang Database. Risk of bias will be assessed using the Cochrane Handbook risk of bias assessment tool version (V.5.1.0). We will use STATA 16.0 software (Stata Corporation, College Station, TX) to perform data analysis. Results: The results of this systematic review and meta-analysis will be published in a peer-reviewed journal. Conclusion: We hypothesized that ivabradine can reduce the resting heart rate and improve heart function in patients with AMI.

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“…Enormous studies are dedicated to the issue of MI occurrence in IHD patients, particularly early MI diagnostic [15][16][17][18][19]. However, there is limited data regarding risk factors for UA transformation toward MI [20].…”

Section: Discussionmentioning

confidence: 99%

Blood Plasma Serotonin and von Willebrand Factor as Biomarkers of Unstable Angina Progression Toward Myocardial Infarction

et al. 2021

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Aim: To investigate the serotonin and von Willebrand factor (vWF) concentrations among unstable angina (UA) patients without and with progression toward myocardial infarction (outcome) and to assess the utility of both as prognostic markers of UA complications. Materials and methods: In observational cohort study, we recruited 103 patients with ischemic heart disease (the median age 65.0 (59.0-69.0) years, 45 females (43.7%)). After full set of investigations including high sensitive Troponin I test and 28-day follow-up period, we defined three groups: Group 1 - stable angina patients (n=22) as control, Group 2 - UA patients without outcome (n=71), Group 3 - UA patients with outcome (n=10). We analyzed the blood plasma serotonin content by the ion-exchange chromatography with measurement of serotonin on fluorescence spectrophotometer. VWF concentration was determined by ELISA. We compared the concentrations of observed parameters among the groups with the Kruskal-Wallis test (with post-hoc Mann-Whitney test with Bonferroni-Holm correction). We assessed binary logistic models, receiver operating characteristic curves, calculated sensitivity (Se), specificity (Sp), and positive likelihood ratio (LR+) for each indicator. Results: We registered elevation in serotonin concentration and decline in vWF concentration in Group 3 in comparison with Group 2 (22.670 (20.687-24.927) μg/ml vs 11.980 (8.120-15.000) μg/ml, p< 0.001, and 0.117 (0.109-0.120) rel.units/ml vs 0.134 (0.127-0.143) rel.units/ml, p < 0.001) and Group 1 (12.340 (10.052-13.619) μg/ml, p < 0.001, and 0.137 (0.127-0.156) rel.units/ml, p < 0.001), respectively. No significant differences in serotonin and vWF concentrations between Group 1 and Group 2 were detected (p=0.81 and p=0.36, respectively). The probability of outcome increased significantly (by 60.7% and 59.7%, LR+ 19.0 [6.0, 60.0] and 18.0 [3.9, 80.0]) if serotonin concentration was above 21.575 μg/ml (Se=80.0%, Sp=95.8%, AUC=0.975) and vWF concentration was below 0.114 rel.units/ml (Se=50.0%, Sp=97.2%, AUC=0.973), respectively. Conclusions: Serotonin and vWF as biomarkers are demonstrated promising results for rule-in the patients with risk of short-term UA progression toward myocardial infarction.

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Prediction Factors of 6-Month Poor Prognosis in Acute Myocardial Infarction Patients

Cited by 11 publications

References 45 publications

Myoglobin and left ventricular ejection fraction as predictive markers for death in children with fulminant myocarditis

Myoglobin and left ventricular ejection fraction as predictive markers for death in children with fulminant myocarditis

The efficacy of ivabradine in the treatment of acute myocardial infarction

Blood Plasma Serotonin and von Willebrand Factor as Biomarkers of Unstable Angina Progression Toward Myocardial Infarction

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