Myoneural blocking agents in infants: a review

Goudsouzian, Nishan G.; Shorten, George

doi:10.1111/j.1460-9592.1992.tb00474.x

Cited by 7 publications

(3 citation statements)

References 107 publications

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“…The present study during balanced anaesthesia showed that children require significantly more rocuronium to achieve the same level of neuromuscular block than infants or adults. Similar results regarding age-dependent potency have been obtained in several other studies of nondepolarizing muscle relaxants (13). Different dose requirements of rocuronium found in infants, children and adults may be due to differences in body composition during the growth period.…”

Section: Discussionsupporting

confidence: 83%

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Rocuronium in infants, children and adults during balanced anaesthesia

Taivainen

Meretoja

Erkola

et al. 1996

Pediatric Anesthesia

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We studied 20 infants, 20 children and 20 adults during balanced anaesthesia to compare the neuromuscular blocking effects of rocuronium in these age groups. Neuromuscular function was recorded by adductor pollicis emg and a cumulative log-probit dose-response curve of rocuronium was established. Thereafter, full spontaneous recovery of the neuromuscular function was recorded. Onset time of the first dose of rocuronium was shorter in children than in infants or adults. The potency of rocuronium was greatest in infants and least in children; the ED50 doses (mean +/- SD) being 149 +/- 36 micrograms.kg-1 in infants, 205 +/- 52 micrograms.kg-1 in children and 169 +/- 47 micrograms.kg-1 in adults (P < 0.05 between infants and children) and the ED95 doses being 251 +/- 73 micrograms.kg-1, 409 +/- 71 micrograms.kg-1 and 350 +/- 77 micrograms.kg-1, respectively (P < 0.05 between all groups). The emg recovery following an average 94.5 +/- 4.8% neuromuscular blockade established by rocuronium was roughly similar in all study groups. Thus, one ED95 dose of rocuronium, unlike vecuronium, acts as an intermediate-acting agent in all age groups.

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Section: Discussionsupporting

confidence: 83%

“…In the case of vecuronium, it is possible that the early distribution is slower in infants than in children and results in slower decrease of plasma concentration and thus slower neuromuscular recovery in infants than in children (20). Neither atracurium nor mivacurium have this age related difference in rate of recovery (13).…”

Section: Discussionmentioning

confidence: 98%

Rocuronium in infants, children and adults during balanced anaesthesia

Taivainen

Meretoja

Erkola

et al. 1996

Pediatric Anesthesia

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“…1984;Goudsouzian 1986;Meakin et al 1988). The same is true for pancuronium and tubocurarine (Goudsouzian et al 1975;Meretoja & Luosto 1990;Goudsouzian & Shorten 1992). In the case of pipecuronium, the rate of spontaneous recovery of the neuromuscular block is also similar in infants and in children, even though infants show a shorter duration of neuromuscular block than children (Pittet ei aZ.…”

Section: Discussionmentioning

confidence: 92%

Duration of action of an equipotent dose of vecuronium in infants and in children

Taivainen

Praefort

Meretoja

1993

Pediatric Anesthesia

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Summa yDuring general anaesthesia without any volatile anaesthetic agents, ten infants and ten children received incremental doses of vecuronium to achieve a 95% neuromuscular block. Thereafter, the thenar electromyographic response was allowed to recover spontaneousIy.Total dose of vecuronium to establish a 95.0 t 0.5% (mean t SEM) neuromuscular block was 66% greater for children than for infants (73 5 4 us. 44 k 4 pg-kg-', P < 0.0001). However, recovery index and time to complete recovery of the neuromuscular function were 88 and 89% longer, respectively, in infants than in children (P < 0.0001). These results of the effect of an equipotent dose of vecuronium in infants and in children confirm that vecuronium is a long acting neuromuscular blocking agent in infants.

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Pediatric Anesthesia Techniques

Cook-Sather¹,

Schreiner²

2002

Pediatric Oculoplastic Surgery

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Myoneural blocking agents in infants: a review

Cited by 7 publications

References 107 publications

Rocuronium in infants, children and adults during balanced anaesthesia

Rocuronium in infants, children and adults during balanced anaesthesia

Duration of action of an equipotent dose of vecuronium in infants and in children

Pediatric Anesthesia Techniques

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