Predicting preterm birth: where do the major challenges lie?

Pereira, Leonardo; Caughey, Aaron B.

doi:10.1038/jp.2012.54

Cited by 2 publications

(1 citation statement)

References 8 publications

(7 reference statements)

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“…After injection, glucocorticoid bioactivity in the fetus lasts for several days ( 9 ) and can exert long-lasting effects upon the hypothalamic–pituitary–adrenal (HPA) axis and cognition in children ( 10 , 11 ). Of note, 30–80% of women with symptoms of preterm birth have not delivered 14 days later ( 12 ), and more than half of the women who received ACS delivered later than one week after treatment or after 34 weeks of gestation ( 13 ), among them one third after gestation week 37 ( 14 ). Especially this population of neonates is likely to encounter more harm than benefits from the prenatal treatment with glucocorticoids.…”

Section: Introductionmentioning

confidence: 99%

Prenatal Administration of Betamethasone Causes Changes in the T Cell Receptor Repertoire Influencing Development of Autoimmunity

et al. 2017

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Prenatal glucocorticoids are routinely administered to pregnant women at risk of preterm delivery in order to improve survival of the newborn. However, in half of the cases, birth occurs outside the beneficial period for lung development. Glucocorticoids are potent immune modulators and cause apoptotic death of immature T cells, and we have previously shown that prenatal betamethasone treatment at doses eliciting lung maturation induce profound thymocyte apoptosis in the offspring. Here, we asked if there are long-term consequences on the offspring’s immunity after this treatment. In the non-obese diabetic mouse model, prenatal betamethasone clearly decreased the frequency of pathogenic T cells and the incidence of type 1 diabetes (T1D). In contrast, in the lupus-prone MRL/lpr strain, prenatal glucocorticoids induced changes in the T cell repertoire that resulted in more autoreactive cells. Even though glucocorticoids transiently enhanced regulatory T cell (Treg) development, these cells did not have a protective effect in a model for multiple sclerosis which relies on a limited repertoire of pathogenic T cells for disease induction that were not affected by prenatal betamethasone. We conclude that prenatal steroid treatment, by inducing changes in the T cell receptor repertoire, has unforeseeable consequences on development of autoimmune disease. Our data should encourage further research to fully understand the consequences of this widely used treatment.

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Section: Introductionmentioning

confidence: 99%

Prenatal Administration of Betamethasone Causes Changes in the T Cell Receptor Repertoire Influencing Development of Autoimmunity

et al. 2017

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Poly(cytosine)‐templated Silver Nanoclusters as Fluorescent Biosensor for Highly Sensitive Detection of Uric Acid

Gong

Jiang

et al. 2016

J Chinese Chemical Soc

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Uric acid (UA) is an important biomarker in urine and serum samples for early diagnosis. This study re‐ ports a fluorescent biosensor based on Poly(cytosine)‐templated silver nanoclusters (C‐Ag NCs) and uricase for the highly sensitive and fast detection of UA. The strong fluorescence of the C‐Ag NCs prepared from poly (cytosine) nucleotides templates could be sensitively quenched by trace amount of H2O2, which produced from oxidation reaction of UA catalyzed by uricase. This biosensor exhibits two linear ranges as 50 nM∼50 μM and 50 μM∼400 μM, with a detection limit of 50 nM. The sensitivity of the biosensor is considerably improved compared with the methods reported in the literature. Furthermore, the detection ability of uric acid in serum samples is confirmed and this C‐Ag NCs‐based uric acid biosensor shows good promise of practical application.

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Predicting preterm birth: where do the major challenges lie?

Cited by 2 publications

References 8 publications

Prenatal Administration of Betamethasone Causes Changes in the T Cell Receptor Repertoire Influencing Development of Autoimmunity

Prenatal Administration of Betamethasone Causes Changes in the T Cell Receptor Repertoire Influencing Development of Autoimmunity

Poly(cytosine)‐templated Silver Nanoclusters as Fluorescent Biosensor for Highly Sensitive Detection of Uric Acid

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