Precontact 50-kHz vocalizations in male rats during acquisition of sexual experience.

Bialy, Michał; Rydz, Marek; Kaczmarek, Leszek

doi:10.1037//0735-7044.114.5.983

Cited by 46 publications

References 56 publications

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50‐kHz ultrasonic vocalizations do not signal social anhedonia in transgenic DISC1 rats

et al. 2023

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Patients diagnosed with neuropsychiatric disorders, such as autism and schizophrenia, suffer from disorganized speech. The disrupted-in-schizophrenia 1 (DISC1) protein pathway is considered a risk factor for the development of several psychiatric disorders and plays an important role in the dysregulation of dopamine (DA), which in turn plays an important role in the regulation of ultrasonic vocalizations (USVs) in rats. Moreover, the DISC1 protein pathway has been identified as a cause of social anhedonia, that is, a decrease in the drive for social interactions. USVs transmit specific affective information to other rats, with 50-kHz calls indicating a positive affective state in rats. Dysregulation of the dopaminergic system impacts the qualitative and quantitative features of USVs, such as duration, peak frequency, and the call rate. In this study, we thus used a well-established transgenic DISC1 (tgDISC1) rat line to investigate whether the neural (decreased DA levels in the dorsal striatum, amygdala, and hippocampus (HPC)) and behavioral (social anhedonia) features of tgDISC1 rats could be manifested through the modulation of their 50-kHz USVs. Analyses of three features (call rate, duration, and peak frequency) of all 50-kHz revealed no significant differences between groups, suggesting decreased DA levels in the dorsal striatum and amygdala, and HPC may affect social interaction but leave 50-kHz USV production intact.

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50‐kHz ultrasonic vocalizations do not signal social anhedonia in transgenic DISC1 rats

et al. 2023

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Acoustic Properties and Biological Significance of Ultrasonic Vocalizations in Rodents: Emotional Expressions

Okabe

Kanno

2023

Acoustic Communication in Animals

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Ultrasonic vocalization in rats self-administering heroin and cocaine in different settings: evidence of substance-specific interactions between drug and setting

et al. 2016

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RationaleClinical and preclinical evidence indicates that the setting of drug use affects drug reward in a substance-specific manner. Heroin and cocaine co-abusers, for example, indicated distinct settings for the two drugs: heroin being used preferentially at home and cocaine preferentially outside the home. Similar results were obtained in rats that were given the opportunity to self-administer intravenously both heroin and cocaine.ObjectivesThe goal of the present study was to investigate the possibility that the positive affective state induced by cocaine is enhanced when the drug is taken at home relative to a non-home environment, and vice versa for heroin.MethodsTo test this hypothesis, we trained male rats to self-administer both heroin and cocaine on alternate days and simultaneously recorded the emission of ultrasonic vocalizations (USVs), as it has been reported that rats emit 50-kHz USVs when exposed to rewarding stimuli, suggesting that these USVs reflect positive affective states.ResultsWe found that Non-Resident rats emitted more 50-kHz USVs when they self-administered cocaine than when self-administered heroin whereas Resident rats emitted more 50-kHz USVs when self-administering heroin than when self-administering cocaine. Differences in USVs in Non-Resident rats were more pronounced during the first self-administration (SA) session, when the SA chambers were completely novel to them. In contrast, the differences in USVs in Resident rats were more pronounced during the last SA sessions.ConclusionThese findings indicate that the setting of drug taking exerts a substance-specific influence on the ability of drugs to induce positive affective states.

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Precontact 50-kHz vocalizations in male rats during acquisition of sexual experience.

Cited by 46 publications

References 56 publications

50‐kHz ultrasonic vocalizations do not signal social anhedonia in transgenic DISC1 rats

50‐kHz ultrasonic vocalizations do not signal social anhedonia in transgenic DISC1 rats

Acoustic Properties and Biological Significance of Ultrasonic Vocalizations in Rodents: Emotional Expressions

Ultrasonic vocalization in rats self-administering heroin and cocaine in different settings: evidence of substance-specific interactions between drug and setting

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