Precurarisation in infants and children less than three years of age

Cozanitis, D. A.; Erkola, Olli; Klemola, Ulla-Maija; Mäkelä, Virve

doi:10.1007/bf03007676

Cited by 10 publications

(2 citation statements)

References 12 publications

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“…Other common side-effects of suxamethonium (jaw stiffness, arrhythmias, hyperkalaemia, a rise in in- I I I I I I I I I I I I I I I 1 1 2 5 10 20 1 2 3 6 1 2 3 6 8 1 0 1 6 -Days -Months--Yearstraocdar pressure and metabolic changes) may hold a clue, but they have not been systematically evaluated in infants. Given the fact that fasciculations are absent in infants, or are present only as uncoordinated muscle movements (Cozanitis et al 1987), it is unreasonable to make any effort to abolish this by the prior administration of small doses of non-depolarizing relaxants. Furthermore, should the infant be unusually sensitive to the non-depolarizing relaxant, the possibility exists that a fast paralysis will unexpectedly occur.…”

Section: Suxamethoniummentioning

confidence: 99%

Myoneural blocking agents in infants: a review

Goudsouzian

Shorten

1992

Pediatric Anesthesia

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Section: Suxamethoniummentioning

confidence: 99%

Myoneural blocking agents in infants: a review

Goudsouzian

Shorten

1992

Pediatric Anesthesia

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“…Fasciculations tend to occur less frequently and to be less intense in children than in adolescents. In children of 1-3 years of age they have been described as gross muscle movements (Cozantis et al 1987). A mild concomitant rise in intragastric pressure may be observed but is of minimal clinical significance (Salem, Wong & Lin 1972).…”

Section: Suxamethoniummentioning

confidence: 99%

Neuromuscular blocking agents in children

Goudsouzian¹

1991

Pediatric Anesthesia

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This article will review the pharmacology of muscle relaxants in children. The neuromuscular pharmacology of the very young (infants less than one year) will be discussed in the next issue of the Journal. In this review the neuromuscular blocking drugs will be discussed in the order of their duration of action. Swamethonium and the recently developed shortacting mivacurium will be considered, followed by the two intermediate-acting agents vecuronium and atracurium (see Figure 1). The last group to be discussed will be the long-acting compounds (pancuronium, tubocurarine, metocurine, alcuronium, gallamine, doxacurium and pipecuronium) (see Figure 2 and Table 1). SuxamethoniumSwamethonium (succinyldicholine) is still the shortest acting neuromuscular blocking agent and the only depolarizing compound regularly used in children. Determinations of effective doses have shown that the ED95 in children less than 10 years of age is 0.42-0.45 mgkg-'; in older children (more than 11 years) the ED95 is 0.27 mg-kg-' a value comparable to that in adults (ED95 0.29 mgkg-') (Meakin et al.

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Theoretische und praktische Erwägungen der Relaxation bei Neugeborenen und Säuglingen

Braun¹

1989

Anästhesie Bei Früh- Und Neugeborenen

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Precurarisation in infants and children less than three years of age

Cited by 10 publications

References 12 publications

Myoneural blocking agents in infants: a review

Myoneural blocking agents in infants: a review

Neuromuscular blocking agents in children

Theoretische und praktische Erwägungen der Relaxation bei Neugeborenen und Säuglingen

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