Predicting Short‐Term Survival for Patients with Advanced Alzheimer's Disease

Volicer, Beverly J.; Hurley, Ann C.; Fabiszewski, Kathy J.; Montgomery, Paul; Volicer, Ladislav

doi:10.1111/j.1532-5415.1993.tb01891.x

Cited by 68 publications

(67 citation statements)

References 14 publications

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“…25,26,[36][37][38][39][40][41][42][43][44] Many studies have reported shorter survival for men with dementia as compared with women. 42, 45-48 Regarding ethnic differences, the literature is mixed, with some studies finding higher mortality for Caucasians with AD 26,49 and some others reporting no race differences.…”

Section: Discussionmentioning

confidence: 99%

Mediterranean diet and Alzheimer disease mortality

Scarmeas

Luchsinger²,

Mayeux³

et al. 2007

Neurology

293

127

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Section: Discussionmentioning

confidence: 99%

Mediterranean diet and Alzheimer disease mortality

Scarmeas

Luchsinger²,

Mayeux³

et al. 2007

Neurology

293

127

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“…Scores for each of the 10 items is 0 (normal) or 1 (abnormal), and total score ranges between 0 and 10, with higher scores reflecting high suffering levels of the patients. MSSE scores have been divided into three categories: low (0-3), intermediate (4)(5)(6) and high (7)(8)(9)(10). This classification has previously been shown to represent distinct subgroups, with significant differences between them, which have been tested for validity and reliability [14].…”

Section: Methodsmentioning

confidence: 99%

“…Several studies have investigated the 6-month survival of persons with a primary diagnosis of advanced dementia [8,9].…”

Section: Introductionmentioning

confidence: 99%

Their last 6 months: suffering and survival of end-stage dementia patients

2006

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Objective: to study possible interrelations existing between the Mini-Suffering State Examination (MSSE) scale and survival of end-stage dementia patients. Methods: a cohort study of 252 end-stage dementia patients with a 6-month follow-up period, conducted in a Division of Geriatric Medicine of a general hospital. We included 134 consecutive bedridden end-stage dementia patients admitted during a 36-month period, and surviving in the ward for <6 months. Interrelations between survival and admission MSSE scores were studied. Results: compared with patients surviving ≥6 months, those dying within 6 months were significantly older (P = 0.014). Mean survival time was 57.76 ± 9.73 days for the low MSSE score group (29 patients, MSSE 2.24 ± 0.99), 44.70 ± 5.99 days for the intermediate MSSE score group (53 patients, MSSE 4.92 ± 0.83) and 27.54 ± 4.16 days for the high MSSE score group (52 patients, MSSE 8.06 ± 1.00). Differences between the survival times of these three MSSE score groups were statistically significant (Kaplan-Meier Analysis Log Rank P = 0.0018, Breslow P = 0.0027). The Cox proportional hazard model of survival showed a significant interrelation of high MSSE scores and shorter survival (P = 0.013). Conclusions: documentation of a high-suffering level by the MSSE scale helps in identifying end-stage dementia patients expected to benefit from enrolment into a palliative care setting.

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“…Survival was poor after the onset of these complications. 7,11,12,26 These findings can be used to inform families and care providers that infections and eating problems should be expected and that their occurrence often indicates that the end of life is near. Families and providers should also understand that although these complications may be harbingers or even precipitants of death, as they are in other terminal diseases (e.g., the acquired immunodeficiency syndrome, cancer, and emphysema), it is the major illness, in this case dementia, that is the underlying cause of death.…”

Section: Discussionmentioning

confidence: 99%