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Oral communication is transient but many important decisions, social contracts and fact 'ndings are 'rst canied out in an oral setup, documented in written form and later retrieved. At Carnegie Mellons University s Interactive Systems Laboratories we have been experimenting with the documentation of meetings. T h s paper summarizes part of the progress that we have made in this test bed, speci'cally on the question of automatic transcription using LVCSR, information access using non-keyword based methods, summarization and user interfaces. The system is capable to automatically construct a searchable and browsable audiovisual database of meetings and provide access to these records.

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A series of PGE2, 16,16-dimethyl-PGE2, and PGF2 alpha analogues modified at the carboxyl terminus with tetrazole, amide, acylurea, imide, and sulfonimide functionalities was evaluated for uterine stimulant, bronchodilator, hypotensive, gastric antisecretory, and diarrheal activity. These compounds were prepared by modification of the Corey prostaglandin synthesis utilizing as a key step condensation of known hemiacetals with the ylide derived from the requisite substituted phosphonium salts. Structure--activity relationships suggest that a proton at the C-1 position appears necessary for agonist activity and the acidity of this proton has a relatively greater influence on activity than pendant steric bulk. Noteworthy are the tissue-selective bronchodilator activity of N-acetyl-PGE2-carboxamide and the selectivity for uterine tissue of N-methanesulfonyl-PGE2-carboxamide, 2-decarboxy-2-(tetrazol-5-yl)-16,16-dimethyl-PGE2, N-acetyl-16,16-dimethyl-PGE2-carboxamide, and N-methanesulfonyl-16,16-dimethyl-PGE2-carboxamide.