Predicting who will have asthma at school age among preschool children

Savenije, Olga; Kerkhof, Marjan; Koppelman, Gerard H.; Postma, Dirkje S.

doi:10.1016/j.jaci.2012.05.007

Cited by 113 publications

(98 citation statements)

References 73 publications

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“…Early identification of asthma in a wheezing infant is difficult, and although predictive indexes have been developed, they lack sensitivity [4]. Therefore, there is still a need for more precise predictive clues, and age may be one of them.…”

Section: Discussionmentioning

confidence: 99%

“…Based on these and other studies, it may be said that many wheezing infants have only a transient type of disease; however, up to 40% of them will have asthma symptoms during school years. There have been advances in the development of methods to predict the risk of asthma in young children with wheeze, and asthma predictive indexes have been devised and tested [4].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Early patterns of wheezing in asthmatic and nonasthmatic children

Garcinuño¹,

Gandarillas²

2013

Eur Respir J

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The aim of this study was to describe the time patterns of wheezing in both asthmatic and nonasthmatic children during the first 36 months of life, and to determine whether there are asthma-related breakpoints in the incidence of wheezing.Data from a historical cohort of children followed from birth to 6 years (SLAM cohort) were used. Wheezing episodes until 36 months and asthma at 6 years were both recorded by a doctor. Monthly mean incidence rate of wheezing and rate ratio were calculated. Joinpoint regression models were built to identify breakpoints in the risk of wheeze.Complete information was available for 3739 children. Wheezing in the first 36 months was more frequent in asthmatic than in nonasthmatic children (rate ratio 2.62, 95% CI 1.81-3.78). Differences were appreciable within the first months and increased steadily thereafter because of a persistently high rate in asthmatic children. No breakpoint in the rate ratio could be identified. Asthmatic children exhibited a onephase curve of incidence and nonasthmatic children exhibited a two-phase curve. However, children with allergic asthma also displayed a two-phase curve.There is no identifiable breakpoint during the first 36 months of life at which the incidence of wheezing in asthmatic children begins to stand out. @ERSpublications Increased wheezing in asthmatic children from birth; different progression patterns for allergic and nonallergic asthma

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Early patterns of wheezing in asthmatic and nonasthmatic children

Garcinuño¹,

Gandarillas²

2013

Eur Respir J

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“…Many preschool children with wheeze become symptom-free between the ages of 3 and 8 years [1,2,10,11]. This distinguishes preschool wheeze from the more persistent asthma in later childhood and adulthood, and illustrates the heterogeneity of wheeze in this age group.…”

Section: Introductionmentioning

confidence: 88%

Classification and pharmacological treatment of preschool wheezing: changes since 2008

Brand

Caudri

Eber

et al. 2014

European Respiratory Journal

190

206

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“…444 The Asthma Predictive Index (API), based on the Tucson Children's Respiratory Study, is designed for use in children with four or more wheezing episodes in a year. 455 One study showed that children with a positive API have a 4-10-fold greater chance of developing asthma between the ages of 6-13 years than those with a negative API, and 95% of children with a negative API remained free of asthma.…”

Section: Risk Profilesmentioning

confidence: 99%