Prediabetes predicts adverse cardiovascular outcomes after percutaneous coronary intervention: a meta-analysis

Zhao, Yong; Guo, Min; Shi, Gang

doi:10.1042/bsr20193130

Cited by 12 publications

(14 citation statements)

References 44 publications

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“…Out of the 4807 identified articles, 126 full-texts were assessed for eligibility, and finally, 16 articles were included in this umbrella review (Fig. 1) [7][8][9][10][23][24][25][26][27][28][29][30][31][32][33][34]. A detailed list of the excluded articles and the reasons for their exclusion is displayed in ESM Table 3.…”

Section: Resultsmentioning

confidence: 99%

Prediabetes and risk of mortality, diabetes-related complications and comorbidities: umbrella review of meta-analyses of prospective studies

et al. 2021

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Aims/hypothesis The term prediabetes is used for individuals who have impaired glucose metabolism whose glucose or HbA1c levels are not yet high enough to be diagnosed as diabetes. Prediabetes may already be associated with an increased risk of chronic ‘diabetes-related’ complications. This umbrella review aimed to provide a systematic overview of the available evidence from meta-analyses of prospective observational studies on the associations between prediabetes and incident diabetes-related complications in adults and to evaluate their strength and certainty. Methods For this umbrella review, systematic reviews with meta-analyses reporting summary risk estimates for the associations between prediabetes (based on fasting or 2 h postload glucose or on HbA1c) and incidence of diabetes-related complications, comorbidities and mortality risk were included. PubMed, Web of Science, the Cochrane Library and Epistemonikos were searched up to 17 June 2021. Summary risk estimates were recalculated using a random effects model. The certainty of evidence was evaluated by applying the GRADE tool. This study is registered with PROSPERO, CRD42020153227. Results Ninety-five meta-analyses from 16 publications were identified. In the general population, prediabetes was associated with a 6–101% increased risk for all-cause mortality and the incidence of cardiovascular outcomes, CHD, stroke, heart failure, atrial fibrillation and chronic kidney disease, as well as total cancer, total liver cancer, hepatocellular carcinoma, breast cancer and all-cause dementia with moderate certainty of evidence. No associations between prediabetes and incident depressive symptoms and cognitive impairment were observed (with low or very low certainty of evidence). The association with all-cause mortality was stronger for prediabetes defined by impaired glucose tolerance than for prediabetes defined by HbA1c. Conclusions/interpretation Prediabetes was positively associated with risk of all-cause mortality and the incidence of cardiovascular outcomes, CHD, stroke, chronic kidney disease, cancer and dementia. Further high-quality studies, particularly on HbA1c-defined prediabetes and other relevant health outcomes (e. g. neuropathy) are required to support the evidence. Graphical abstract

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Section: Resultsmentioning

confidence: 99%

Prediabetes and risk of mortality, diabetes-related complications and comorbidities: umbrella review of meta-analyses of prospective studies

et al. 2021

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“…Nevertheless, the results of prospective studies can serve as indirect evidence in favor of the adverse effect of prediabetes on the state of both the arterial wall as a whole and the severity of atherosclerotic changes in it [ 31 , 32 , 33 ]. So, in a recent national cohort study in Korea, with a 12-year prospective observation, it was shown that the DM group showed the highest incidence and risk of vascular complications (cardiovascular, renal; and retinal), followed by the IFG group and the lowest risk was in group of normoglycemia [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

“…In a meta-analysis of longitudinal follow-up studies, it was found that compared with patients with normoglycemia, coronary artery disease (CAD) patients with prediabetes on admission have a significantly higher risk of developing major adverse cardiovascular events after percutaneous coronary intervention (PCI). The potential prognostic role of prediabetes in these patients is the same regardless of study design, sample size, CAD subtype, PCI type, diabetes definition or follow-up duration, and even after adjusting for CAD severity [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Cardio-Ankle Vascular Index in the Persons with Pre-Diabetes and Diabetes Mellitus in the Population Sample of the Russian Federation

