Predicted effect-site concentration of propofol and sufentanil for gynecological laparoscopic surgery

Sm, Jung; Yang, Chun Woo; Jy, Oh; Ck, Cho; Ps, Kang; Ys, Lim; Sj, Jeong; Hu, Kwon

doi:10.1111/j.1399-6576.2010.02327.x

Cited by 6 publications

(3 citation statements)

References 29 publications

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“…In our study, we calculated the Ce of propofol and delivered propofol with the TCI machine. Schuttler and Kloos (1988) reported a Ce ROC of 1.59 μg ml −1 after 131 min of TCI propofol infusion, and Jung and Yang (2011) reported a Ce ROC of 1.4 μg ml −1 and Ce LOC of 3.4 μg ml −1 with the Schnider model [ 27 – 28 ]. The values in these reports are all higher than those in our study.…”

Section: Discussionmentioning

confidence: 99%

Confounding Factors to Predict the Awakening Effect-Site Concentration of Propofol in Target-Controlled Infusion Based on Propofol and Fentanyl Anesthesia

Chan

Lee

et al. 2015

PLoS ONE

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We conducted a large retrospective study to investigate the confounding factors that predict Ce ROC under propofol-based TIVA with TCI. We recorded sex, age, height, weight, Ce LOC, Ce ROC, total propofol and fentanyl consumption dose, and anesthetic time. Simple linear regression models were used to identify potential predictors of Ce ROC, and multiple linear regression models were used to identify the confounding predictors of Ce ROC. We found that Ce ROC correlated with age, sex, Ce LOC, and both total fentanyl and propofol consumption dose. The prediction formula was: Ce ROC = 0.87 - 0.06 × age + 0.18 × Ce LOC + 0.04 (if fentanyl consumption > 150 μg; if not, ignore this value) + 0.07 × (1 or 2, according to the total propofol consumption dose, 1 for a propofol amount 1000-2000 mg and 2 for a propofol amount > 2000 mg). We simplified the formula further as Ce ROC = 0.87 - 0.06 × age + 0.18 × Ce LOC. In conclusion, Ce ROC can be predicted under TCI with propofol- and fentanyl-based TIVA. The confounding factors that predicted propofol Ce ROC are age, sex, Ce LOC, and total consumption dose of propofol and fentanyl.

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Section: Discussionmentioning

confidence: 99%

Confounding Factors to Predict the Awakening Effect-Site Concentration of Propofol in Target-Controlled Infusion Based on Propofol and Fentanyl Anesthesia

Chan

Lee

et al. 2015

PLoS ONE

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“…Significances of distinction were calculated where applicable and are shown as * for p < 0.05, ** for p < 0.01 and ns for not significant. Coloured bars symbolize ranges of clinical concentrations ( A usems et al., ; K apila et al., ; B arash et al., ; Z hao et al., ; J ung et al., ; V ennila et al., ). Concentration‐response curves for the fentanyl‐type opioids are compiled only from data of the higher concentration ranges as predicted by whole‐cell results, for this was an exploratory study.…”

Section: Resultsmentioning

confidence: 99%

Direct effects of morphine but not of fentanyl‐type opioids on human 5‐HT_3A receptors in outside‐out patch‐clamp studies

Schaaf

Lyutenska

Urban

et al. 2014

European Journal of Pain

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“…19 Recently, sufentanil has been proved effective in some laparoscopic surgery studies, but rarely in laparoscopic myomectomy. 15,20,21 Intraoperative sufentanil has been reported has certain advantages for the patients undergoing laparoscopic cholecystectomy, including reducing stress response, improving recovery effect, and decreasing adverse reactions. 21 Hence, we hypothesized that, except for the administration in anesthesia induction, additional intraoperative administration of sufentanil might be a preferable choice for the patients undergoing laparoscopic myomectomy.…”

