Predicting individualized mortality probabilities for patients with squamous cell carcinoma of the maxilla: Novel models with clinical and histopathological predictors

Abstract

Background The aim of this article was to develop prediction models that calculate postoperative 2‐ and 5‐year mortality probabilities of patients with squamous cell carcinoma of the maxilla (MSCC). Methods Data were collected from the medical records of patients who had been operated between 2000 and 2015 for MSCC. Potential clinical and histopathological predictors were identified. Confounding‐(un)adjusted multivariate Cox and logistic regression models were computed with stepwise backward selection. Internal validation was performed to assess calibration and discriminatory ability. Results Ninety‐five patients with MSCC were included. Two‐year follow‐up was complete, and 85 patients had 5‐year follow‐up. Age, neck treatment, surgical margins, bone invasion, spindle growth, and vasoinvasive growth were associated with mortality. Models were adjusted for confounding with Charlson's comorbidities index. C‐indexes were .841 and .770 respectively, and .838 and .749 after bootstrapping. Conclusion The MSCC‐specific mortality probability can be calculated with new prediction models.

Determination of Significant Prognostic Factors for Maxillary Gingival Squamous Cell Carcinoma in 90 Cases

“…MGSCC is relatively rare, and few reports have analysed the treatment strategies and prognostic factors in a signi cant number of cases. [10] In addition, since palatal cancer involving the hard palate and MGSCC show similar clinical ndings, some reports have analysed the combination, but few reports have analysed only MGSCC. [11][12][13][14][15][16] This study analysed the management methods and prognostic factors of MGSCC in 90 cases.…”

Local recurrence and survival after treatment of oral squamous cell carcinoma of the maxilla: A systematic review and meta-analysis

“…An overview of all the included studies and their characteristics is presented in Table 1 [2,[9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27]. All 20 included studies were observational.…”

“…Sample sizes varied between 20 -199 patients. The sum of all included MSCC patients is 1531 (the samples of Slieker et al [2] and Slieker et al [27] are the same and therefore counted once). All studies had solely included patients with squamous cell carcinoma.…”

“…Various factors were correlated with OS (Table 4). Age [2,20], advanced tumour stage (T3-4) [10,17,22,24,25] and positive surgical margins [2, 11-13, 17, 20, 25] were all correlated with decreased OS rates in multiple studies.…”

Determination of Significant Prognostic Factors for Maxillary Gingival Squamous Cell Carcinoma in 90 Cases

“…Univariable analyses of prognostic factors for overall survival rate is relatively rare, and few reports have analysed the treatment strategies and prognostic factors in a signi cant number of cases [10]. In addition, since palatal cancer involving the hard palate and MGSCC show similar clinical ndings, some reports have analysed the combination, but few reports have analysed only MGSCC [11][12][13][14][15][16].…”