The current research aimed to study the relation between Mindfulness, sleep quality and attitude toward Drug use among a sample of University Students, and to identify the differences between the sample in Mindfulness, Sleep quality and attitude toward Drug use according to gender and grade, in addition to identify the relative contribution for Mindfulness in predicting sleep quality and attitude toward Drug use among university students, the sample consisted of ( 734) , (245) males, (489) females, their ages ranged between 18-27 years, their mean age was 19,98 Years with a standard deviation of 2,371 years. They answered Mindfulness scale , prepared by Gu et al., (2016), the sleep quality scale by Abd Elstar and Abd Elhamied(2021), and attitude toward Drug use Scale prepared by Morsi (1998). The results indicated the following: There were statistically significant differences in observion subscale, in side of female students, while male students were highter in both description and not interacting with inner experiences subscales.The results also revealed that there were differences between male and female students in both quality of sleep and the attitude toward drug use, where the differences in the side of male students.The results also indicated that there were differences in mindfulness and the differences were in the direction of postgraduate students.In attitude toward drug use scale , the differences were in the direction of the fourth year students, While in sleep quality scale, the differences were in side of the first year students.The results also revealed that there was a positive relationship between mindfulness and sleep quality, and a negative relationship between mindfulness and the attitude toward drug use..Finally, the results showed the ability of mindfulness to predict both the quality of sleep and the attitude toward drug use.