2021
DOI: 10.1007/s00125-021-05592-3
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Abstract: Aims/hypothesis The term prediabetes is used for individuals who have impaired glucose metabolism whose glucose or HbA1c levels are not yet high enough to be diagnosed as diabetes. Prediabetes may already be associated with an increased risk of chronic ‘diabetes-related’ complications. This umbrella review aimed to provide a systematic overview of the available evidence from meta-analyses of prospective observational studies on the associations between prediabetes and incident diabetes-related co… Show more

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Cited by 117 publications
(62 citation statements)
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“…Moreover, serum T levels are inversely related to BMI in obese men, and androgen administration increases insulin sensitivity [83,84] . Accordingly, insulin resistance decreases after T replacement in T2DM patients [85,86] . This Trelated effect on insulin sensitivity is probably multifactorial [42] .…”
Section: Discussionmentioning
confidence: 98%
“…Moreover, serum T levels are inversely related to BMI in obese men, and androgen administration increases insulin sensitivity [83,84] . Accordingly, insulin resistance decreases after T replacement in T2DM patients [85,86] . This Trelated effect on insulin sensitivity is probably multifactorial [42] .…”
Section: Discussionmentioning
confidence: 98%
“…Overfeeding and sedentary lifestyles drive the development of a systemic metabolic imbalance and the emergence of obesity and prediabetes that are strongly associated with all-cause dementia, Alzheimer’s disease (AD), and vascular dementia (e.g., [ 216 ]). Obesity is associated with comorbidities such as hypertension, cardiovascular disease, metabolic syndrome, and insulin resistance or type 2 diabetes [ 216 , 217 ], which might modulate the genetic susceptibility to neurodegenerative disorders [ 218 ] and thus constitute a risk factor for cognitive decline [ 219 , 220 ].…”
Section: Discussionmentioning
confidence: 99%
“…Overfeeding and sedentary lifestyles drive the development of a systemic metabolic imbalance and the emergence of obesity and prediabetes that are strongly associated with all-cause dementia, Alzheimer’s disease (AD), and vascular dementia (e.g., [ 216 ]). Obesity is associated with comorbidities such as hypertension, cardiovascular disease, metabolic syndrome, and insulin resistance or type 2 diabetes [ 216 , 217 ], which might modulate the genetic susceptibility to neurodegenerative disorders [ 218 ] and thus constitute a risk factor for cognitive decline [ 219 , 220 ]. The reported cytoprotective actions of taurine contribute to brain health improvements in subjects with obesity and diabetes through various mechanisms that improve neuronal function, such as the modulation of inhibitory neurotransmission and, therefore, the promotion of an excitatory–inhibitory balance, the stimulation of antioxidant systems, and the stabilization of mitochondria and thus of energy production and Ca 2+ homeostasis.…”
Section: Discussionmentioning
confidence: 99%
“…Thus, the mechanisms underlying the T2D in ZDSD rats might be more similar to those in humans, because leptin receptor mutations are rare in humans (Davidson et al., 2014). Zucker Diabetic‐Sprague Dawley rats also show age‐dependent and reproducible progression that bears a qualitative resemblance to prediabetic changes of blood glucose concentration and insulin sensitivity that occur in humans (Choy, de Winter et al., 2016; Han et al., 2020; Peterson et al., 2015); albeit in some cases spanning decades (Bertram & Vos, 2010; Schlesinger et al., 2022). In addition to using the ZDSD rat to study the prediabetic condition, the extended period of development of T2D, as opposed to shorter periods in other models, has led to uncovering the merit of using the ZDSD rat to study longer‐term developmental changes, such as bone turnover and skeletal development (Reinwald et al., 2009).…”
Section: Introductionmentioning
confidence: 99%