Sumin

Безденежных

et al. 2021

Diagnostics

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The aim of this study was to evaluate Cardio-Ankle Vascular Index (CAVI) and increased arterial stiffness predictors in patients with carbohydrate metabolism disorders (CMD) in the population sample of Russian Federation. Methods: 1617 patients (age 25–64 years) were enrolled in an observational cross-sectional study Epidemiology of Cardiovascular Diseases and Their Risk Factors in the Regions of the Russian Federation (ESSE-RF). The standard ESSE-RF protocol has been extended to measure the cardio-ankle vascular index (CAVI), a marker of arterial stiffness. Patients were divided into three groups: patients with type 2 diabetes mellitus (n = 272), patients with prediabetes (n = 44), and persons without CMD (n = 1301). Results: Median CAVI was higher in diabetes and prediabetes groups compared with group without CMD (p = 0.009 and p < 0.001, respectively). Elevated CAVI (≥9.0) was detected in 16.8% of diabetes patients, in 15.9% of those with prediabetes, and in 9.0% of those without CMD (p < 0.001). The factors affecting on CAVI did not differ in CVD groups. In logistic regression the visceral obesity, increasing systolic blood pressure (SBP) and decreasing glomerular filtration rate (GFR) were associated with a pathological CAVI in CMD patients, and age, diastolic blood pressure (DBP), and cholesterol in persons without CMD. Conclusions: the CAVI index values in the prediabetes and diabetes patients were higher than in normoglycemic persons in a population sample of the Russian Federation. Since the identified disorders of arterial stiffness in prediabetes are similar to those in diabetes, their identification is important to prevent further cardiovascular complications.

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“…As demonstrated in figure 2, systematic reviews of observational studies have reported associations between different markers of disturbances in the glucose and insulin metabolism with CVD. Glycemic variability (34) was associated with poorer prognosis in coronary artery disease; fasting glucose (35) with higher risk of major cardiovascular adverse events (36)(37)(38) ; fasting insulin (39,40) with coronary artery disease, but there was no significant association between HOMA-IR (41) and stroke. Ultimately, an increase in C-peptide levels was associated with a rise in CVD mortality (42) .…”

Section: Diabetes and Disturbances In The Glucose And Insulin Metabolismmentioning

confidence: 92%

“…Most of the systematic reviews and meta-analyses on this topic were based on observational study designs, and therefore were prone to residual confounding that may affect the associations between diabetes and risk of cardiovascular disease. Furthermore, significant heterogeneity across studies attributable to variability in the measurement of outcomes and adjustment for covariates (34,35,44,45,48,(51)(52)(53) , subgroup comparisons (54), and duration of follow-up (34,55) , misclassification of diabetic cases (36,45,56) , as well as inconsistencies in defining conventional CVD risk factors (51,52) were observed. Publication bias was found in some of the systematic reviews (34,55,56) , and the limited availability of data and/or studies prevented further use of meta-regression analysis (45,51) .…”

Section: Diabetes and Disturbances In The Glucose And Insulin Metabolismmentioning

confidence: 99%

A synthesis of pathways linking diet, metabolic risk and cardiovascular disease: a framework to guide further research and approaches to evidence-based practice

Vale¹,

Buckner²,

Mitrofan³

et al. 2021

Nutr. Res. Rev.

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Cardiovascular disease (CVD) is the most common non-communicable disease occurring globally. Although previous literature have provided useful insights on the important role that diet play in CVD prevention and treatment, understanding the causal role of diets is a difficult task considering inherent and introduced weaknesses of observational (e.g., not properly addressing confounders and mediators) and experimental research designs (e.g., not appropriate or well-designed). In this narrative review, we organised current evidence linking diet, as well as conventional and emerging physiological risk factors with CVD risk, incidence and mortality in a series of diagrams. The diagrams presented can aid causal inference studies as they provide a visual representation of the types of studies underlying the associations between potential risk markers/factors for CVD. This may facilitate the selection of variables to be considered and the creation of analytical models. Evidence depicted in the diagrams was systematically collected from studies included in the British Nutrition Task Force report on Diet and CVD and database searches, including Medline and Embase. Although several markers and disorders linked to conventional and emerging risk factors for CVD were identified, the causal link between many remains unknown. There is a need to address the multifactorial nature of CVD and the complex interplay between conventional and emerging risk factors with natural and built environments, while bringing the life course and the role of additional environmental factors into the spotlight.

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Prediabetes predicts adverse cardiovascular outcomes after percutaneous coronary intervention: a meta-analysis

Cited by 12 publications

References 44 publications

Prediabetes and risk of mortality, diabetes-related complications and comorbidities: umbrella review of meta-analyses of prospective studies

Prediabetes and risk of mortality, diabetes-related complications and comorbidities: umbrella review of meta-analyses of prospective studies

Cardio-Ankle Vascular Index in the Persons with Pre-Diabetes and Diabetes Mellitus in the Population Sample of the Russian Federation

A synthesis of pathways linking diet, metabolic risk and cardiovascular disease: a framework to guide further research and approaches to evidence-based practice

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