1986
DOI: 10.1210/jcem-62-2-368
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Prediction and Therapy of Intrauterine and Late-Onset Neonatal Hyperthyroidism*

Abstract: These studies in a mother and child describe the effects of multiple antibodies directed against the TSH receptor that influenced thyroid function in the fetus and infant. Blood was taken periodically for 6 months from a child (C3) whose mother (M) was known to have in her serum immunoglobulin G (IgG) that contained thyroid-stimulating antibody (TSAb), an inhibitor of TSAb and TSH binding and action, and an enhancer of TSH binding to its receptor, the last activity presumed to enhance both TSH and TSAb action.… Show more

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Cited by 94 publications
(32 citation statements)
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“…However, infants should continue to be followed clinically, because development of hyperthyroidism as late as day 45 of life has been described. [41][42][43][44] These recommendations for the first 2 weeks of life are consistent with those of others. 6, 9, 40 After 2 weeks of life, Besançon et al 9 recommend weekly clinical and biochemical evaluation for all newborns with positive TRAb levels until levels become negative, although it is not clear if data support this level of prolonged and intensive monitoring in all infants.…”
Section: Question 4: When Should Tsh and Ft4supporting
confidence: 83%
“…However, infants should continue to be followed clinically, because development of hyperthyroidism as late as day 45 of life has been described. [41][42][43][44] These recommendations for the first 2 weeks of life are consistent with those of others. 6, 9, 40 After 2 weeks of life, Besançon et al 9 recommend weekly clinical and biochemical evaluation for all newborns with positive TRAb levels until levels become negative, although it is not clear if data support this level of prolonged and intensive monitoring in all infants.…”
Section: Question 4: When Should Tsh and Ft4supporting
confidence: 83%
“…Systemic lupus erythematosus, rheumatoid arthritis, myasthenia gravis, vitiligo, idiopathic thrombocytopenic purpura and pernicious anemia also have been described in these children (15). In addition, GD is more common in children with Down's syndrome than in normal children (15,16).…”
Section: Introductionmentioning
confidence: 97%
“…It seems to be plausible, therefore, that serum TSAb was positive while serum TSBAb was negative in the present case during her second pregnancy, because the onset of neonatal hyperthyroidism is delayed when mother has both serum TSAb and TSBAb [21,22]. In the present patient, serum TSBAb which appeared after the delivery might be related to enhanced immunological activity after the delivery.…”
Section: Case Reportmentioning
confidence: 53%