Section: Introductionmentioning

confidence: 99%

<p>Effects of Additional Intraoperative Administration of Sufentanil on Postoperative Pain, Stress and Inflammatory Responses in Patients Undergoing Laparoscopic Myomectomy: A Double-Blind, Randomized, Placebo-Controlled Trial</p>

Li¹,

Cao²,

Zhao³

et al. 2020

JPR

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Purpose: Although pain after laparoscopic surgery is assumed to be minor, many women still suffer from unexpected postoperative pain. Thus, we aimed to assess whether additional intraoperative administration of sufentanil could help to improve postoperative pain and related agitation, stress, and inflammation response in patients undergoing laparoscopic myomectomy. Patients and Methods: Forty female patients with uterine myoma scheduled for laparoscopic myomectomy under general anesthesia were randomized to receive sufentanil (group T, n=20) or normal saline (group C, n=20) 1h before the end of the surgery. The postoperative pain, agitation, stress, inflammation, and adverse effects were measured. Results: As the primary outcome, the visual analog scale (VAS) pain score was significantly reduced in group T as compared with group C at each measured time point in a postanesthesia care unit (PACU), VAS 5 min (31.5 ± 2.7 vs 40.6 ± 5.6) (P<0.001), VAS 30 min (36.5 ± 4.5 vs 46.0 ± 2.9) (P<0.001), VAS 1h (37.8 ± 4.0 vs 48.6 ± 5.5) (P<0.001). The secondary outcomes, including the sedation agitation scale (SAS) scores, plasma concentrations of epinephrine and norepinephrine, and the levels of plasma interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor-alpha (TNF-α) in group T were remarkably lower than those in group C (P < 0.001). The cough cases in group T also showed a significant reduction in comparison with group C (P < 0.05). In addition, the anesthetic recovery time, including the spontaneous breathing recovery time and extubation time, were not significantly different between the two groups, as were the cases of respiratory depression and postoperative delirium (P > 0.05). Conclusion: For patients undergoing laparoscopic myomectomy, administration of sufentanil 1 h before the end of surgery shows excellent analgesic and sedative effects, alleviated postoperative stress and inflammatory responses, reduced incidence of cough, without prolonging anesthetic recovery time and increasing adverse reactions.

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Predicted effect-site concentration of propofol and sufentanil for gynecological laparoscopic surgery

Cited by 6 publications

References 29 publications

Confounding Factors to Predict the Awakening Effect-Site Concentration of Propofol in Target-Controlled Infusion Based on Propofol and Fentanyl Anesthesia

Confounding Factors to Predict the Awakening Effect-Site Concentration of Propofol in Target-Controlled Infusion Based on Propofol and Fentanyl Anesthesia

Direct effects of morphine but not of fentanyl‐type opioids on human 5‐HT_3A receptors in outside‐out patch‐clamp studies

<p>Effects of Additional Intraoperative Administration of Sufentanil on Postoperative Pain, Stress and Inflammatory Responses in Patients Undergoing Laparoscopic Myomectomy: A Double-Blind, Randomized, Placebo-Controlled Trial</p>

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Predicted effect-site concentration of propofol and sufentanil for gynecological laparoscopic surgery

Cited by 6 publications

References 29 publications

Confounding Factors to Predict the Awakening Effect-Site Concentration of Propofol in Target-Controlled Infusion Based on Propofol and Fentanyl Anesthesia

Confounding Factors to Predict the Awakening Effect-Site Concentration of Propofol in Target-Controlled Infusion Based on Propofol and Fentanyl Anesthesia

Direct effects of morphine but not of fentanyl‐type opioids on human 5‐HT3A receptors in outside‐out patch‐clamp studies

<p>Effects of Additional Intraoperative Administration of Sufentanil on Postoperative Pain, Stress and Inflammatory Responses in Patients Undergoing Laparoscopic Myomectomy: A Double-Blind, Randomized, Placebo-Controlled Trial</p>

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Direct effects of morphine but not of fentanyl‐type opioids on human 5‐HT_3A receptors in outside‐out patch‐clamp studies