Predicting clinical behaviour of breast phyllodes tumours: a nomogram based on histological criteria and surgical margins

li, huihua

doi:10.1136/jclinpath-2011-200368

Cited by 253 publications

(250 citation statements)

References 44 publications

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“…Occasionally, recurrent tumors show increased cellularity and more aggressive histological features than the original lesion. (16) In most patients, local recurrence is isolated and is not associated with the development of distant metastasis as also in our case. Tumor size and surgical margins were found to be the principal determinant of local recurrence (10) .…”

Section: Case Reportsupporting

confidence: 48%

“…(15) Local recurrence in phyllodes tumors is seen between 10-20% and has been associated with inadequate local excision and narrow surgical margins. (16) Recurrences in malignant phyllodes are early to occur than in benign disease but there is no clear association with rate of recurrence. Local recurrence usually occurs within few years of surgery and histologically resembles the original tumor.…”

Section: Case Reportmentioning

confidence: 99%

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A Rare Case of Recurrent Malignant Phyllodes Tumor in Young Female

Pasha¹

2017

JMSCR

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Section: Case Reportsupporting

confidence: 48%

Section: Case Reportmentioning

confidence: 99%

A Rare Case of Recurrent Malignant Phyllodes Tumor in Young Female

Pasha¹

2017

JMSCR

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“…Juvenile or giant fibroadenoma is a rare pathology usually presenting in adolescent and young girls (10e18 years old) that is characterized by massive and rapid enlargement of an encapsulated mass [8]. The etiology is believed to be an end-organ hypersensitivity to normal levels of gonadal hormones.…”

Section: Giant Fibroadenomas Of the Breastmentioning

confidence: 99%

Has color Doppler a role in the evaluation of mammary lesions?

Busilacchi

Draghi

Preda

et al. 2012

Journal of Ultrasound

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KEYWORDSColor Doppler; Breast; Mammary lesions.Abstract Has color Doppler a role in the evaluation of mammary lesions? A schematic review of color Doppler diagnostic criteria, indicating a benign or malignant lesion, are described. Malignant tumors have a tendency to show increased vascularization, but avascular tumors may be found as well as hypervascular benign tumors. Number of vessels, blood-flow velocity, and intra-tumoral vessel resistance assessed by color Doppler ultrasonography don't permit clear differentiation between malignant and benign tumors, but intra-tumoral blood-flow analysis well correlates with aggressiveness and histological grade of the mass, so a preoperative assessment using Color Doppler may give preliminary prognostic informations useful for therapeutic planning. Color Doppler ultrasound may be valuable also in assessing the efficacy of neoadjuvant chemotherapy and in particular of antiangiogenesis treatments. Color Doppler ultrasound has many other useful applications in the evaluation of diseases of the female and male breast, that are reviewed in the paper. Color Doppler however is not conceived as a stand-alone examination, but associated with Bmode ultrasound that is quite effective as a diagnostic tool, often not requiring Doppler informations.Sommario Il color Doppler ha un ruolo nella valutazione delle lesioni mammarie? Viene presentata una rassegna schematica dei criteri diagnostici color Doppler, che indicano la benignità o la malignità di una lesione. I tumori maligni hanno la tendenza a mostrare vascolarizzazione aumentata, ma si possono trovare tumori maligni avascolari, così come tumori benigni ipervascolarizzati. Numero di vasi, velocità del flusso, indici di resistenza non consentono una sicura differenziazione tra tumori maligni e benigni, ma l'analisi del flusso intratumorale si correla bene con l'aggressività ed il grado istologico della neoplasia, quindi una valutazione preoperatoria, utilizzando il Color Doppler, può fornire informazioni prognostiche preliminari utili per la pianificazione terapeutica. * Corresponding author.E-mail address: giabusil@tin.it (P. Busilacchi). Può essere utile anche per valutare l'efficacia della chemioterapia neoadiuvante e, in particolare di trattamenti antiangiogenesi. Il color Doppler ha molte altre applicazioni nella valutazione delle patologie della mammella femminile e maschile, che vengono esaminati nel presente articolo. Il color Doppler, tuttavia, non è concepito come un esame autonomo, ma associata all'ecografia B-mode, che è molto efficace come strumento diagnostico delle lesioni mammarie e che, spesso, non richiede informazioni Doppler. ª

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“…Tumors were classified into benign, borderline, and malignant on the basis of histological features according to the WHO classification of breast tumors as previously described. 13 Histological features included stromal hypercellularity, stromal atypia, tumor microscopic margins, stromal mitotic activity, and stromal overgrowth. Patient follow-up was retrieved from medical records.…”

Section: Patients and Tumorsmentioning

confidence: 99%

CD117 expression in breast phyllodes tumors correlates with adverse pathologic parameters and reduced survival

et al. 2015

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and 5 Duke-NUS Graduate Medical School, Singapore CD117 (c-kit) is a type III receptor tyrosine kinase encoded by the KIT gene. Deregulation of expression and mutations in the gene are implicated in various tumors. Reports of CD117 expression in phyllodes tumors have been controversial. We aim to investigate the protein expression of CD117 and mutations in the KIT gene in phyllodes tumors, and correlate the findings with pathological parameters and clinical outcome. A total of 272 cases were included in this study. CD117 expression was investigated by immunohistochemistry on tissue microarray sections. Toluidine blue staining was performed to indicate mast cells. Overall, 28 (10%) cases were CD117 positive. CD117 expression was significantly associated with tumor grade (Po0.001), increased stromal hypercellularity (P ¼ 0.003), stromal atypia (P ¼ 0.01), and stromal mitotic activity (Po0.001), permeative microscopic margins (P ¼ 0.002), and presence of hemorrhage (P ¼ 0.001). Expression was also associated with poorer overall survival (P ¼ 0.003). Nineteen cases were further selected for mutation screening through the Affymetrix OncoScan platform. No mutation of the KIT gene was found. Despite a lack of mutations in the KIT gene, CD117 protein expression is associated with unfavorable pathological parameters and poorer prognosis, suggesting an underlying role in the biology of phyllodes tumors.

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Predicting clinical behaviour of breast phyllodes tumours: a nomogram based on histological criteria and surgical margins

Abstract: A predictive nomogram based on three histological criteria and surgical margin status can be used to calculate recurrence-free survival of an individual woman diagnosed with PT. This can be applied for patient counselling and clinical management.

Cited by 253 publications

References 44 publications

A Rare Case of Recurrent Malignant Phyllodes Tumor in Young Female

A Rare Case of Recurrent Malignant Phyllodes Tumor in Young Female

Has color Doppler a role in the evaluation of mammary lesions?

CD117 expression in breast phyllodes tumors correlates with adverse pathologic parameters and reduced survival

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