In the present research, the seismic behavior of steel structure of moment frame with CFT column has been evaluated. Finite element method has been used for numerical modeling. In the modeling, the surface and volume elements were used for steel and concrete, respectively. One, two, and three-story frames with and without CFT column under different earthquakes were investigated through dynamic analysis of the time history. The results show that the steel frame with CFT column, in terms of energy dissipation, has better behavior than the steel frame. The roof displacement in the different frames with CFT is less than that of the steel frame which indicate the improved performance of the frame. Using the CFT column in the column, in comparison with steel column, has led an increase in the bearing capacity of the structure under the earthquake. By adding the concrete to the column, the failure status of the structure will change. In the model with CFT, the failure occurs mainly in the location of the panel zone, while in the steel column under earthquake, the buckling occurs in the column. The reason for that may be due to steelconcrete interaction, which in turn, will increase the bearing capacity of the CFT column. Presence of CFT column in the steel frames will result in increased bearing capacity of the frame. Filling the steel frame with concrete prevents the inward buckling of the column and delays the local buckling of the steel wall.