Predicting Dental Caries Outcomes in Children

Divaris, Kimon

doi:10.1177/0022034515620779

Cited by 86 publications

(108 citation statements)

References 61 publications

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“…For the trial, the children could be randomized into 2 arms -integral treatment and follow-up based on caries risk assessment (experimental group), and integral treatment and follow-up with no caries risk assessment (control group) -and patient-relevant outcomes should be evaluated at the end of the study. Until now, the assertion that caries risk assessment is a clinically relevant procedure is based on studies with inferior methodology [Divaris, 2016] and experts' opinion [Young et al, 2007;Twetman et al, 2013;Mejare et al, 2014;Divaris, 2016;Kuhnisch et al, 2016].…”

Section: Discussionmentioning

confidence: 99%

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Presence of Initial Caries Lesions as a Risk Factor for Caries in Preschool Children: A Cohort Study

Guedes¹,

Piovesan²,

Ardenghi³

et al. 2017

Caries Res

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The aim of this study was to evaluate the influence of initial noncavitated caries lesions on cavitated caries increment in preschool children. A 2-year cohort study was designed to include the participants of a survey on dental caries performed in 2010. Preschool children (12-59 months old) were examined for dental caries and classified as children with no caries lesions, with only initial lesions, with at least 1 moderate caries lesion, and with extensive lesions. Socioeconomic data were also collected. After 2 years, 466 children were re-examined (follow-up rate of 72.9%) only for cavitated lesions. Association between caries incidence at 2 levels of severity and caries experience and other variables was evaluated using hierarchical Poisson regression analysis. The children with moderate and extensive caries lesions at baseline presented a higher risk of presenting both outcomes than the children with no caries lesions. Nevertheless, the children with only initial lesions had a higher risk of developing at least 1 new cavitated carious lesion, but not for a more severe increment in caries. Subgroup analysis stratified by the children's age showed that the influence of the presence of initial caries lesions on cavitated caries increment was only observed in children aged 12-35 months. In conclusion, although the presence of moderate and extensive lesions at baseline is a significant predictor for cavitated caries increment after 2 years in preschool children at all ages, the presence of only initial caries lesions is also associated, but with less severe caries incidence.

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Section: Discussionmentioning

confidence: 99%

“…tors to predict the development of new caries lesions [Leong et al, 2013;Twetman et al, 2013;Mejare et al, 2014;Senneby et al, 2015;Divaris, 2016].…”

mentioning

confidence: 99%

Presence of Initial Caries Lesions as a Risk Factor for Caries in Preschool Children: A Cohort Study

Guedes¹,

Piovesan²,

Ardenghi³

et al. 2017

Caries Res

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“…Thus, it is necessary to improve and standardize microbial community profiling in early oral disease by refining diversity at deeper taxonomic levels (e.g., species and strains). Additionally, adopting a system-level approach to profile microbemicrobe and microbe-metabolite interactions in the early oral ecosystem should improve our understanding of microbial function in disease, beyond taxonomic characterizations [65, 83]. …”

Section: The Oral Microenvironment and Biomarkers Of Oral Disease mentioning

confidence: 99%

The Oral Microbiome of Children: Development, Disease, and Implications Beyond Oral Health

2016

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In the era of applied meta-omics and personalized medicine, the oral microbiome is a valuable asset. From biomarker discovery to being a powerful source of therapeutic targets, and to presenting an opportunity for developing non-invasive approaches to health care, it has become clear that oral microbes may hold the answer for understanding disease, even beyond the oral cavity. Although our understanding of oral microbiome diversity has come a long way in the past 50 years, there are still many areas that need to be fine-tuned for better risk assessment and diagnosis, especially in early developmental stages of human life. Here, we discuss the factors that impact development of the oral microbiome, and explore oral markers of disease, with a focus on the early oral cavity. Our ultimate goal is to put different experimental and methodological views into perspective for better assessment of early oral and systemic disease at an early age, and discuss how oral microbiomes- at the community level, could provide improved assessment in individuals, and populations at risk.

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“…However, the question of interest is how accurately can we identify individuals or tooth surfaces/sites at risk by assessing risk factors? Limited evidence on the validity of available methods used for risk assessments has been reported in the literature [Tellez et al, 2013;Twetman et al, 2013;Mejàre et al, 2014;Senneby et al, 2015;Divaris, 2016]. The ability of multivariable or single determinant models to predict caries in children and adolescents was recently investigated in a systematic review [Mejàre et al, 2014].…”

Section: Risk Assessment For Occlusal Caries Lesion Activity Incidenmentioning

confidence: 99%

Occlusal Caries: Biological Approach for Its Diagnosis and Management

et al. 2016

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The management of occlusal caries still remains a major challenge for researchers as well as for general practitioners. The present paper reviews and discusses the most up-to-date knowledge and evidence of the biological principles guiding diagnosis, risk assessment, and management of the caries process on occlusal surfaces. In addition, it considers the whole spectrum of the caries process on occlusal surfaces, ranging from the molecular ecology of occlusal biofilms to the management of deep occlusal caries lesions. Studies using molecular methods with focus on biofilms in relation to occlusal caries should explore the relationship between the function and the structural composition of these biofilms to understand the role of occlusal biofilms in caries development. State-of-the-art measures to evaluate risk for occlusal caries lesion activity, caries incidence, and progression should include the assessment of the occlusal biofilm and the stage of tooth eruption. Careful clinical examination of non-cavitated lesions, including assessment of the lesion activity status, remains the major tool to determine the immediate treatment need and to follow on the non-operative treatment outcome. Even medium occlusal caries lesions in the permanent dentition may be treated by non-invasive fissure sealing. By extending the criteria for non-invasive treatments, traditional restoration of occlusal surfaces can be postponed or even avoided, and the dental health in children and adolescents can be improved. Selective removal (incomplete) to soft dentin in deep carious lesions has greater success rates than stepwise excavation. Selective (complete) removal to firm dentin has a lower success rate due to increased pulp exposure.

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Predicting Dental Caries Outcomes in Children

Cited by 86 publications

References 61 publications

Presence of Initial Caries Lesions as a Risk Factor for Caries in Preschool Children: A Cohort Study

Presence of Initial Caries Lesions as a Risk Factor for Caries in Preschool Children: A Cohort Study

The Oral Microbiome of Children: Development, Disease, and Implications Beyond Oral Health

Occlusal Caries: Biological Approach for Its Diagnosis and Management

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