Mediterranean diet and Alzheimer disease mortality

Scarmeas, Nikolaos; Luchsinger, José A.; Mayeux, Richard; Stern, Yaakov

doi:10.1212/01.wnl.0000277320.50685.7c

Cited by 295 publications

(152 citation statements)

References 76 publications

(21 reference statements)

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“…These findings are congruent with data from animal models showing that fat intake may be related not only to vascular risks but also to a direct effect of polyunsaturated fatty acids on Aβ accumulation [134]. Other evidence suggests that the "Mediterranean diet" is associated with a lower risk for AD [135] and a lower mortality once AD is established [136]. One hypothesis to explain this relationship is that the Mediterranean diet reduces vascular risks; however, a recent analysis suggests this is not the case [137].…”

Section: Epidemiologic Studiessupporting

confidence: 83%

Free radical-mediated damage to brain in Alzheimer's disease and its transgenic mouse models

Sonnen¹,

Breitner²,

Lovell³

et al. 2008

Free Radical Biology and Medicine

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Section: Epidemiologic Studiessupporting

confidence: 83%

Free radical-mediated damage to brain in Alzheimer's disease and its transgenic mouse models

Sonnen¹,

Breitner²,

Lovell³

et al. 2008

Free Radical Biology and Medicine

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“…For example, application of HFD for APP transgenic mice exacerbated pathological alterations in the brain and their memory deficits (6,7). In contrast, it is widely known that composite dietary patterns such as the Mediterranean diet, characterized by high intake of vegetables, unsaturated fatty acids, and wine, are related to lower risk for AD (8). These studies clearly indicate that there is an association between metabolic conditions and a higher risk of sporadic AD.…”

mentioning

confidence: 99%

Exercise Is More Effective than Diet Control in Preventing High Fat Diet-induced β-Amyloid Deposition and Memory Deficit in Amyloid Precursor Protein Transgenic Mice

Maesako

Uemura

Kubota

et al. 2012

Journal of Biological Chemistry

128

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Background: Exercise and diet control are fundamental approaches to metabolic conditions caused by high fat diet (HFD). Results: HFD-induced memory deficit and A␤ deposition were more ameliorated in the exercise-than in the diet controlinduced mice. Conclusion: Exercise was more effective than diet control in preventing HFD-induced AD development. Significance: Exercise has the highest priority in the prevention of AD.

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“…A study showed that individuals with medium and high adherence to the MeDi lived 1.33 and 3.91 years longer, respectively, than those with low adherence 37 .…”

Section: Evidence Of the Benefits Of The Mediterranean Diet On Cognitmentioning

confidence: 99%

“…However, we also consider that the MeDi, rather than single foods or nutrients, may constitute an effective preventive strategy with low cost, few side effects, and strong epidemiological health outcomes, which may translate to significantly better public health 14,21,37 .…”

Section: O N C L U S I O Nmentioning

confidence: 99%

Prevention of Alzheimer's disease: The role of the Mediterranean diet

Sousa

Guimarães

2015

Rev. Nutr.

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Rev. Nutr., Campinas, 28(6):691-703, nov./dez., 2015 Revista de Nutrição A B S T R A C TAlzheimer's disease rates have been increasing exponentially and are now considered a 21 st century epidemic. It contributes substantially to the morbidity and mortality of older adults. Thus, Alzheimer's disease is a growing major public health concern with a profuse socioeconomic impact. In addition, the existing pharmacological agents only offer modest symptomatic relief and can neither address the progressive neurodegeneration nor cure the disease. Therefore, finding effective preventive and therapeutic measures that delay the onset or reverse the course of the disease is crucial. Several studies have shown that lifestyle factors may play a central role in reducing the risk of developing Alzheimer's disease or, at least, in delaying its clinical symptoms. Among these disease-modifying factors, healthy nutrition has drawn much attention given that it might strongly influence the risk of cognitive decline, dementia, and Alzheimer's disease. Such healthy dietary pattern is the Mediterranean diet. The Mediterranean diet may play a protective role against age-related changes in cognitive function, pre-dementia syndromes, and dementia. Therefore, it may constitute an effective preventive strategy for Alzheimer's disease, with low costs and few side effects. Importantly, these promising preventive measures may translate into strong epidemiological health outcomes, which might lead to a significant progress in public health. An online search was conducted in PubMed in order to revise the literature concerning the association between diet and dementia, specifically, if a higher adherence to the Mediterranean diet pattern is related to lower risk of developing Alzheimer's disease, and to understand the possible mechanisms that may explain such association.Keywords: Alzheimer disease. Diet. Mediterranean diet. Prevention. R E S U M O I N T R O D U C T I O NSince its first description in the beginning of the XX century, Alzheimer's disease has gone from a rarely reported disorder to one of the most frequent causes of disability in older adults. Accordingly, cognitive decline and particularly Alzheimer's disease are major contributors to morbidity and mortality worldwide. Numerous studies performed in the last decades have given essential insights into the nature of Alzheimer's disease and importantly, into the magnitude of the problem. However, research on Alzheimer's disease is still an endless challenge, particularly in the area of prevention 1 .Since the times of Ancient Greece, lifestyle modifications, such as diet and exercise, can recognizably prevent or even treat several diseases, a concept that is well reflected on the well-known Hippocratic saying, "Let food be your medicine, let medicine be your food" (p.1295) 2 . Recently, many efforts have been made to describe the association between diet and cognitive function given that several studies have reported that nutrient intake and dietary practices strongly influence the...

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Mediterranean diet and Alzheimer disease mortality

Abstract: Background-We previously reported that the Mediterranean diet (MeDi) is related to lower risk for Alzheimer disease (AD). Whether MeDi is associated with subsequent AD course and outcomes has not been investigated.

Cited by 295 publications

References 76 publications

Free radical-mediated damage to brain in Alzheimer's disease and its transgenic mouse models

Free radical-mediated damage to brain in Alzheimer's disease and its transgenic mouse models

Exercise Is More Effective than Diet Control in Preventing High Fat Diet-induced β-Amyloid Deposition and Memory Deficit in Amyloid Precursor Protein Transgenic Mice

Prevention of Alzheimer's disease: The role of the Mediterranean diet

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